NITROGEN BALANCE.—_Chittenden._

Nitrogen Output.

Taken in. Nitrogen in Urine. Weight of Fæces[33] (dry).

March 20 6.989 grams. 5.91 grams. 3.6 grams.

21 6.621 5.52 0.0

22 6.082 5.94 12.0

23 6.793 5.61 18.5

24 5.057 4.31 23.0

25 6.966 5.39 16.9

------ ------ ------

74.0 grams contain 6.42% N.

38.508 32.68 + 4.75 grams nitrogen.

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38.508 grams nitrogen. 37.43 grams nitrogen.

Nitrogen balance for six days = +1.078 grams.

Nitrogen balance per day = +0.179 gram.

Average Intake.

Calories per day 1613.

Nitrogen per day 6.40 grams.

Examination of the results shown in the foregoing balance makes it quite

clear that the body was essentially in nitrogenous equilibrium. Indeed,

there was a slight plus balance, showing that even with the small intake

of proteid food the body was storing up nitrogen at the rate of 0.16 gram

per day. The average daily intake of nitrogen for the six days’ period

was 6.40 grams, equal to 40.0 grams of proteid or albuminous food. The

average daily output of nitrogen through the urine and fæces was 6.24

grams. The average daily output of nitrogen through the urine for the six

days’ period was 5.44 grams, corresponding to the metabolism of 34 grams

of proteid material. When these figures are contrasted with the usually

accepted standards of proteid requirement for the healthy man, they are

certainly somewhat impressive, especially when it is remembered that

the body at that date had been in essentially this same condition for

at least six months, and probably for an entire year. The Voit standard

of 118 grams of proteid, with an equivalent of at least 18 grams of

nitrogen and calling for the metabolism of 105 grams of proteid, or 16.5

grams of nitrogen per day, makes clear how great a physiological economy

had been accomplished. In other words, the consumption of proteid food

was reduced to at least one-third the daily amount generally considered

as representing the average requirement of the healthy man, and this

with maintenance of body-weight at practically a constant point for the

preceding ten months, and, so far as the writer can observe, with no loss

of vigor, capacity for mental and physical work, or endurance. Indeed,

the writer is disposed to maintain that he has done more work and led

a more active life in every way during the period of this experiment,

and with greater comfort and less fatigue than usual. His health has

certainly been of the best during this period.

In this connection it may be well to call attention to the completeness

of the utilization of the daily food in this six days’ experiment, as

shown by the small amount of refuse discharged per rectum, indicating

as it does the high efficiency of the digestive processes and of the

processes of absorption. The refuse matter for the entire period of six

days amounted when dry to only 74 grams, and when it is remembered how

large a proportion of this refuse must of necessity be composed of the

cast-off secretions from the body, it will be seen how thorough must have

been the utilization of the food by the system. The loss of nitrogen

to the body per day through the fæces amounted to only 0.79 gram, and

this on a mixed diet containing considerable matter not especially

concentrated, and on some days with noticeable amounts of food, such as

salads, not particularly digestible.

Finally, emphasis should be laid upon the fact that this economy of

proteid food, this establishment of nitrogen equilibrium on a low

proteid intake, was accomplished without increase in the daily intake of

non-nitrogenous foods. In fact, the amount of fats and carbohydrates was

likewise greatly reduced, far below the minimal standard of 3000 calories

as representing the potential energy or fuel value of the daily diet.

Indeed, during the balance period of six days just described the average

fuel value of the food per day was only a little over 1600 calories.

As the experiment continued and the record for the months of April and

May was obtained, it became evident from the nitrogen results that the

rate of proteid katabolism was being still more reduced. A second balance

experiment was therefore tried with a view to seeing if the body was

still in nitrogen equilibrium, and also to ascertain whether the fuel

value of the food still showed the same low calorific power. For a period

of five days, June 23 to 27, the intake of food and the entire output

were carefully compared, with the results shown in the accompanying

tables.

_Thursday, June 23, 1904._

Breakfast.—Coffee 123 grams, cream 50 grams, sugar 11 grams.

Lunch.—Omelette 50 grams, French fried potatoes 70 grams, bacon 10 grams,

wheat gems 43 grams, butter 9 grams, strawberries 125 grams, sugar 20

grams, cream cake 59 grams.

Dinner.—Beefsteak 34 grams, peas 60 grams, creamed potato 97 grams, bread

26 grams, butter 17 grams, lettuce-orange salad 153 grams, crackers 43

grams, cream cheese 15 grams, coffee 53 grams, sugar 12 grams.

Food. Grams. Per cent Nitrogen. Total Nitrogen.

Coffee 123 + 53 = 176 × 0.045 = 0.079 gram.

Cream 50 × 0.35 = 0.175

Sugar 11 + 20 + 12 = 43 × 0.00 = 0.000

Omelette 50 × 1.32 = 0.660

French fried potatoes 70 × 0.37 = 0.259

Bacon 10 × 3.43 = 0.343

Wheat gems 43 × 1.49 = 0.641

Butter 9 + 17 = 26 × 0.13 = 0.034

Strawberries 125 × 0.11 = 0.138

Cream cake 59 × 0.98 = 0.578

Beefsteak 34 × 4.14 = 1.408

Peas 60 × 0.97 = 0.582

Creamed potato 97 × 0.34 = 0.330

Bread 26 × 1.23 = 0.320

Lettuce-orange salad 153 × 0.15 = 0.230

Crackers 43 × 1.40 = 0.602

Cream cheese 15 × 1.62 = 0.243

------

Total nitrogen in food 6.622 grams.

Total nitrogen in urine 5.260

Fuel value of the food 1863 calories.

_Friday, June 24, 1904._

Breakfast.—Coffee 96 grams, sugar 8 grams, milk 32 grams.

Lunch.—Creamed codfish 89 grams, baked potato 95 grams, butter 10 grams,

hominy gems 58 grams, strawberries 86 grams, sugar 26 grams, ginger snaps

47 grams.

Dinner.—Cold tongue 14 grams, fried potato 48 grams, peas 60 grams, wheat

gems 30 grams, butter 11 grams, lettuce-orange salad with mayonnaise

dressing 155 grams, crackers 22 grams, cream cheese 14 grams, ginger

snaps 22 grams, coffee 58 grams, sugar 10 grams.

Food. Grams. Per cent Nitrogen. Total Nitrogen.

Coffee 123 + 53 = 176 × 0.045 = 0.079 gram.

Sugar 8 + 26 + 10 = 44 × 0.00 = 0.000

Milk 32 × 0.51 = 0.163

Creamed codfish 89 × 1.78 = 1.584

Baked potato 95 × 0.29 = 0.276

Butter 10 + 11 = 21 × 0.13 = 0.027

Hominy gems 58 × 1.20 = 0.696

Strawberries 86 × 0.11 = 0.095

Ginger snaps 47 + 22 = 69 × 1.15 = 0.794

Cold tongue 14 × 4.87 = 0.682

Fried potato 48 × 0.37 = 0.178

Peas 60 × 0.94 = 0.564

Wheat gems 30 × 1.45 = 0.435

Lettuce-orange salad, etc. 155 × 0.15 = 0.233

Crackers 22 × 1.40 = 0.308

Cream cheese 14 × 1.62 = 0.227

------

Total nitrogen in food 6.331 grams.

Total nitrogen in urine 5.300

Fuel value of the food 1506 calories.

_Saturday, June 25, 1904._

Breakfast.—Coffee 101 grams, milk 36 grams, sugar 13 grams.

Lunch.—Omelette 50 grams, bacon 9 grams, French fried potato 23 grams,

biscuit 29 grams, butter 8 grams, cream cheese 17 grams, iced tea 150

grams, sugar 15 grams, ginger snaps 42 grams.

Dinner.—Wheat popovers 57 grams, butter 10 grams, lettuce-orange salad

with mayonnaise dressing 147 grams, cream cheese 21 grams, crackers 22

grams, cottage pudding 82 grams, coffee 48 grams, sugar 11 grams.

Food. Grams. Per cent Nitrogen. Total Nitrogen.

Coffee 1201 + 48 = 149 × 0.045 = 0.067 gram.

Milk 36 × 0.46 = 0.166

Sugar 13 + 15 + 11 = 39 × 0.00 = 0.000

Omelette 50 × 1.42 = 0.710

Bacon 9 × 2.66 = 0.239

French fried potato 23 × 0.57 = 0.131

Biscuit 29 × 1.35 = 0.392

Butter 8 + 10 = 18 × 0.13 = 0.023

Iced tea 150 × 0.018 = 0.027

Ginger snaps 42 × 1.15 = 0.483

Cream cheese 17 + 21 = 38 × 1.62 = 0.616

Wheat popovers 57 × 1.64 = 0.935

Lettuce-orange salad 147 × 0.15 = 0.221

Crackers 22 × 1.40 = 0.308

Cottage pudding 82 × 0.76 = 0.623

------

Total nitrogen in food 4.941 grams.

Total nitrogen in urine 4.430

Fuel value of the food 1392 calories.

_Sunday, June 26, 1904._

Breakfast.—Coffee 122 grams, cream 31 grams, sugar 8 grams.

Dinner.—Roast lamb 50 grams, baked potato 52 grams, peas 64 grams,

biscuit 32 grams, butter 12 grams, lettuce salad 43 grams, cream cheese

21 grams, toasted crackers 23 grams, blanc mange 164 grams.

Supper.—Iced tea 225 grams, sugar 29 grams, lettuce sandwich 51 grams,

strawberries 130 grams, sugar 22 grams, cream 40 grams, sponge cake 31

grams.

Food. Grams. Per cent Nitrogen. Total Nitrogen.

Coffee 122 × 0.045 = 0.055 gram.

Cream 31 + 40 = 71 × 0.32 = 0.227

Sugar 8 + 26 + 10 = 44 × 0.00 = 0.000

Roast lamb 50 × 4.28 = 2.140

Baked potato 52 × 0.29 = 0.151

Peas 64 × 1.04 = 0.666

Biscuit 32 × 1.35 = 0.432

Butter 12 × 0.13 = 0.016

Lettuce salad 43 × 0.23 = 0.099

Cream cheese 21 × 1.62 = 0.340

Toasted crackers 23 × 1.36 = 0.313

Blanc mange 164 × 0.35 = 0.574

Iced tea 225 × 0.018 = 0.041

Lettuce sandwich 51 × 0.85 = 0.434

Strawberries 130 × 0.11 = 0.143

Sponge cake 31 × 0.94 = 0.291

------

Total nitrogen in food 5.922 grams.

Total nitrogen in urine 4.660

Fuel value of the food 1533 calories.

_Monday, June 27, 1904._

Breakfast.—Coffee 112 grams, cream 22 grams, sugar 10 grams.

Lunch.—Roast lamb 9 grams, baked potato 90 grams, wheat gems 47 grams,

butter 12 grams, sugar 25 grams, iced tea 250 grams, vanilla éclair 47

grams.

Dinner.—Lamb chop 32 grams, asparagus 49 grams, butter 17 grams, creamed

potato 107 grams, bread 35 grams, lettuce-orange salad with mayonnaise

dressing 150 grams, cream cheese 12 grams, crackers 21 grams, coffee 63

grams, sugar 9 grams.

Food. Grams. Per cent Nitrogen. Total Nitrogen.

Coffee 123 + 53 = 176 × 0.045 = 0.079 gram.

Cream 22 × 0.32 = 0.070

Sugar 10 + 25 + 9 = 44 × 0.00 = 0.000

Iced tea 250 × 0.018 = 0.045

Baked potato 90 × 0.25 = 0.225

Wheat gems 47 × 1.65 = 0.776

Butter 12 + 17 = 29 × 0.13 = 0.038

Roast lamb 9 × 4.28 = 0.385

Vanilla éclair 47 × 0.85 = 0.400

Lamb chops 32 × 4.57 = 1.462

Asparagus 49 × 0.59 = 0.289

Creamed potato 107 × 0.40 = 0.428

Bread 35 × 1.33 = 0.466

Lettuce-orange salad, etc. 150 × 0.23 = 0.345

Cream cheese 12 × 1.62 = 0.194

Crackers 21 × 1.35 = 0.284

------

Total nitrogen in food 5.486 grams.

Total nitrogen in urine 4.980

Fuel value of the food 1454 calories.

Physiological economy in nutrition, with special reference to the minimal proteid requirement of the healthy man an experimental study · 第 83 / 237 题