43. Partial differential coefficients of the second and higher orders

can be formed in the same way as those of the first order. For

example, when there are two variables x, y, the first partial

derivatives ð[f]/ðx and ð[f]/ðy are functions of x and y, which we may

seek to differentiate partially with respect to x or y. The most

important theorem in relation to partial differential coefficients of

orders higher than the first is the theorem that the values of such

coefficients do not depend upon the order in which the

differentiations are performed. For example, we have the equation

ð /ð[f]\ ð /ð[f]\

-- ( ---- ) = -- ( ---- ) (i.)

ðx \ ðy / ðy \ ðx /

This theorem is not true without limitation. The conditions for its

validity have been investigated very completely by H. A. Schwarz (see

his _Ges. math. Abhandlungen_, Bd. 2, Berlin, 1890, p. 275). It is a

sufficient, though not a necessary, condition that all the

differential coefficients concerned should be continuous functions of

x, y. In consequence of the relation (i.) the differential

coefficients expressed in the two members of this relation are written

ð²f ð²f

---- or ----.

ðxðy ðyðx

The differential coefficient

ð^_n [f]

--------------,

ðx^p ðy^q ðz^r

in which p + g + r = n, is formed by differentiating p times with

respect to x, q times with respect to y, r times with respect to z,

the differentiations being performed in any order. Abbreviated

notations are sometimes used in such forms as

(p, q, r)

[f] or [f] .

x^p y^q z^r x, y, z

_Differentials_ of higher orders are introduced by the defining

equation

/ ð ð \ n

d^n [f] = ( dx -- + dy -- ) [f]

\ ðx ðy/

ð^n [f] ð^n [f]

= (dx)^n ------- + n(dx)^(n-1) dy ----------- + ...

ðx^n ðx^(n-1) ðy

in which the expression (dx·ð/ðx + dy·ð/ðy)^n is developed by the

binomial theorem in the same way as if dx·ð/ðx and dy·ð/ðy were

numbers, and (ð/ðx)^r·(ð/ðy)^(n-r) [f] is replaced by ð^n [f]/[ðx^r

ðy^(n-r)]. When there are more than two variables the multinomial

theorem must be used instead of the binomial theorem.

The problem of forming the second and higher differential coefficients

of _implicit functions_ can be solved at once by means of partial

differential coefficients, for example, if [f](x, y) = 0 is the

equation defining y as a function of x, we have

_ _

d²y /ð[f]\ -3 | /ð[f]\² ð²[f] ð[f] ð[f] ð²[f] /ð[f]\² ð²[f] |

--- = ( ---- ) | ( ---- ) ----- - 2 ---- · ---- · ----- + ( ---- ) ----- |.

dx² \ ðy / |_ \ ðy / ðx² ðx ðy ðxðy \ ðx / ðy² _|

The differential expression Xdx + Ydy, in which both X and Y are

functions of the two variables x and y, is a _total differential_ if

there exists a function [f] of x and y which is such that

ð[f]/ðx = X, ð[f]/ðy = Y.

When this is the case we have the relation

ðY/ðx = ðX/ðy. (ii.)

Conversely, when this equation is satisfied there exists a function

[f] which is such that

d[f] = Xdx + Ydy.

The expression Xdx + Ydy in which X and Y are connected by the

relation (ii.) is often described as a "perfect differential." The

theory of the perfect differential can be extended to functions of n

variables, and in this case there are ½n(n - 1) such relations as

(ii.).

In the case of a function of two variables x, y an abbreviated

notation is often adopted for differential coefficients. The function

being denoted by z, we write

ðz ðz ð²z ð²z ð²z

p, q, r, s, t for --, --, ---, ----, ---.

ðx ðy ðx² ðxðy ðy²

Partial differential coefficients of the second order are important in

geometry as expressing the curvature of surfaces. When a surface is

given by an equation of the form z = [f](x, y), the lines of curvature

are determined by the equation

{(l + q²)s - pqt} (dy)² + {(1 + q²)r - (1 + p²)t} dx dy

- {(1 + p²)s - pqr} (dx)² = 0,

and the principal radii of curvature are the values of R which satisfy

the equation

R²(rt - s²) - R{(1 + q²)r - 2pqs + (1 + p²)t} [root](1 + p² + q²)

+ (1 + p² + q²)² = 0.

Change of variables.

44. The problem of change of variables was first considered by Brook

Taylor in his _Methodus incrementorum_. In the case considered by

Taylor y is expressed as a function of z, and z as a function of x,

and it is desired to express the differential coefficients of y with

respect to x without eliminating z. The result can be obtained at once

by the rules for differentiating a product and a function of a

function. We have

dy dy dz

-- = -- · --,

dx dz dx

d²y dy d²z d²y /dz\²

--- = -- · --- + --- · ( -- ),

dx² dz dx² dz² \dx/

d³y dy d³z, d²y dz d²z, d³y /dz\³

--- = -- · --- + 3 --- · -- · --- + --- · ( -- ) ,

dx³ dz dx³ dz² dx dx² dz³ \dx/

. . . . . . .

The introduction of partial differential coefficients enables us to

deal with more general cases of change of variables than that

considered above. If u, v are new variables, and x, y are connected

with them by equations of the type

x = [f]1(u, v), y = [f]2(u, v), (i.)

while y is either an explicit or an implicit function of x, we have

the problem of expressing the differential coefficients of various

orders of y with respect to x in terms of the differential

coefficients of v with respect to u. We have

dy /ð[f]2 ð[f]2 dv \ / /ð[f]1 ð[f]1 dv \

-- = ( ----- + ----- -- ) / ( ----- + ----- -- )

dx \ ðu ðv du / / \ ðu ðv du /

by the rule of the total differential. In the same way, by means of

differentials of higher orders, we may express d²y/dx², and so on.

Equations such as (i.) may be interpreted as effecting a

_transformation_ by which a point (u, v) is made to correspond to a

point (x, y). The whole theory of transformations, and of functions,

or differential expressions, which remain invariant under groups of

transformations, has been studied exhaustively by Sophus Lie (see, in

particular, his _Theorie der Transformationsgruppen_, Leipzig,

1888-1893). (See also DIFFERENTIAL EQUATIONS and GROUPS).

A more general problem of change of variables is presented when it is

desired to express the partial differential coefficients of a function

V with respect to x, y, ... in terms of those with respect to u, v,

..., where u, v, ... are connected with x, y, ... by any functional

relations. When there are two variables x, y, and u, v are given

functions of x, y, we have

ðV ðV ðu ðV ðv

-- = -- -- + -- --,

ðx ðu ðx ðv ðx

ðV ðV ðu ðV ðv

-- = -- -- + -- --,

ðy ðu ðy ðv ðy

and the differential coefficients of higher orders are to be formed by

repeated applications of the rule for differentiating a product and

the rules of the type

ð ðu ð ðv ð

-- = -- -- + -- --.

ðx ðx ðu ðx ðx

When x, y are given functions of u, v, ... we have, instead of the

above, such equations as

ðV ðV ðx ðV ðy

-- = -- -- + -- --;

ðu ðx ðu ðy ðu

and ðV/ðx, ðV/ðy can be found by solving these equations, provided the

Jacobian ð(x, y) / ð(u, v) is not zero. The generalization of this

method for the case of more than two variables need not detain us.

In cases like that here considered it is sometimes more convenient not

to regard the equations connecting x, y with u, v as effecting a point

transformation, but to consider the loci u = const., v = const. as two

"families" of curves. Then in any region of the plane of (x, y) in

which the Jacobian ð(x, y) / d(u, v) does not vanish or become

infinite, any point (x, y) is uniquely determined by the values of u

and v which belong to the curves of the two families that pass through

the point. Such variables as u, v are then described as "curvilinear

coordinates" of the point. This method is applicable to any number of

variables. When the loci u = const., ... intersect each other at right

angles, the variables are "orthogonal" curvilinear coordinates.

Three-dimensional systems of such coordinates have important

applications in mathematical physics. Reference may be made to G.

Lamé, _Leçons sur les coordonnées curvilignes_ (Paris, 1859), and to

G. Darboux, _Leçons sur les coordonnées curvilignes et systèmes

orthogonaux_ (Paris, 1898).

When such a coordinate as u is connected with x and y by a functional

relation of the form [f](x, y, u) = 0 the curves u = const. are a

family of curves, and this family may be such that no two curves of

the family have a common point. When this is not the case the points

in which a curve [f](x, y, u) = 0 is intersected by a curve [f](x, y,

u + [Delta]u) = 0 tend to limiting positions as [Delta]u is diminished

indefinitely. The locus of these limiting positions is the "envelope"

of the family, and in general it touches all the curves of the family.

It is easy to see that, if u, v are the parameters of two families of

curves which have envelopes, the Jacobian ð(x, y) / ð(u, v) vanishes

at all points on these envelopes. It is easy to see also that at any

point where the reciprocal Jacobian ð(u, v) / ð(x, y) vanishes, a

curve of the family u touches a curve of the family v.

If three variables x, y, z are connected by a functional relation

[f](x, y, z) = 0, one of them, z say, may be regarded as an _implicit

function_ of the other two, and the partial differential coefficients

of z with respect to x and y can be formed by the rule of the total

differential. We have

ðz ð[f] / ð[f] ðz ð[f] / ð[f]

-- = - ---- / ----, -- = - ---- / ----;

ðx ðx / ðz ðy ðy / ðz

and there is no difficulty in proceeding to express the higher

differential coefficients. There arises the problem of expressing the

partial differential coefficients of x with respect to y and z in

terms of those of z with respect to x and y. The problem is known as

that of "changing the dependent variable." It is solved by applying

the rule of the total differential. Similar considerations are

applicable to all cases in which n variables are connected by fewer

than n equations.

Extension of Taylor's theorem.

45. Taylor's theorem can be extended to functions of several

variables. In the case of two variables the general formula, with a

remainder after n terms, can be written most simply in the form

[f](a + h, b + k) = [f](a, b) + d[f](a, b) + (1/2!) d²[f](a, b) + ...

1 1

+ -------- d^(n-1) [f](a, b) + -- d^n [f](a+[Theta]h, b + [theta]k),

(n - 1)! n!

in which

_ _

| / ð ð \r |

d^r [f](a, b) = | ( h -- + k -- ) [f](x, y) | ,

|_ \ ðx ðy / _| x=a, y=b

and

d^n [f](a + [Theta]h, b + [Theta]k) =

_ _

| / ð ð \n |

| ( h -- + k -- ) [f](x, y) |.

|_ \ ðx ðy/ _| x=a+[Theta]h, y=b+[Theta]k

The last expression is the remainder after n terms, and in it [Theta]

denotes some particular number between 0 and 1. The results for three

or more variables can be written in the same form. The extension of

Taylor's theorem was given by Lagrange (1797); the form written above

is due to Cauchy (1823). For the validity of the theorem in this form

it is necessary that all the differential coefficients up to the nth

should be continuous in a region bounded by x = a ± h, y = b ± k. When

all the differential coefficients, no matter how high the order, are

continuous in such a region, the theorem leads to an expansion of the

function in a multiple power series. Such expansions are just as

important in analysis, geometry and mechanics as expansions of

functions of one variable. Among the problems which are solved by

means of such expansions are the problem of maxima and minima for

functions of more than one variable (see MAXIMA and MINIMA).

Plane curves.

46. In treatises on the differential calculus much space is usually

devoted to the differential geometry of curves and surfaces. A few

remarks and results relating to the differential geometry of plane

curves are set down here.

(i.) If [psi] denotes the angle which the radius vector drawn from the

origin makes with the tangent to a curve at a point whose polar

coordinates are r, [Theta] and if p denotes the perpendicular from the

origin to the tangent, then

cos [psi] = dr/ds, sin [psi] = r d[Theta]/ds = p/r,

where ds denotes the element of arc. The curve may be determined by an

equation connecting p with r.

(ii.) The locus of the foot of the perpendicular let fall from the

origin upon the tangent to a curve at a point is called the _pedal_ of

the curve with respect to the origin. The angle [psi] for the pedal is

the same as the angle [psi] for the curve. Hence the (p, r) equation

of the pedal can be deduced. If the pedal is regarded as the primary

curve, the curve of which it is the pedal is the "negative pedal" of

the primary. We may have pedals of pedals and so on, also negative

pedals of negative pedals and so on. Negative pedals are usually

determined as envelopes.

(iii.) If [phi] denotes the angle which the tangent at any point makes

with a fixed line, we have

r² = p² + (dp/d[phi])².

(iv.) The "average curvature" of the arc [Delta]s of a curve between

two points is measured by the quotient

| [Delta][phi] |

| ------------ |

| [Delta]s |

where the upright lines denote, as usual, that the absolute value of

the included expression is to be taken, and [phi] is the angle which

the tangent makes with a fixed line, so that [Delta][phi] is the angle

between the tangents (or normals) at the points. As one of the points

moves up to coincidence with the other this average curvature tends to

a limit which is the "curvature" of the curve at the point. It is

denoted by

| d[phi] |

| ------ |

| ds |

Sometimes the upright lines are omitted and a rule of signs is

given:--Let the arc s of the curve be measured from some point along

the curve in a chosen sense, and let the normal be drawn towards that

side to which the curve is concave; if the normal is directed towards

the left of an observer looking along the tangent in the chosen sense

of description the curvature is reckoned positive, in the contrary

case negative. The differential d[phi] is often called the "angle of

contingence." In the 14th century the size of the angle between a

curve and its tangent seems to have been seriously debated, and the

name "angle of contingence" was then given to the supposed angle.

(v.) The curvature of a curve at a point is the same as that of a

certain circle which touches the curve at the point, and the "radius

of curvature" [rho] is the radius of this circle. We have 1/[rho] =

|d[phi]/ds|. The centre of the circle is called the "centre of

curvature"; it is the limiting position of the point of intersection

of the normal at the point and the normal at a neighbouring point,

when the second point moves up to coincidence with the first. If a

circle is described to intersect the curve at the point P and at two

other points, and one of these two points is moved up to coincidence

with P, the circle touches the curve at the point P and meets it in

another point; the centre of the circle is then on the normal. As the

third point now moves up to coincidence with P, the centre of the

circle moves to the centre of curvature. The circle is then said to

"osculate" the curve, or to have "contact of the second order" with it

at P.

(vi.) The following are formulae for the radius of curvature:--

1 | { /dy\² }-3/2 d²y |

----- = | { 1 + ( -- ) } --- |,

[rho] | { \dx/ } dx² |

| dr | | d²p |

[rho] = | r -- | = | p + ------- |.

| dp | | d[phi]² |

(vii.) The points at which the curvature vanishes are "points of

inflection." If P is a point of inflection and Q a neighbouring point,

then, as Q moves up to coincidence with P, the distance from P to the

point of intersection of the normals at P and Q becomes greater than

any distance that can be assigned. The equation which gives the

abscissae of the points in which a straight line meets the curve being

expressed in the form [f](x) = 0, the function [f](x) has a factor (x

- x0)³, where x0 is the abscissa of the point of inflection P, and the

line is the tangent at P. When the factor (x - x0) occurs (n + 1)

times in [f](x), the curve is said to have "contact of the nth order"

with the line. There is an obvious modification when the line is

parallel to the axis of y.

(viii.) The locus of the centres of curvature, or envelope of the

normals, of a curve is called the "evolute." A curve which has a given

curve as evolute is called an "involute" of the given curve. All the

involutes are "parallel" curves, that is to say, they are such that

one is derived from another by marking off a constant distance along

the normal. The involutes are "orthogonal trajectories" of the

tangents to the common evolute.

(ix.) The equation of an algebraic curve of the nth degree can be

expressed in the form u0 + u1 + u2 + ... + u_n = 0, where u0 is a

constant, and u_r is a homogeneous rational integral function of x, y

of the rth degree. When the origin is on the curve, u0 vanishes, and

u1 = 0 represents the tangent at the origin. If u1 also vanishes, the

origin is a double point and u2 = o represents the tangents at the

origin. If u2 has distinct factors, or is of the form a(y - p1x)(y -

p2x), the value of y on either branch of the curve can be expressed

(for points sufficiently near the origin) in a power series, which is

either

p1x + ½ q1x² + ..., or p2x + ½ q2X² + ...,

where q1, ... and q2, ... are determined without ambiguity. If p1 and

p2 are real the two branches have radii of curvature [rho]1, [rho]2

determined by the formulae

1 | | 1 | |

------ = |(1 + p1²)^{-3/2} q1 |, ------ = |(1 + p2²)^{-3/2} q2 |.

[rho]1 | | [rho]2 | |

When p1 and p2 are imaginary the origin is the real point of

intersection of two imaginary branches. In the real figure of the

curve it is an _isolated point_. If u2 is a square, a(y - px)², the

origin is a _cusp_, and in general there is not a series for y in

integral powers of x, which is valid in the neighbourhood of the

origin. The further investigation of cusps and multiple points belongs

rather to analytical geometry and the theory of algebraic functions

than to differential calculus.

(x.) When the equation of a curve is given in the form u0 + u1 + ... +

u_(n-1) + u_n = 0 where the notation is the same as that in (ix.), the

factors of u_n determine the directions of the _asymptotes_. If these

factors are all real and distinct, there is an asymptote corresponding

to each factor. If u_n = L1 L2 ... L_n, where L1, ... are linear in x,

y, we may resolve u_(n-1)/u_n into partial fractions according to the

formula

u_(n-1) A1 A2 A_n

------- = -- + -- + ... + ---,

u{n} L1 L2 L_n

and then L1 + A1 = 0, L2 + A2 = 0, ... are the equations of the

asymptotes. When a real factor of u_n is repeated we may have two

parallel asymptotes or we may have a "parabolic asymptote." Sometimes

the parallel asymptotes coincide, as in the curve x²(x² + y² - a²) =

a^4, where x = 0 is the only real asymptote. The whole theory of

asymptotes belongs properly to analytical geometry and the theory of

algebraic functions.

Integral calculus.

47. The formal definition of an integral, the theorem of the existence

of the integral for certain classes of functions, a list of classes of

"integrable" functions, extensions of the notion of integration to

functions which become infinite or indeterminate, and to cases in

which the limits of integration become infinite, the definitions of

multiple integrals, and the possibility of defining functions by means

of definite integrals--all these matters have been considered in

FUNCTION. The definition of integration has been explained in § 5

above, and the results of some of the simplest integrations have been

given in § 12. A few theorems relating to integrations have been noted

in §§ 34, 35, 36 above.

Methods of integration.

48. The chief methods for the evaluation of indefinite integrals are

the method of integration by parts, and the introduction of new

variables.

From the equation d(uv) = udv + vdu we deduce the equation

_ _

/ dv / du

| u -- dx = uv - | v -- dx,

_/ dx _/ dx

or, as it may be written

_ _ _ _

/ / / du / / \

| uw dx = u | w dx - | -- ( | w dx ) dx.

_/ _/ _/ dx \ _/ /

This is the rule of "integration by parts."

As an example we have

_ _

/ e^(ax) / e^(ax) / x 1 \

| xe^(ax) dx = x ------ - | ------ dx = ( --- - -- ) e^(ax).

_/ a _/ a \ a a² /

When we introduce a new variable z in place of x, by means of an

equation giving x in terms of z, we express [f](x) in terms of z. Let

[phi](z) denote the function of z into which [f](x) is transformed.

Then from the equation

dx

dx = -- dz

dz

we deduce the equation

_ _

/ / dx

| [f](x) dx = | [phi](z) -- dz.

_/ _/ dz

As an example, in the integral

_

/

| [root](1 - x²) dx

_/

put x = sin z; the integral becomes

_ _

/ /

| cos z · cos zdz = | ½(1 + cos 2z)dz = ½(z + ½ sin 2z) = ½(z + sin z cos z).

_/ _/

Integration in terms of elementary functions.

49. The indefinite integrals of certain classes of functions can be

expressed by means of a finite number of operations of addition or

multiplication in terms of the so-called "elementary" functions. The

elementary functions are rational algebraic functions, implicit

algebraic functions, exponentials and logarithms, trigonometrical and

inverse circular functions. The following are among the classes of

functions whose integrals involve the elementary functions only: (i.)

all rational functions; (ii.) all irrational functions of the form

[f](x, y), where [f] denotes a rational algebraic function of x and y,

and y is connected with x by an algebraic equation of the second

degree; (iii.) all rational functions of sin x and cos x; (iv.) all

rational functions of e^x; (v.) all rational integral functions of the

variables x, e^(ax), e^(bx), ... sin mx, cos mx, sin nx, cos nx, ...

in which a, b, ... and m, n, ... are any constants. The integration of

a rational function is generally effected by resolving the function

into partial fractions, the function being first expressed as the

quotient of two rational integral functions. Corresponding to any

simple root of the denominator there is a logarithmic term in the

integral. If any of the roots of the denominator are repeated there

are rational algebraic terms in the integral. The operation of

resolving a fraction into partial fractions requires a knowledge of

the roots of the denominator, but the algebraic part of the integral

can always be found without obtaining all the roots of the

denominator. Reference may be made to C. Hermite, _Cours d'analyse_,

Paris, 1873. The integration of other functions, which can be

integrated in terms of the elementary functions, can usually be

effected by transforming the functions into rational functions,

possibly after preliminary integrations by parts. In the case of

rational functions of x and a radical of the form [root](ax² + bx + c)

the radical can be reduced by a linear substitution to one of the

forms [root](a² - x²), [root](x² - a²), [root](x² + a²). The

substitutions x = a sin [theta], x = a sec [theta], x = a tan [theta]

are then effective in the three cases. By these substitutions the

subject of integration becomes a rational function of sin [theta] and

cos [theta], and it can be reduced to a rational function of t by the

substitution tan ½[theta] = t. There are many other substitutions by

which such integrals can be determined. Sometimes we may have

information as to the functional character of the integral without

being able to determine it. For example, when the subject of

integration is of the form (ax^4 + bx³ + cx² + dx + e)^-½ the integral

cannot be expressed explicitly in terms of elementary functions. Such

integrals lead to new functions (see FUNCTION).

Methods of reduction and substitution for the evaluation of indefinite

integrals occupy a considerable space in text-books of the integral

calculus. In regard to the functional character of the integral

reference may be made to G. H. Hardy's tract, _The Integration of

Functions of a Single Variable_ (Cambridge, 1905), and to the memoirs

there quoted. A few results are added here

_

/

(i.) | (x² + a) - ½ dx = log {x + (x² + a)^½ }.

_/

_

/ dx

(ii.) | -----------------------------

_/ (x - p) [root](ax² + 2bx + c)

can be evaluated by the substitution x - p = 1/z, and

_

/ dx

| ---------------------------------

_/ (x - p)^{n} [root](ax² + 2bx + c)

can be deduced by differentiating (n - 1) times with respect to p.

_

/ (Hx + K)dx

(iii.) | ------------------------------------------------------

_/ ([alpha]x² + 2[beta]x + [gamma]) [root](ax² + 2bx + c)

can be reduced by the substitution y² = (ax² + 2bx + c)/([alpha]x² +

2[beta]x + [gamma]) to the form

_ _

/ dy / dy

A | ---------------------- + B | ----------------------

_/ [root]([lambda]1 - y²) _/ [root](y² - [lambda]2)

where A and B are constants, and [lambda]1 and [lambda]2 are the two

values of [lambda] for which (a - [lambda][alpha])x² + 2(b -

[lambda][beta])x + c - [lambda][gamma] is a perfect square (see A. G.

Greenhill, _A Chapter in the Integral Calculus_, London, 1888).

(iv.) [f]x^m (ax^n + b)^p dx, in which m, n, p are rational, can be

reduced, by putting ax^n = bt, to depend upon [f]t^q (1 + t)^p dt. If

p is an integer and q a fraction r/s, we put t = u^s. If q is an

integer and p = r/s we put 1 + t = u^s. If p + q is an integer and p =

r/s we put 1 + t = tu^s. These integrals, called "binomial integrals,"

were investigated by Newton (_De quadratura curvarum_).

_ _

/ dx x / dx

(v.) | ----- = log tan ---, (vi.) | ----- = log (tan x + sec x).

_/ sin x 2 _/ cos x

(vii.) [f] e^(ax) sin (bx + [alpha]) dx = (a² + b²)^-1 e^(ax){a sin

(bx + [alpha]) - b cos (bx + [alpha])}.

(viii.) [f] sin^m x cos^n x dx can be reduced by differentiating a

function of the form sin^p x cos^q x;

d sin x 1 q sin² x 1 - q q

e.g. -- ------- = ----------- + ----------- = ----------- + -----------.

dx cos^q x cos^(q-1) x cos^(q+1) x cos^(q-1) x cos^(q+1) x

Hence

_ _

/ dx sin x n - 2 / dx

| ------- = ------------------- + ----- | -----------.

_/ cos^n x (n - 1) cos^(n-1) x n - 1 _/ cos^(n-2) x

_ _

/ ½[pi] / ½[pi]

(ix.) | sin^(2n) x dx = | cos^(2n) x dx =

_/ 0 _/ 0

1·3 ... (2n - 1) [pi]

---------------- · ----, (n an integer).

2·4 ... 2n 2

_ _

/ ½[pi] / ½[pi]

(x.) | sin^(2n+1) x dx = | cos^(2n+1) x dx =

_/ 0 _/ 0

2·4 ... (2n)

--------------, (n an integer).

3·5 ... (2n+1)

_

/ dx

(xi.) | --------------- can be reduced by one of the substitutions

_/ (1 + e cos x)^n

e + cos x e + cos x

cos [phi] = -----------, cosh u = -----------,

1 + e cos x 1 + e cos x

of which the first or the second is to be employed according as e < or > 1.

New transcendents.

50. Among the integrals of transcendental functions which lead to new

transcendental functions we may notice

_ _

/ x dx / log x e^z

| ----- or | --- dz,

_/ 0 log x´ _/ -x z

called the "logarithmic integral," and denoted by "Li x," also the

integrals

_ _

/ x sin x / x cos x

| ----- dx and | ----- dx,

_/ 0 x _/ [oo] x

called the "sine integral" and the "cosine integral," and denoted by

"Si x" and "Ci x," also the integral

_

/ x

| e^-x² dx

_/ 0

called the "error-function integral," and denoted by "Erf x." All

these functions have been tabulated (see TABLES, MATHEMATICAL).

Eulerian integrals.

51. New functions can be introduced also by means of the definite

integrals of functions of two or more variables with respect to one of

the variables, the limits of integration being fixed. Prominent among

such functions are the Beta and Gamma functions expressed by the

equations

_

/ 1

B(l, m) = | x^(l-1) (1 - x)^(m-1) dx,

_/ 0

_

/ [oo]

[Gamma](n) = | e^-t t^(n-1) dt.

_/ 0

When n is a positive integer [Gamma](n + 1) = n!. The Beta function

(or "Eulerian integral of the first kind") is expressible in terms of

Gamma functions (or "Eulerian integrals of the second kind") by the

formula

B(l, m)·[Gamma](l+m) = [Gamma](l)·[Gamma](m).

The Gamma function satisfies the difference equation

[Gamma](x + 1) = x [Gamma](x),

and also the equation

[Gamma](x)·[Gamma](1-x) = [pi]/sin (x[pi]),

with the particular result

[Gamma](½)= [root][pi].

The number

_ _

| d |

- | -- {log [Gamma](1 + x)} | , or -[Gamma]´(1),

|_ dx _|x=0

is called "Euler's constant," and is equal to the limit

_ _

| / \ |

lim. | ( 1 + ½ + 1/3 + ... + 1/n ) - log n |;

n=[oo] |_ \ / _|

its value to 15 decimal places is 0.577 215 664 901 532.

The function log [Gamma](1 + x) can be expanded in the series

/ x[pi] \

log [Gamma](1 + x) = ½ log ( --------- )

\ sin x[pi] /

1 + x

- ½ log ----- + {1 + [Gamma]´(1)} x

1 - x

- 1/3 (S3 - 1)x³ - 1/5 (S5 - 1)x^5 - ...,

where

1 1

S_(2r+1) = 1 + -------- + -------- + ...,

2^(2r+1) 3^(2r+1)

and the series for log [Gamma](1 + x) converges when x lies between -

1 and 1.

Definite integrals.

52. Definite integrals can sometimes be evaluated when the limits of

integration are some particular numbers, although the corresponding

indefinite integrals cannot be found. For example, we have the result

_

/ 1

| (1 - x²)^-½ log x dx = -½ [pi] log 2,

_/ 0

although the indefinite integral of (1 - x²)^-½ log x cannot be found.

Numbers of definite integrals are expressible in terms of the

transcendental functions mentioned in § 50 or in terms of Gamma

functions. For the calculation of definite integrals we have the

following methods:--

(i.) Differentiation with respect to a parameter.

(ii.) Integration with respect to a parameter.

(iii.) Expansion in infinite series and integration term by term.

(iv.) Contour integration.

The first three methods involve an interchange of the order of two

limiting operations, and they are valid only when the functions

satisfy certain conditions of continuity, or, in case the limits of

integration are infinite, when the functions tend to zero at infinite

distances in a sufficiently high order (see FUNCTION). The method of

contour integration involves the introduction of complex variables

(see FUNCTION: § _Complex Variables_).

A few results are added

_

/ [oo] x^(a-1) [pi]

(i.) | ------- dx = ---------, (1 > a > 0),

_/ 0 1 + x sin a[pi]

_

/ [oo] x^(a-1) - x^(b-1)

(ii.) | ----------------- dx = [pi](cot a[pi] - cot b[pi]), (0 < a or b < 1),

_/ 0 1 - x

_

/ [oo] x^(a-1) log x [pi]²

(iii.) | ------------ dx = ----------, (a > 1),

_/ 0 x - 1 sin² a[pi]

_

/ [oo]

(iv.) | x²·cos 2x·e^-x² dx = -¼ e^-1 [root][pi],

_/ 0

_

/ 1 1 - x² dx [pi]

(v.) | ------- ----- = log tan ----,

_/ 0 1 + x^4 log x 8

_

/ [oo] sin mx / 1 1 1 \

(vi.) | -------------- dx = ½ ( ------- - --- + --- ),

_/ 0 e^(2[pi]x) - 1 \ e^m - 1 m 2 /

_

/ [pi]

(vii.) | log(1 - 2[alpha] cos x + [alpha]²) dx = 0

_/ 0

or 2[pi]log [alpha] according as [alpha] < or > 1,

_

/ [oo] sin x

(viii.) | ----- dx = ½[pi],

_/ 0 x

_

/ [oo] cos ax

(ix.) | ------- dx = ½[pi]b^-1 e^(-ab),

_/ 0 x² + b²

_

/ [oo] cos ax - cos bx

(x.) | --------------- dx = ½[pi](b - a),

_/ 0 x²

_

/ [oo] cos ax - cos bx b

(xi.) | --------------- dx = log ---,

_/ 0 x a

_

/ [oo] cos x - e ^(-mx)

(xii.) | ---------------- dx = log m,

_/ 0 x

_

/ [oo]

(xiii.) | e^(-x²+2ax) dx = [root][pi].e^(a2),

_/ -[oo]

_ _

/ [oo] / [oo]

(xiv.) | x^-½ sin x dx = | x^-½ cos x dx = [root](½[pi]),

_/ 0 _/ 0

Multiple Integrals.

53. The meaning of integration of a function of n variables through a

domain of the same number of dimensions is explained in the article

FUNCTION. In the case of two variables x, y we integrate a function

[f](x, y) over an area; in the case of three variables x, y, z we

integrate a function [f](x, y, z) through a volume. The integral of a

function [f](x, y) over an area in the plane of (x, y) is denoted by

_ _

/ /

| | [f](x, y) dx dy.

_/_/

The notation refers to a method of evaluating the integral. We may

suppose the area divided into a very large number of very small

rectangles by lines parallel to the axes. Then we multiply the value

of [f] at any point within a rectangle by the measure of the area of

the rectangle, sum for all the rectangles, and pass to a limit by

increasing the number of rectangles indefinitely and diminishing all

their sides indefinitely. The process is usually effected by summing

first for all the rectangles which lie in a strip between two lines

parallel to one axis, say the axis of y, and afterwards for all the

strips. This process is equivalent to integrating [f](x, y) with

respect to y, keeping x constant, and taking certain functions of x as

the limits of integration for y, and then integrating the result with

respect to x between constant limits. The integral obtained in this

way may be written in such a form as

_ _

/ b { / [f]2(x) }

| dx { | [f](x, y) dy },

_/ a { _/ [f]1(x) }

and is called a "repeated integral." The identification of a surface

integral, such as [int][int][f](x, y)dxdy, with a repeated integral

cannot always be made, but implies that the function satisfies certain

conditions of continuity. In the same way volume integrals are usually

evaluated by regarding them as repeated integrals, and a volume

integral is written in the form

_ _ _

/ / /

| | | [f](x, y, z) dx dy dz.

_/_/_/

Integrals such as surface and volume integrals are usually called

"multiple integrals." Thus we have "double" integrals, "triple"

integrals, and so on. In contradistinction to multiple integrals the

ordinary integral of a function of one variable with respect to that

variable is called a "simple integral."

Surface Integrals.

A more general type of surface integral may be defined by taking an

arbitrary surface, with or without an edge. We suppose in the first

place that the surface is closed, or has no edge. We may mark a large

number of points on the surface, and draw the tangent planes at all

these points. These tangent planes form a polyhedron having a large

number of faces, one to each marked point; and we may choose the

marked points so that all the linear dimensions of any face are less

than some arbitrarily chosen length. We may devise a rule for

increasing the number of marked points indefinitely and decreasing the

lengths of all the edges of the polyhedra indefinitely. If the sum of

the areas of the faces tends to a limit, this limit is the area of the

surface. If we multiply the value of a function [f] at a point of the

surface by the measure of the area of the corresponding face of the

polyhedron, sum for all the faces, and pass to a limit as before, the

result is a surface integral, and is written

_ _

/ /

| | [f] dS.

_/_/

Line Integrals.

The extension to the case of an open surface bounded by an edge

presents no difficulty. A line integral taken along a curve is defined

in a similar way, and is written

_

/

| [f] ds

_/

where ds is the element of arc of the curve (§ 33). The direction

cosines of the tangent of a curve are dx/ds, dy/ds, dz/ds, and line

integrals usually present themselves in the form

_ _

/ / dx dy dz \ /

| ( u -- + v -- + w -- ) ds or | (u dx + v dy + w dz).

_/ \ ds ds ds / _/ s

In like manner surface integrals usually present themselves in the

form

_ _

/ /

| | (l[xi] + m[eta] + n[zeta]) dS

_/_/

where l, m, n are the direction cosines of the normal to the surface

drawn in a specified sense.

The area of a bounded portion of the plane of (x, y) may be expressed

either as

_

/

½ | (x dy - y dx),

_/

or as

_ _

/ /

| | dx dy,

_/_/

the former integral being a line integral taken round the boundary of

the portion, and the latter a surface integral taken over the area

within this boundary. In forming the line integral the boundary is

supposed to be described in the positive sense, so that the included

area is on the left hand.

Theorems of Green and Stokes.

53_a_. We have two theorems of transformation connecting volume

integrals with surface integrals and surface integrals with line

integrals. The first theorem, called "Green's theorem," is expressed

by the equation

_ _ _ _ _

/ / / / ð[xi] ð[eta] ð[zeta]\ / /

| | | ( ----- + ------ + ------- )dx dy dz = | | (l[xi] + m[eta] + n[zeta]) dS,

_/_/_/ \ ðx ðy ðz / _/_/

where the volume integral on the left is taken through the volume

within a closed surface S, and the surface integral on the right is

taken over S, and l, m, n denote the direction cosines of the normal

to S drawn outwards. There is a corresponding theorem for a closed

curve in two dimensions, viz.,

_ _ _

/ / / ð[xi] ð[eta]\ / / dy dx \

| | ( ----- + ------ ) dx dy = | ( [xi] -- - [eta] -- ) ds,

_/_/ \ ðx ðy / _/ \ ds ds /

the sense of description of s being the positive sense. This theorem

is a particular case of a more general theorem called "Stokes's

theorem." Let s denote the edge of an open surface S, and let S be

covered with a network of curves so that the meshes of the network are

nearly plane, then we can choose a sense of description of the edge of

any mesh, and a corresponding sense for the normal to S at any point

within the mesh, so that these senses are related like the directions

of rotation and translation in a right-handed screw. This convention

fixes the sense of the normal (l, m, n) at any point on S when the

sense of description of s is chosen. If the axes of x, y, z are a

right-handed system, we have Stokes's theorem in the form

_ _ _

/ / / { /ðw ðv\ /ðu ðw\ /ðv ðu\ }

| (u dx + v dy + w dz) = | | { l( -- - -- ) + m( -- - -- ) + n( -- - -- ) }dS,

_/ s _/_/ { \ðy ðz/ \ðz ðx/ \ðx ðy/ }

where the integral on the left is taken round the curve s in the

chosen sense. When the axes are left-handed, we may either reverse the

sense of l, m, n and maintain the formula, or retain the sense of l,

m, n and change the sign of the right-hand member of the equation. For

the validity of the theorems of Green and Stokes it is in general

necessary that the functions involved should satisfy certain

conditions of continuity. For example, in Green's theorem the

differential coefficients ð[xi]/ðx, ð[eta]/ðy, ð[zeta]/ðz must be

continuous within S. Further, there are restrictions upon the nature

of the curves or surfaces involved. For example, Green's theorem, as

here stated, applies only to simply-connected regions of space. The

correction for multiply-connected regions is important in several

physical theories.

Change of Variables in a Multiple Integral.

54. The process of changing the variables in a multiple integral, such

as a surface or volume integral, is divisible into two stages. It is

necessary in the first place to determine the differential element

expressed by the product of the differentials of the first set of

variables in terms of the differentials of the second set of

variables. It is necessary in the second place to determine the limits

of integration which must be employed when the integral in terms of

the new variables is evaluated as a repeated integral. The first part

of the problem is solved at once by the introduction of the Jacobian.

If the variables of one set are denoted by x1, x2, ..., x_n, and those

of the other set by u1, u2, ..., u_n, we have the relation

ð(x1, x2, ..., x_n)

dx1 dx2 ...dx_n = ------------------- du1 du2 ... du_n.

ð(u1, u2, ..., u_n)

In regard to the second stage of the process the limits of integration

must be determined by the rule that the integration with respect to

the second set of variables is to be taken through the same domain as

the integration with respect to the first set.

For example, when we have to integrate a function [f](x, y) over the

area within a circle given by x² + y² = a², and we introduce polar

coordinates so that x = r cos [theta], y = r sin [theta], we find that

r is the value of the Jacobian, and that all points within or on the

circle are given by a [>=] r [>=] o, 2[pi][>=][theta][>=]o, and we have

_ _ _ _

/ a / [root](a²-x²) / a /2[pi]

| dx | [f](x, y) dy = | dr | f(r cos [theta], r sin [theta]) r d[theta].

_/-a _/-[root](a²-x²) _/ 0 _/ 0

If we have to integrate over the area of a rectangle a [>=] x [>=] 0,

b [>=] y [>=] 0, and we transform to polar coordinates, the integral

becomes the sum of two integrals, as follows:--

_ _ _ _

/a / b /tan^-1 b/a /a sec [theta]

| dx | [f](x, y) dy = | d[theta] | [f](r cos [theta], r sin [theta]) r dr

_/0 _/ 0 _/ 0 _/0

_ _

/ ½[pi] /b cosec [theta]

+ | d[theta] | [f](r cos [theta], r sin [theta]) r dr.

_/tan^-1 b/a _/ 0

55. A few additional results in relation to line integrals and

multiple integrals are set down here.

Line Integrals and Multiple Integrals.

(i.) Any simple integral can be regarded as a line-integral taken

along a portion of the axis of x. When a change of variables is made,

the limits of integration with respect to the new variable must be

such that the domain of integration is the same as before. This

condition may require the replacing of the original integral by the

sum of two or more simple integrals.

(ii.) The line integral of a perfect differential of a one-valued

function, taken along any closed curve, is zero.

(iii.) The area within any plane closed curve can be expressed by

either of the formulae

_ _

/ /

| ½ r² d[theta] or | ½ p ds,

_/ _/

where r, [theta] are polar coordinates, and p is the perpendicular

drawn from a fixed point to the tangent. The integrals are to be

understood as line integrals taken along the curve. When the same

integrals are taken between limits which correspond to two points of

the curve, in the sense of line integrals along the arc between the

points, they represent the area bounded by the arc and the terminal

radii vectores.

(iv.) The volume enclosed by a surface which is generated by the

revolution of a curve about the axis of x is expressed by the formula

_

/

[pi] | y² dx,

_/

and the area of the surface is expressed by the formula

_

/

2[pi] | y ds,

_/

where ds is the differential element of arc of the curve. When the

former integral is taken between assigned limits it represents the

volume contained between the surface and two planes which cut the axis

of x at right angles. The latter integral is to be understood as a

line integral taken along the curve, and it represents the area of the

portion of the curved surface which is contained between two planes at

right angles to the axis of x.

(v.) When we use curvilinear coordinates [xi], [eta] which are

conjugate functions of x, y, that is to say are such that

ð[xi]/ðx = ð[eta]/ðy and ð[xi]/ðy = -ð[eta]/ðx,

the Jacobian ð([xi], [eta])/ð(x, v) can be expressed in the form

/ð[xi]\² /ð[eta]\²

( ----- ) + ( ------ ),

\ ðx / \ ðx /

and in a number of equivalent forms. The area of any portion of the

plane is represented by the double integral

_ _

/ /

| | J^-1 d[xi] d[eta],

_/_/

where J denotes the above Jacobian, and the integration is taken

through a suitable domain. When the boundary consists of portions of

curves for which [xi] = const., or [eta] = const., the above is

generally the simplest way of evaluating it.

(vi.) The problem of "rectifying" a plane curve, or finding its

length, is solved by evaluating the integral

_

/ { /dy\² }½

| { 1 + ( -- ) } dx,

_/ { \dx/ }

or, in polar coordinates, by evaluating the integral

_

/ { / dr \² }½

| { r² + ( -------- ) } d[theta].

_/ { \d[theta]/ }

In both cases the integrals are line integrals taken along the curve.

(vii.) When we use curvilinear coordinates [xi], [eta] as in (v.)

above, the length of any portion of a curve [xi] = const. is given by

the integral

_

/

| J^-½ d[eta]

_/

taken between appropriate limits for [eta]. There is a similar formula

for the arc of a curve [eta] = const.

(viii.) The area of a surface z = [f](x, y) can be expressed by the

formula

_ _

/ / { /ðz\² /ðz\² }½

| | { 1 + ( -- ) + ( -- ) } dx dy.

_/_/ { \ðx/ \ðy/ }

When the coordinates of the points of a surface are expressed as

functions of two parameters u, v, the area is expressed by the

formula

_ _ _ _

/ / | { ð(y, z) }² { ð(z, x) }² { ð(x, y) }² |½

| | | { ------- } + { ------- } + { ------- } | du dv.

_/_/ |_ { ð(u, v) } { ð(u, v) } { ð(u, v) } _|

When the surface is referred to three-dimensional polar coordinates r,

[theta], [phi] given by the equations

x = r sin [theta] cos [phi], y = r sin [theta] sin [phi],

z = r cos [theta],

and the equation of the surface is of the form r = [f]([theta],

[phi]), the area is expressed by the formula

_ _ _ _

/ / | { / ðr \² } / ðr \² |½

| | r | { r² + ( -------- ) } sin² [theta] + ( ------ ) | d[theta] d[phi].

_/_/ |_ { \ð[theta]/ } \ð[phi]/ _|

The surface integral of a function of ([theta], [phi]) over the

surface of a sphere r = const. can be expressed in the form

_ _

/2[pi] /[pi]

| d[phi] | F([theta], [phi]) r² sin [theta] d[theta].

_/ 0 _/ 0

In every case the domain of integration must be chosen so as to

include the whole surface.

(ix.) In three-dimensional polar coordinates the Jacobian

ð(x, y, z)

-------------------- = r² sin [theta]

ð(r, [theta], [phi])

The volume integral of a function F (r, [theta], [phi]) through the

volume of a sphere r = a is

_ _ _

/ a /2[pi] /[pi]

| dr | d[phi] | F(r, [theta], [phi]) r² sin [theta] d[theta].

_/ 0 _/ 0 _/ 0

(x.) Integrations of rational functions through the volume of an

ellipsoid x²/a² + y²/b² + z²/c² = 1 are often effected by means of a

general theorem due to Lejeune Dirichlet (1839), which is as follows:

when the domain of integration is that given by the inequality

/x1\[alpha]1 /x2\^[alpha]2 /x_n\[alpha]_n

( -- ) + ( -- ) + ... + ( --- ) [<=] 1

\a1/ \a2/ \a_n/

where the a's and [alpha]'s are positive, the value of the integral

_ _

/ /

| | ... x1^(n1-1)·x2^(n2-1) ... dx1 dx2 ...

_/_/

a1^(n1) a2^(n2) ... [Gamma] (n1/[alpha]1) [Gamma] (n2/[alpha]2)

is --------------------- ---------------------------------------------.

[alpha]1 [alpha]2 ... [Gamma](1 + n1/[alpha]1 + n2/[alpha]2 + ... )

If, however, the object aimed at is an integration through the volume

of an ellipsoid it is simpler to reduce the domain of integration to

that within a sphere of radius unity by the transformation x = a[xi],

y = b[eta], z = c[zeta], and then to perform the integration through

the sphere by transforming to polar coordinates as in (ix).

Approximate and Mechanical Integration.

56. Methods of approximate integration began to be devised very early.

Kepler's practical measurement of the focal sectors of ellipses (1609)

was an approximate integration, as also was the method for the

quadrature of the hyperbola given by James Gregory in the appendix to

his _Exercitationes geometricae_ (1668). In Newton's _Methodus

differentialis_ (1711) the subject was taken up systematically.

Newton's object was to effect the approximate quadrature of a given

curve by making a curve of the type

y = a0 + a1x + a2x² + ... + a_n x^n

pass through the vertices of (n + 1) equidistant ordinates of the

given curve, and by taking the area of the new curve so determined as

an approximation to the area of the given curve. In 1743 Thomas

Simpson in his _Mathematical Dissertations_ published a very

convenient rule, obtained by taking the vertices of three consecutive

equidistant ordinates to be points on the same parabola. The distance

between the extreme ordinates corresponding to the abscissae x = a and

x = b is divided into 2n equal segments by ordinates y1, y2, ...

y(2n-1), and the extreme ordinates are denoted by y0, y(2n). The

vertices of the ordinates y0, y1, y2 lie on a parabola with its axis

parallel to the axis of y, so do the vertices of the ordinates y2, y3,

y4, and so on. The area is expressed approximately by the formula

{(b - a)/6n} [y0 + y_(2n) + 2 (y2 + y4 + ... + y_(2n-2))

+ 4(y1 + y3 + ... + y_(2n-1)],

which is known as Simpson's rule. Since all simple integrals can be

represented as areas such rules are applicable to approximate

integration in general. For the recent developments reference may be

made to the article by A. Voss in _Ency. d. Math. Wiss._, Bd. II., A.

2 (1899), and to a monograph by B. P. Moors, _Valeur approximative

d'une intégrale définie_ (Paris, 1905).

Many instruments have been devised for registering mechanically the

areas of closed curves and the values of integrals. The best known are

perhaps the "planimeter" of J. Amsler (1854) and the "integraph" of

Abdank-Abakanowicz (1882).

BIBLIOGRAPHY.--For historical questions relating to the subject the

chief authority is M. Cantor, _Geschichte d. Mathematik_ (3 Bde.,

Leipzig, 1894-1901). For particular matters, or special periods, the

following may be mentioned: H. G. Zeuthen, _Geschichte d. Math. im

Altertum u. Mittelalter_ (Copenhagen, 1896) and _Gesch. d. Math. im

XVI. u. XVII. Jahrhundert_ (Leipzig, 1903); S. Horsley, _Isaaci

Newtoni opera quae exstant omnia_ (5 vols., London, 1779-1785); C. I.

Gerhardt, _Leibnizens math. Schriften_ (7 Bde., Leipzig, 1849-1863);

Joh. Bernoulli, _Opera omnia_ (4 Bde., Lausanne and Geneva, 1742).

Other writings of importance in the history of the subject are cited

in the course of the article. A list of some of the more important

treatises on the differential and integral calculus is appended. The

list has no pretensions to completeness; in particular, most of the

recent books in which the subject is presented in an elementary way

for beginners or engineers are omitted.--L. Euler, _Institutiones

calculi differentialis_ (Petrop., 1755) and _Institutiones calculi

integralis_ (3 Bde., Petrop., 1768-1770); J. L. Lagrange, _Leçons sur

le calcul des fonctions_ (Paris, 1806, _Oeuvres_, t. x.), and _Théorie

des fonctions analytiques_ (Paris, 1797, 2nd ed., 1813, _Oeuvres_, t.

ix.); S. F. Lacroix, _Traité de calcul diff. et de calcul int._ (3

tt., Paris, 1808-1819). There have been numerous later editions; a

translation by Herschel, Peacock and Babbage of an abbreviated edition

of Lacroix's treatise was published at Cambridge in 1816. G. Peacock,

_Examples of the Differential and Integral Calculus_ (Cambridge,

1820); A. L. Cauchy, _Résumé des leçons ... sur le calcul

infinitésimale_ (Paris, 1823), and _Leçons sur le calcul différentiel_

(Paris, 1829; _Oeuvres_, sér. 2, t. iv.); F. Minding, _Handbuch d.

Diff.-u. Int.-Rechnung_ (Berlin, 1836); F. Moigno, _Leçons sur le

calcul diff._ (4 tt., Paris, 1840-1861); A. de Morgan, _Diff. and Int.

Calc._ (London, 1842); D. Gregory, _Examples on the Diff. and Int.

Calc._ (2 vols., Cambridge, 1841-1846); I. Todhunter, _Treatise on the

Diff. Calc._ and _Treatise on the Int. Calc._ (London, 1852), numerous

later editions; B. Price, _Treatise on the Infinitesimal Calculus_ (2

vols., Oxford, 1854), numerous later editions; D. Bierens de Haan,

_Tables d'intégrales définies_ (Amsterdam, 1858); M. Stegemann,

_Grundriss d. Diff.- u. Int.-Rechnung_ (2 Bde., Hanover, 1862)

numerous later editions; J. Bertrand, _Traité de calc. diff. et int._

(2 tt., Paris, 1864-1870); J. A. Serret, _Cours de calc. diff. et

int._ (2 tt., Paris, 1868, 2nd ed., 1880, German edition by Harnack,

Leipzig, 1884-1886, later German editions by Bohlmann, 1896, and

Scheffers, 1906, incomplete); B. Williamson, _Treatise on the Diff.

Calc._ (Dublin, 1872), and _Treatise on the Int. Calc._ (Dublin, 1874)

numerous later editions of both; also the article "Infinitesimal

Calculus" in the 9th ed. of the _Ency. Brit._; C. Hermite, _Cours

d'analyse_ (Paris, 1873); O. Schlömilch, _Compendium d. höheren

Analysis_ (2 Bde., Leipzig, 1874) numerous later editions; J. Thomae,

_Einleitung in d. Theorie d. bestimmten Integrale_ (Halle, 1875); R.

Lipschitz, _Lehrbuch d. Analysis_ (2 Bde., Bonn, 1877, 1880); A.

Harnack, _Elemente d. Diff.- u. Int.-Rechnung_ (Leipzig, 1882, Eng.

trans. by Cathcart, London, 1891); M. Pasch, _Einleitung in d. Diff.-

u. Int.-Rechnung_ (Leipzig, 1882); Genocchi and Peano, _Calcolo

differenziale_ (Turin, 1884, German edition by Bohlmann and Schepp,

Leipzig, 1898, 1899); H. Laurent, _Traité d'analyse_ (7 tt., Paris,

1885-1891); J. Edwards, _Elementary Treatise on the Diff. Calc._

(London, 1886), several later editions; A. G. Greenhill, _Diff. and

Int. Calc._ (London, 1886, 2nd ed., 1891); É. Picard, _Traité

d'analyse_ (3 tt., Paris, 1891-1896); O. Stolz, _Grundzüge d. Diff.-

u. Int.-Rechnung_ (3 Bde., Leipzig, 1893-1899); C. Jordan, _Cours

d'analyse_ (3 tt., Paris, 1893-1896); L. Kronecker, _Vorlesungen ü. d.

Theorie d. einfachen u. vielfachen Integrale_ (Leipzig, 1894); J.

Perry, _The Calculus for Engineers_ (London, 1897); H. Lamb, _An

Elementary Course of Infinitesimal Calculus_ (Cambridge, 1897); G. A.

Gibson, _An Elementary Treatise on the Calculus_ (London, 1901); É.

Goursat, _Cours d'analyse mathématique_ (2 tt., Paris, 1902-1905);

C.-J. de la Vallée Poussin, _Cours d'analyse infinitésimale_ (2 tt.,

Louvain and Paris, 1903-1906); A. E. H. Love, _Elements of the Diff.

and Int. Calc._ (Cambridge, 1909); W. H. Young, _The Fundamental

Theorems of the Diff. Calc._ (Cambridge, 1910). A résumé of the

infinitesimal calculus is given in the articles "Diff.- u.

Int-Rechnung" by A. Voss, and "Bestimmte Integrale" by G. Brunel in

_Ency. d. math. Wiss._ (Bde. ii. A. 2, and ii. A. 3, Leipzig, 1899,

1900). Many questions of principle are discussed exhaustively by E. W.

Hobson, _The Theory of Functions of a Real Variable_ (Cambridge,

1907). (A. E. H. L.)

INFINITIVE, a form of the verb, properly a noun with verbal functions,

but usually taken as a mood (see GRAMMAR). The Latin grammarians gave it

the name of _infinitus_ or _infinitivus modus_, i.e. indefinite,

unlimited mood, as not having definite persons or numbers.

INFLEXION (from Lat. _inflectere_, to bend), the action of bending

inwards, or turning towards oneself, or the condition of being bent or

curved. In optics, the term "inflexion" was used by Newton for what is

now known as "diffraction of light" (q.v.). For inflexion in geometry

see CURVE. Inflexion when used of the voice, in speaking or singing,

indicates a change in tone, pitch or expression. In grammar (q.v.)

inflexion indicates the changes which a word undergoes to bring it into

correct relations with the other words with which it is used. In English

grammar nouns, pronouns, adjectives (in their degrees of comparison),

verbs and adverbs are inflected. Some grammarians, however, regard the

inflexions of adverbs more as an actual change in word-formation.

INFLUENCE (Late Lat. _influentia_, from _influere_, to flow in), a word

whose principal modern meaning is that of power, control or action

affecting others, exercised either covertly or without visible means or

direct physical agency. It is one of those numerous terms of astrology

(q.v.) which have established themselves in current language. From the

stars was supposed to flow an ethereal stream which affected the course

of events on the earth and the fortunes and characters of men. For the

law as to "undue influence" see CONTRACT.

INFLUENZA (syn. "grip," _la grippe_), a term applied to an infectious

febrile disorder due to a specific bacillus, characterized specially by

catarrh of the respiratory passages and alimentary canal, and occurring

mostly as an epidemic. The Italians in the 17th century ascribed it to

the influence of the stars, and hence the name "influenza." The French

name _grippe_ came into use in 1743, and those of _petite poste_ and

_petit courier_ in 1762, while _général_ became another synonym in 1780.

Apparently the scourge was common; in 1403 and 1557 the sittings of the

Paris law courts had to be suspended through it, and in 1427 sermons had

to be abandoned through the coughing and sneezing; in 1510 masses could

not be sung. Epidemics occurred in 1580, 1676, 1703, 1732 and 1737, and

their cessation was supposed to be connected with earthquakes and

volcanic eruptions.

The disease is referred to in the works of the ancient physicians, and

accurate descriptions of it have been given by medical writers during

the last three centuries. These various accounts agree substantially in

their narration of the phenomena and course of the disease, and

influenza has in all times been regarded as fulfilling all the

conditions of an epidemic in its sudden invasion, and rapid and

extensive spread. Among the chief epidemics were those of 1762, 1782,

1787, 1803, 1833, 1837 and 1847. It appeared in fleets at sea away from

all communication with land, and to such an extent as to disable them

temporarily for service. This happened in 1782 in the case of the

squadron of Admiral Richard Kempenfelt (1718-1782), which had to return

to England from the coast of France in consequence of influenza

attacking his crews.

Like cholera and plague, influenza reappeared in the last quarter of the

19th century, after an interval of many years, in epidemic or rather

pandemic form. After the year 1848, in which 7963 deaths were directly

attributed to influenza in England and Wales, the disease continued

prevalent until 1860, with distinct but minor epidemic exacerbations in

1851, 1855 and 1858; during the next decade the mortality dropped

rapidly though not steadily, and the diminution continued down to the

year 1889, In which only 55 deaths were ascribed to this cause. It is

not clear whether the disease ever disappears wholly, and the deaths

registered in 1889 are the lowest recorded in any year since the

registrar-general's returns began. Occasionally local outbreaks of

illness resembling epidemic influenza have been observed during the

period of abeyance, as in Norfolk in 1878 and in Yorkshire in 1887; but

whether such outbreaks and the so-called "sporadic" cases are

nosologically identical with epidemic influenza is open to doubt. The

relation seems rather to be similar to that between Asiatic cholera and

"cholera nostras." Individual cases may be indistinguishable, but as a

factor in the public health the difference between sporadic and epidemic

influenza is as great and unmistakable as that between the two forms of

cholera. This fact, which had been forgotten by some since 1847 and

never learnt by others, was brought home forcibly to all by the

visitation of 1889.

According to the exhaustive report drawn up by Dr H. Franklin Parsons

for the Local Government Board, the earliest appearances were observed

in May 1889, and three localities are mentioned as affected at the same

time, all widely separated from each other--namely, Bokhara in Central

Asia, Athabasca in the north-west Territories of Canada and Greenland.

About the middle of October it was reported at Tomsk in Siberia, and by

the end of the month at St Petersburg. During November Russia became

generally affected, and cases were noticed in Paris, Berlin, Vienna,

London and Jamaica (?). In December epidemic influenza became

established over the whole of Europe, along the Mediterranean, in Egypt

and over a large area in the United States. It appeared in several towns

in England, beginning with Portsmouth, but did not become generally

epidemic until the commencement of the new year. In London the full

onset of unmistakable influenza dated from the 1st of January 1890.

Everywhere it seems to have exhibited the same explosive character when

once fully established. In St Petersburg, out of a government staff of

260 men, 220 were taken ill in one night, the 15th of November. During

January 1890 the epidemic reached its height in London, and appeared in

a large number of towns throughout the British Islands, though it was

less prevalent in the north and north-west than in the south. January

witnessed a great extension of the disease in Germany, Holland,

Switzerland, Austria-Hungary, Italy, Spain and Portugal; but in Russia,

Scandinavia and France it was already declining. The period of greatest

activity in Europe was the latter half of December and the earlier half

of January, with the change of the year for a central point. Other parts

of the world affected in January 1890 were Cape Town, Canada, the United

States generally, Algiers, Tunis, Cairo, Corsica, Sardinia, Sicily,

Honolulu, Mexico, the West Indies and Montevideo. In February the

provincial towns of England were most severely affected, the death-rate

rising to 27.4, but in London it fell from 28.1 to 21.2, and for Europe

generally the back of the epidemic was broken. At the same time,

however, it appeared in Ceylon, Penang, Japan, Hong Kong and India; also

in West Africa, attacking Sierra Leone, and Gambia in the middle of the

month; and finally in the west, where Newfoundland and Buenos Aires were

invaded. In March influenza became widely epidemic in India,

particularly in Bengal and Bombay, and made its appearance in Australia

and New Zealand. In April and May it was epidemic all over Australasia,

in Central America, Brazil, Peru, Arabia and Burma. During the summer

and autumn it reached a number of isolated islands, such as Iceland, St

Helena, Mauritius and Réunion. Towards the close of the year it was

reported from Yunnan in the interior of China, from the Shiré Highlands

in Central Africa, Shoa in Abyssinia, and Gilgit in Kashmir. In the

course of fifteen months, beginning with its undoubted appearance in

Siberia in October 1889, it had traversed the entire globe.

The localities attacked by influenza in 1889-1890 appear in no case to

have suffered severely for more than a month or six weeks. Thus in

Europe and North America generally the visitation had come to an end in

the first quarter of 1890. The earliest signs of an epidemic revival on

a large scale occurred in March 1891, in the United States and the north

of England. It was reported from Chicago and other large towns in the

central states, whence it spread eastwards, reaching New York about the

end of March. In England it began in the Yorkshire towns, particularly

in Hull, and also independently in South Wales. In London influenza

became epidemic for the second time about the end of April, and soon

afterwards was widely distributed in England and Wales. The large towns

in the north, together with London and Wales, suffered much more heavily

in mortality than in the previous attack, but the south-west of England,

Scotland and Ireland escaped with comparatively little sickness. The

same may be said of the European continent generally, except parts of

Russia, Scandinavia and perhaps the north of Germany. This second

epidemic coincided with the spring and early summer; it had subsided in

London by the end of June. The experience of Sheffield is interesting.

In 1890 the attack, contrary to general experience, had been undecided,

lingering and mild; in 1891 it was very sudden and extremely severe, the

death-rate rising to 73.4 during the month of April, and subsiding with

equal rapidity. During the third quarter of the year, while Europe was

free, the antipodes had their second attack, which was more severe than

the first. As in England, it reversed the previous order of things,

beginning in the provinces and spreading thence to the capital towns.

The last quarter of the year was signalized by another recrudescence in

Europe, which reached its height during the winter. All parts, including

Great Britain, were severely affected. In England those parts which had

borne the brunt of the epidemic in the early part of the year escaped.

In fact, these two revivals may be regarded as one, temporarily

interrupted by the summer quarter.

The recrudescence at the end of 1891 lasted through mid-winter, and in

many places, notably in London, it only reached its height in January

1892, subsiding slowly and irregularly in February and March. Brighton

suffered with exceptional severity. The continent of Europe seems to

have been similarly affected. In Italy the notifications of influenza

were as follow: 1891--January to October, 0; November, 30; December,

6461; 1892--January, 84,543; February, 55,352; March, 28,046; April,

7962; May, 1468; June, 223. Other parts of the world affected were the

West Indies, Tunis, Egypt, Sudan, Cape Town Teheran, Tongking and China.

In August 1892 influenza was reported from Peru, and later in the year

from various places in Europe.

A fourth recrudescence, but of a milder character, occurred in Great

Britain in the spring of 1893, and a fifth in the following winter, but

the year 1894 was freer from influenza than any since 1890. In 1895

another extensive epidemic took place. In 1896 influenza seemed to have

spent its strength, but there was an increased prevalence of the disease

in 1897, which was repeated on a larger scale in 1898, and again in

1899, when 12,417 deaths were recorded in England and Wales. This was

the highest death-rate since 1892. After this the death-rate declined to

half that amount and remained there with the slight upward variations

until 1907, in which the total death-rate was 9257. The experience of

other countries has been very similar; they have all been subjected to

periodical revivals of epidemic influenza at irregular intervals and of

varying intensity since its reappearance in 1889, but there has been a

general though not a steady decline in its activity and potency. Its

behaviour is, in short, quite in keeping with the experience of

1847-1860, though the later visitation appears to have been more violent

and more fatal than the former. Its diffusion was also more rapid and

probably more extensive.

The foregoing general summary may be supplemented by some further

details of the incidence in Great Britain. The number of deaths directly

attributed to influenza, and the death-rates per million in each year in

England and Wales, are as follow:--

+------+--------+-------------+

| Year.| Deaths.| Death-rates |

| | | per million.|

+------+--------+-------------+

| 1890 | 4,523 | 157 |

| 1891 | 16,686 | 574 |

| 1892 | 15,737 | 534 |

| 1893 | 9,669 | 325 |

| 1894 | 6,625 | 220 |

| 1895 | 12,880 | 424 |

| 1896 | 3,753 | 122 |

| 1897 | 6,088 | 196 |

| 1898 | 10,405 | 331 |

| 1899 | 12,417 | 389 |

| 1900 | 16,245 | 504 |

| 1901 | 5,666 | 174 |

| 1902 | 7,366 | 223 |

| 1903 | 6,322 | 189 |

| 1904 | 5,694 | 168 |

| 1905 | 6,953 | 204 |

| 1906 | 6,310 | 183 |

| 1907 | 9,257 | 265 |

+------+--------+-------------+

It is interesting to compare these figures with the corresponding ones

for the previous visitation:--

+------+--------+-------------+

| Year.| Deaths.| Death-rates |

| | | per million.|

+------+--------+-------------+

| 1847 | 4,881 | 285 |

| 1848 | 7,963 | 460 |

| 1849 | 1,611 | 92 |

| 1850 | 1,380 | 78 |

| 1851 | 2,152 | 120 |

| 1852 | 1,359 | 76 |

| 1853 | 1,789 | 99 |

| 1854 | 1,061 | 58 |

| 1855 | 3,568 | 193 |

+------+--------+-------------+

The two sets of figures are not strictly comparable, because, during the

first period, notification of the cause of death was not compulsory; but

it seems clear that the later wave was much the more deadly. The average

annual death-rate for the nine years is 320 in the one case against 162

in the other, or as nearly as possible double. In both epidemic periods

the second year was far more fatal than the first, and in both a marked

revival took place in the ninth year; in both also an intermediate

recrudescence occurred, in the fifth year in one case, in the sixth in

the other. The chief point of difference is the sudden and marked drop

in 1849-1850, against a persistent high mortality in 1892-1893,

especially in 1892, which was nearly as fatal as 1891.

To make the significance of these epidemic figures clear, it should be

added that in the intervening period 1861-1889 the average annual

death-rate from influenza was only fifteen, and in the ten years

immediately preceding the 1890 outbreak it was only three. Moreover, in

epidemic influenza, the mortality directly attributed to that disease is

only a fraction of that actually caused by it. For instance, in January

1890 the deaths from influenza in London were 304, while the excess of

deaths from respiratory diseases was 1454 and from all causes 1958 above

the average.

We have seen above that the mortality was far greater in the second

epidemic year than in the first, and this applies to all parts of

England, and to rural as well as to urban communities, as the following

table shows:--

_Deaths from Influenza._

+--------------------------------------+------+------+

| | 1890.| 1891.|

+--------------------------------------+------+------+

| London | 624 | 2302 |

| 24 Great Towns over 80,000 population| 439 | 2417 |

| 35 Towns between 20,000 and 80,000 | 186 | 765 |

| 21 Towns between 10,000 and 20,000 | 46 | 196 |

| 60 Towns under 10,000 | 62 | 196 |

| 85 Rural Sanitary Districts | 317 | 841 |

+--------------------------------------+------+------+

In spite of these figures, it appears that the 1890 attack, which was in

general much more sudden in its onset than that of 1891, also caused a

great deal more sickness. More people were "down with influenza," though

fewer died. For Instance, the number of persons treated at the Middlesex

Hospital in the two months' winter epidemic of 1890 was 1279; in the far

more fatal three months' spring epidemic of 1891 it was only 726. One

explanation of this discrepancy between the incidence of sickness and

mortality is that in the second attack, which was more protracted and

more insidious, the stress of the disease fell more upon the lungs.

Another is that its comparative mildness, combined with the time of

year, in itself proved dangerous, because it tempted people to disregard

the illness, whereas in the first epidemic they were too ill to resist.

On the whole, rural districts showed a higher death-rate than towns, and

small towns a higher one than large ones in both years. This is

explained by the age distribution in such localities; influenza being

particularly fatal to aged people, though no age is exempt. Certain

counties were much more severely affected than others. The eastern

counties, namely, Essex, Suffolk and Norfolk, together with Hampshire

and one or two others, escaped lightly in both years; the western

counties, namely, North and South Wales, with the adjoining counties of

Monmouth, Hereford and Shropshire, suffered heavily in both years.

It will be convenient to discuss _seriatim_ the various points of

interest on which light has been thrown by the experience described

above.

The bacteriology of influenza is discussed in the article on PARASITIC

DISEASES. The disease is often called "Russian" influenza, and its

origin in 1889 suggests that the name may have some foundation in fact.

A writer, who saw the epidemic break out in Bokhara, is quoted by him to

the following effect:--"The summer of 1888 was exceptionally hot and

dry, and was followed by a bitterly cold winter and a rainy spring. The

dried-up earth was full of cracks and holes from drought and subsequent

frost, so that the spring rains formed ponds in these holes, inundated

the new railway cuttings, and turned the country into a perfect marsh.

When the hot weather set in the water gave off poisonous exhalations,

rendering malaria general." On account of the severe winter, the people

were enfeebled from lack of nourishment, and when influenza broke out

suddenly they died in large numbers. Europeans were very severely

affected. Russians, hurrying home, carried the disease westwards, and

caravans passing eastwards took it into Siberia. There is a striking

similarity in the conditions described to those observed in connexion

with outbreaks of other diseases, particularly typhoid fever and

diphtheria, which have occurred on the supervention of heavy rain after

a dry period, causing cracks and fissures in the earth. Assuming the

existence of a living poison in the ground, we can easily understand

that under certain conditions, such as an exceptionally dry season, it

may develop exceptional properties and then be driven out by the

subsequent rains, causing a violent outbreak of illness. Some such

explanation is required to account for the periodical occurrence of

epidemic and pandemic diffusions starting from an endemic centre. We may

suppose that a micro-organism of peculiar robustness and virulence is

bred and brought into activity by a combination of favourable

conditions, and is then disseminated more or less widely according to

its "staying power," by human agency. Whether central Asia is an endemic

centre for influenza or not there is no evidence, but the disease seems

to be more often prevalent in the Russian Empire than elsewhere.

Extensive outbreaks occurred there in 1886 and 1887, and it is certain

that the 1889 wave was active in Siberia at an earlier date than in

Europe, and that it moved eastwards. The hypothesis that it originated

in China is unsupported by evidence. But whatever may be the truth with

regard to origin, the dissemination of influenza by human agency must be

held to be proved. This is the most important addition to our knowledge

of the subject contributed by recent research. The upshot of the inquiry

by Dr Parsons was to negative all theories of atmospheric influence, and

to establish the conclusion that the disease was "propagated mainly,

perhaps entirely, by human intercourse."

He found that it prevailed independently of climate, season and

weather; that it moved in a contrary direction to the prevailing

winds; that it travelled along the lines of human intercourse, and not

faster than human beings can travel; that in 1889 it travelled much

faster than in previous epidemics, when the means of locomotion were

very inferior; that it appeared first in capital towns, seaports and

frontier towns, and only affected country districts later; that it

never commenced suddenly with a large number of cases in a place

previously free from disease, but that epidemic manifestations were

generally preceded for some days or weeks by scattered cases; that

conveyance of infection by individuals and its introduction into fresh

places had been observed in many instances; that persons brought much

into contact with others were generally the first to suffer; that

persons brought together in large numbers in enclosed spaces suffered

more in proportion than others, and that the rapidity and extent of

the outbreak in institutions corresponded with the massing together of

the inmates.

These conclusions, based upon the 1889-1890 epidemic, have been

confirmed by subsequent experience, especially in regard to the complete

independence of season and weather shown by influenza. It has appeared

and disappeared at all seasons and in all weathers and only popular

ignorance continues to ascribe its behaviour to atmospheric conditions.

In Europe, however, it has prevailed more often in winter than in

summer, which may be due to the greater susceptibility of persons in

winter, or, more probably, to the fact that they congregate more in

buildings and are less in the open air during that part of the year. No

doubt is any longer entertained of its infectious character, though the

degree of infectivity appears to vary considerably. Many cases have been

recorded of individuals introducing it into houses, and of all or most

of the other inmates then taking it from the first case. Difficulties in

preventing the spread of infection are due to (1) the shortness of the

period of incubation, (2) the disease being infectious in the earliest

stages before the nature of the illness is recognized, (3) the milder

varieties being equally infectious with the severe attacks, and the

patient going to work and spreading the infection, (4) the diagnosis

often being difficult, influenza being possibly confused with ordinary

catarrhal attacks, typhoid fever and other diseases. Domestic animals

seem to be free from any suspicion of being liable to human influenza.

Sanitary conditions, other than overcrowding, do not appear to exercise

any influence on the spread of influenza.

Influenza has been shown to be an acute specific fever having nothing

whatever to do with a "bad cold." There may be some inflammation of the

respiratory passages, and then symptoms of catarrh are present, but that

is not necessarily the case, and in some epidemics such symptoms are

quite exceptional. This had been recognized by various writers before

the 1889 visitation, but it had not been generally realized, as it has

been since, and some medical authorities, who persisted in regarding

influenza as essentially a "catarrhal" affection, were chiefly to blame

for a widespread and tenacious popular fallacy.

Leichtenstern, in his masterly article in Nothnagel's _Handbuch_,

divides the disease as follows:--(1) Epidemic influenza vera caused by

Pfeiffer's bacillus; (2) Endemic-epidemic influenza vera, which occurs

several years after a pandemic and is caused by the same bacillus; (3)

Endemic influenza nostras or eatarrhal fever, called _la grippe_, and

bearing the same relation to true influenza as cholera nostras does to

Asiatic cholera.

The "period of incubation" is one to four days. Susceptibility varies

greatly, but the conditions that influence it are matters of conjecture

only. It appears that the inhabitants of Great Britain are less

susceptible than those of many other countries. Dr Parsons gives the

following list, showing the proportion of the population estimated to

have been attacked in the 1889-1890 epidemic in different localities:--

+---------------------+---------+---------------------+---------+

| Place. |Per cent.| Place. |Per cent.|

+---------------------+---------+---------------------+---------+

| St Petersburg | 50 | Portugal | 90 |

| Berlin | 33 | Vienna | 30-40 |

| Nuremberg | 67 | Belgrade | 33 |

| Grand-Duchy of Hesse| 25-30 | Antwerp | 33 |

| Grand-Duchy, other | | Gaeta | 50-77 |

| Districts | 50-75 | Massachusetts | 39 |

| Heligoland | 50 | Peking | 50 |

| Budapest | 50 | St Louis (Mauritius)| 67 |

+---------------------+---------+---------------------+---------+

In and about London he reckoned roughly from a number of returns that

the proportion was about 12½% among those employed out of doors and

25% among those in offices, &c. The proportion among the troops in the

Home District was 9.3%. The General Post Office made the highest return

with 33.6%, which is accounted for partly by the enormous number of

persons massed together in the same room in more than one department,

and partly by the facilities for obtaining medical advice, which would

tend to bring very light cases, unnoticed elsewhere, upon the record. No

public service was seriously disorganized in England by sickness in the

same manner as on the continent of Europe. Some individuals appear to be

totally immune; others take the disease over and over again, deriving no

immunity, but apparently greater susceptibility from previous attacks.

The symptoms were thus described by Dr Bruce Low from observations made

in St Thomas's Hospital, London, in January 1890:--

The invasion is sudden; the patients can generally tell the time when

they developed the disease; e.g. acute pains in the back and loins

came on quite suddenly while they were at work or walking in the

street, or in the case of a medical student, while playing cards,

rendering him unable to continue the game. A workman wheeling a barrow

had to put it down and leave it; and an omnibus driver was unable to

pull up his horses. This sudden onset is often accompanied by vertigo

and nausea, and sometimes actual vomiting of bilious matter. There are

pains in the limbs and general sense of aching all over; frontal

headache of special severity; pains in the eyeballs, increased by the

slightest movement of the eyes; shivering; general feeling of misery

and weakness, and great depression of spirits, many patients, both men

and women, giving way to weeping; nervous restlessness; inability to

sleep, and occasionally delirium. In some cases catarrhal symptoms

develop, such as running at the eyes, which are sometimes injected on

the second day; sneezing and sore throat; and epistaxis, swelling of

the parotid and submaxillary glands, tonsilitis, and spitting of

bright blood from the pharynx may occur. There is a hard, dry cough of

a paroxysmal kind, worst at night. There is often tenderness of the

spleen, which is almost always found enlarged, and this persists after

the acute symptoms have passed. The temperature is high at the onset

of the disease. In the first twenty-four hours its range is from 100°

F. in mild cases to 105° in severe cases.

Dr J. S. Bristowe gave the following description of the illness during

the same epidemic:--

The chief symptoms of influenza are, coldness along the back, with

shivering, which may continue off and on for two or three days; severe

pain in the head and eyes, often with tenderness in the eyes and pain

in moving them; pains in the ears; pains in the small of the back;

pains in the limbs, for the most part in the fleshy portions, but also

in the bones and joints, and even in the fingers and toes; and febrile

temperature, which may in the early period rise to 104° or 105° F. At

the same time the patient feels excessively ill and prostrate, is apt

to suffer from nausea or sickness and diarrhoea, and is for the most

part restless, though often (and especially in the case of children

and those advanced in age) drowsy.... In ordinary mild cases the above

symptoms are the only important ones which present themselves, and the

patient may recover in the course of three or four days. He may even

have it so mildly that, although feeling very ill, he is able to go

about his ordinary work. In some cases the patients have additionally

some dryness or soreness of the throat, or some stiffness and

discharge from the nose, which may be accompanied by slight bleeding.

And in some cases, for the most part in the course of a few days, and

at a time when the patient seems to be convalescent, he begins to

suffer from wheezing in the chest, cough, and perhaps a little

shortness of breath, and before long spits mucus in which are

contained pellets streaked or tinged with blood.... Another

complication is diarrhoea. Another is a roseolous spotty rash....

Influenza is by no means necessarily attended with the catarrhal

symptoms which the general public have been taught to regard as its

distinctive signs, and in a very large proportion of cases no

catarrhal condition whatever becomes developed at any time.

Several writers have distinguished four main varieties of the

disease--namely, (1) nervous, (2)gastro-intestinal, (3)respiratory, (4)

febrile, a form chiefly found in children. Clifford Allbutt says,

"Influenza simulates other diseases." Many forms are of typhoid or

comatose types. Cardiac attacks are common, not from organic disease but

from the direct poisoning of the heart muscle by influenza.

Perhaps the most marked feature of influenza, and certainly the one

which victims have learned to dread most, is the prolonged debility and

nervous depression that frequently follow an attack. It was remarked by

Nothnagel that "Influenza produces a specific nervous toxin which by its

action on the cortex produces psychoses." In the Paris epidemic of 1890

the suicides increased 25%, a large proportion of the excess being

attributed to nervous prostration caused by the disease. Dr Rawes,

medical superintendent of St Luke's hospital, says that of insanities

traceable to influenza melancholia is twice as frequent as all other

forms of insanity put together. Other common after-effects are

neuralgia, dyspepsia, insomnia, weakness or loss of the special senses,

particularly taste and smell, abdominal pains, sore throat, rheumatism

and muscular weakness. The feature most dangerous to life is the special

liability of patients to inflammation of the lungs. This affection must

be regarded as a complication rather than an integral part of the

illness. The following diagram gives the annual death-rate per million

in England and Wales, and is taken from an article by Dr Arthur

Newsholme in _The Practitioner_ (January 1907).

The deaths directly attributed to influenza are few in proportion to the

number of cases. In the milder forms it offers hardly any danger to life

if reasonable care be taken, but in the severer forms it is a fairly

fatal disease. In eight London hospitals the case-mortality among

in-patients in the 1890 outbreak was 34.5 per 1000; among all patients

treated it was 1.6 per 1000. In the army it was rather less.

The infectious character of influenza having been determined,

suggestions were made for its administrative control on the familiar

lines of notification, isolation and disinfection, but this has not

hitherto been found practicable. In March 1895, however, the Local

Government Board issued a memorandum recommending the adoption of the

following precautions wherever they can be carried out:--

1. The sick should be separated from the healthy. This is especially

important in the case of first attacks in a locality or a household.

2. The sputa of the sick should, especially in the acute stage of the

disease, be received into vessels containing disinfectants. Infected

articles and rooms should be cleansed and disinfected.

3. When influenza threatens, unnecessary assemblages of persons should

be avoided.

4. Buildings and rooms in which many people necessarily congregate

should be efficiently aerated and cleansed during the intervals of

occupation.

There is no routine treatment for influenza except bed. In all cases bed

is advisable, because of the danger of lung complications, and in mild

ones it is sufficient. Severer ones must be treated according to the

symptoms. Quinine has been much used. Modern "anti-pyretic" drugs have

also been extensively employed, and when applied with discretion they

may be useful, but patients are not advised to prescribe them for

themselves.

[Illustration]

Sir Wm. Broadbent in a note on the prophylaxis of influenza recommends

quinine in a dose of two grains every morning, and remarks: "I have had

opportunities of obtaining extraordinary evidence of its protective

power. In a large public school it was ordered to be taken every

morning. Some of the boys in the school were home boarders, and it was

found that while the boarders at the school took the quinine in the

presence of a master every morning, there were scarcely any cases of

influenza among them, although the home boarders suffered nearly as much

as before." He continues, "In a large girls' school near London the same

thing was ordered, and the girls and mistresses took their morning dose

but the servants were forgotten. The result was that scarcely any girl

or mistress suffered while the servants were all down with influenza."

The liability to contract influenza, and the danger of an attack if

contracted, are increased by depressing conditions, such as exposure to

cold and to fatigue, whether mental or physical. Attention should,

therefore, be paid to all measures tending to the maintenance of health.

Persons who are attacked by influenza should at once seek rest, warmth

and medical treatment, and they should bear in mind that the risk of

relapse, with serious complications, constitutes a chief danger of the

disease.

In addition to the ordinary text-books, see the series of articles by

experts on different aspects in _The Practitioner_ (London) for

January 1907.

Encyclopaedia Britannica, 11th Edition, "Indole" to "Insanity" Volume 14, Slice 5 · 第 5 / 10 章