_a. Immediate ignition._
_25 November._ The mixture was applied to a skin area of 6 × 3 cm., and
immediately ignited. After burning 20 seconds it was extinguished with
water, and then wiped off with copper-sulphate solution. During this
operation the entire epidermis separated from the area of the wound. An
oedematous swelling of the surrounding area, 12 × 13 cm. in extent and a
thick scab formed. Treatment took place with _liquid echinacine_. On 7
December the necrosis began to slough off, and gradual epithelization
took place. On 21 December one-third of the area of the wound was still
without epithelium (cf. II/1/a/aa). On 29 December the wound was healed
over.
_25 November._ The mixture was again applied to a skin area of 6 × 3 cm.
and immediately ignited. After it had burned itself out in 60 seconds,
the burned area was wiped off with copper-sulphate solution. A
brownish-grey burn with thickening of the skin appeared. The thickening
developed to a strong scab. It was treated with a 10-percent solution of
cod-liver oil ointment. The surrounding area remained very red and
painful. On 10 December a subcutaneous suppuration appeared at the edge
of the wound. Consequently the treatment with cod-liver oil was replaced
by _liquid echinacine_. On 13 December the scab separated from the
greater part of the wound, but the surrounding area remained more
inflamed than in the corresponding experiment with R 17 (cf. II/1/a/bb).
The granulation was coarse and uneven. On 29 December the wound was not
yet healed over; epithelization advanced only slowly.
_b. Ignition after 30 seconds._
_19 November._ The phosphorus-caoutchouc mixture was applied to 2 sq.
cm. of skin and left there for 30 seconds; then it was ignited and after
burning for 60 seconds wiped off with copper-sulphate solution. A
brownish-black viscous mass formed; the dry wound discolored to a
blackish-grey. Thereupon a thick crust formed and a considerable
oedematous swelling of the area surrounding the wound developed.
Treatment took place with echinacine ointment. The swelling subsided
more slowly than in the treatment with R 17 (cf. II/1/b/aa). On 5
December the wound was without necrosis, with a wide zone of
epithelization. On 29 December it had healed over except for 1 sq. cm.
lacking in epithelium (cf. II/1/bb/aa).
_c. Application to a piece of cloth covering the skin._
_25 November._ The skin was covered with a piece of cloth 6 × 3 cm. to
which the mixture was applied and then ignited. After it had burned
itself out in 57 seconds there remained of the piece of cloth only small
carbonized remnants. After being wiped off with copper-sulphate solution
a yellowish, rather strong thickening of the skin appeared. The wound
was treated with a 10-percent solution of cod-liver oil. A few days
later little blisters appeared, which then dried up on 5 December. On 9
December, thickened, shred-like necroses began to peel off, and a dark
red surface with rough, uneven granulations developed. The
epithelization progressed only slowly. On 29 December the wound was not
yet healed over.