Showing RETENTION, % versus TIME, DAYS for Man, Dog, Rat, Mouse

Figure 22 shows how animals differ in their retention of orally

administered zinc-65, as revealed by a whole body counter. It is

apparent that counters can be used to determine the differences in the

metabolism of different animal species used for research. Standard data

developed in this way can serve to reduce error that may occur if

results from one species are used for interpretation of data for another

species, such as man.

A University of Illinois project to breed meat animals with a high

lean-to-fat ratio has been aided by whole body counters. The tendency to

deposit fat seems to be inherited, and breeding stock with low fat

content can be selected, using “muscle-seeking” potassium-40 to show the

proportion of muscle in each potential parent. The Illinois counter is

unique in being large enough to examine an adult steer (Figure 23). A

similar counter at Cornell University has been used to study animals

infested with internal parasites, comparing them with parasite-free

animals. The counter revealed that a positive relationship exists

between the level of parasite infestation and loss of iron-59-labeled

blood from the digestive tract. The possibility of using this method to

evaluate parasite-killing drugs is being considered. The Cornell counter

is kept clean by covering the animals with plastic sheeting. The same

counter also can serve human patients, who are positioned in a wheeled

hospital stretcher. (See Figure 1D.)

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