1. Merry, disposed to sing. Deep sleep, longer than usual, for the first
three days. Drowsy all day, with frequent yawning, but no desire to
lie down. Insignificant or unpleasant dreams, scarcely recollected on
waking. 5. Sleeps longer, the first day. Headache, on waking. Sleepy with
yawning, after breakfast, the first day. Drowsy after dinner, but no
sleep, second day. Shuddering all over, sweat; the hair stands on end,
second day, 9 in the morning. 10. Heaviness of the head on waking, eight
hours after taking the drug. Weight at the vertex, which seems to press
on the brain, with heaviness of the eyelids and difficulty of opening
them, without sleep. Deep-seated and dull pain in the upper part of the
brain, worse when touched, talking or sitting; less when walking or
moving about, first day. Same symptom on the second day, but less. Sense
of fullness in the head, second day. 15. Sense of fullness in the head,
as if it would split, especially after twelve o’clock, on the third day.
Sensation as if hot water were thrown on the hairy scalp, penetrating
to the brain, second day. The headache disappears on the third day,
it becomes lighter and changes. Sight feebler and dimmer than usual.
Painful heat at the margin of the eyelids, worse when closing the eyes.
20. Dim sight after dinner, second day. Fetid breath. Sensation in the
throat as if one had swallowed some astringent substance. Sensation in
the mouth and throat as if one had eaten some acrid and resinous fruit,
second day, in the morning. Dull pain in the bowels and hypogastrium,
second day. 25. Constipation for three days. Copious urination, in the
morning. Light-colored, watery urine, without smell or sediment, third
day. Violent lancinations cinder the right breast, at each inspiration.
Slight pain at the sternum, when stooping. 30. The voice becomes hoarse
from much coughing. Weariness and numbness of the left arm, with pain in
the humero-cubital articulation, first day. Numbness of the tips of the
fingers, especially the ring-finger. Sensation at the middle of the right
thigh as if bitten by an ant; itching and heat after scratching. Cramp
in the calves during the night, second day.
Second prover: _Mlle. Norma_, 21 years old, sanguine temperament, good
constitution, pale face, melancholy disposition, chestnut-colored hair.
35. Disposed to laugh and jest, first day. Sad, desires to weep; shortly
after, involuntary weeping, sixth day, morning. Long, deep sleep, the
first three days. Sleeps all day, with frequent gaping, but no desire to
lie down. Dreams about quarrelling, she does not recollect her dreams
on waking. 40. First day, sleeps longer than usual in the morning.
Headache on waking. Somnolence after breakfast, with gaping, first day.
Drowsy after dinner, second day. Sad dreams about sick persons in her
family, fifth day. 45. Profuse, cold sweat, and chilliness all over,
with shuddering after the first sleep, sixth day. Shuddering throughout
her body, when lying down. Febrile heat, pale face, cold hands, on the
evening of the sixth day. Two small dark-yellow spots on the neck.
Headache, with a small and feeble pulse; heat in the face, especially
on the right cheek, which is felt very intensely, though the skin feels
cool, first day. 50. Painful stitch in the forehead, worse when opening
the eyes, with external heat of the head on the first day, at 2 in the
afternoon. Stabbing sensation in the right temple, first day, at 3 in the
afternoon. Dull pain, with beating in the left temple, third day. Aching
pain in the temples. Pain in the forehead, with compressive sensation
in the brain, aggravated by walking. 55. Eyes half closed, swollen
externally, surrounded by blue margins, especially near the nose, for
three days. Weight on the eyelids constraining her to close her eyes; in
this state she sees a variety of figures, sixth day. The veins of the
nose are swollen and bluish. Redness and heat of the left ear, for some
minutes, third day. Stomach-ache with sensation of coldness internally.
60. Acute and seated pain in the whole stomach, when rising from a chair,
suffocation, with cold feet, which obliges her to remain in bed, on the
evening of the sixth day. Pains in the muscles of the superior and inner
side of the elbow, like stings of ants. Contusive pain in the arms and
legs. Heaviness and weariness of the limbs, sixth day, morning. 65.
Numbness of the lower limbs, with aversion to exercise. Contusive pain in
the arms and legs, sixth day. Cold feet, in bed, morning.
Third prover: _Mlle. Silvia_, 20 years old, sanguine temperament, good
constitution, gay disposition.
Disposed to sing. Regular and deep sleep, longer than usual, the first
three days. 70. Sleeps all day, with frequent yawning, but no desire
to lie down. Unpleasant dream which she does not recollect on waking.
Wakes at 4 in the morning, falls asleep again a quarter of an hour
afterwards. Light and disturbed sleep, after breakfast, first day, 9 in
the morning. Deep sleep at 10, same day. Deep sleep, second day. 75.
General prostration, with disposition to lie down, but no sleep, third
day, 9 in the morning. Sad dreams, which she does not recollect. No
sleep in bed. Profuse and cold sweat, after her first sleep. Prickings
at the right shoulder, followed by inflammatory redness for 15 minutes.
80. Lancinations or shootings through the whole body, as if needles were
stuck in; followed by itching from the elbow to the hands, with small
violet-colored spots on the arm, back and feet, second day. Pain at
the outer part of the left arm, with a large, red, inflamed spot like
erysipelas. Heat on the surface of the body as from exposure to the sun,
the feet being cold. Pain at the vertex, as from a blow, dull pain on
the top of the head, left side, worse when turning the head or walking,
second day, 11 o’clock in the morning. Benumbing and deep-seated pain
with pressure, in the temples, and dull pain on the vertex, second day.
85. At the moment if lying down in bed, explosion in the head, the noise
passing through the ears, third day. Deep-seated pain, at times in the
forehead, at times in the nape of the neck. Aversion to exercise, she
wants to remain quiet. Laming numbness of the arm and legs, fifth day,
morning. Heaviness in the forehead, when stooping, here and there, sixth
day, noon. 90. Weight in the eyes, and prostration as from sleepiness,
without however being sleepy. Sensitiveness to the light of day. Redness
of the conjunctiva, especially near the internal angle of the left eye.
Sudden inflammation of the left eye at dinner, continuing for three
days. The flame of the candle looks yellow, and seems surrounded by a
red halo. 95. Redness of the wing of the nose and left cheek, third day.
Frequent sneezing after 12, fifth day. Redness on the left cheek. Sharp
lancinations in the epigastrium from within outwards, fifth day, evening.
Lancination in the stomach after dinner, seventh day. 100. Pain in the
throat, with difficulty of swallowing saliva. Catarrh from the third to
the fifth day. When lying down, sensation in the spine as if she had
strained it by lifting a heavy weight, first and second day, evening; the
pain is aggravated by raising herself again or by inclining backwards,
and disappears when she inclines forwards. Numbness at the wrist, along
the course of the cubital nerve, with sensitiveness to contact, second
day, evening. Shooting throughout the body, followed by itching at the
back part of the forearm, second day, morning. 105. Redness and intense
inflammation at the outer part of the left forearm, second day, 11 in
the morning. Burning pain at the left radius, with contusive sensation
when touched, third day. Violent itching of the ball of the left thumb,
followed by inflammatory swelling, third day, evening. Weariness of the
arms and legs, and numbness as after a long walk, fourth day, morning.
Painful numbness at the outer parts of the arms and legs. 110. Cold
feeling in the interior of the bones, fourth day, noon. Numbness of the
anus and legs, with deep-seated pain at times in the forehead, at others
in the nape of the neck, with aversion to motion, fifth day, morning.
Excessive coldness penetrating to the bones, hands and feet, seventh
day. Sudden numbness of the knees, with dull pain in the tibia, first
day, noon. Acute and lancinating pain in the metatarsal bone, which
corresponds to the left little toe. 115. Painful pricking in the left
fifth toe, eighth day, morning, a few moments after, the same toe feels
as if it would turn round from above downwards.
Fourth prover: _Miss Célia_, 17 years old, sanguine temperament, good
constitution, pale face, cheerful disposition, auburn hair.
Evanescent and confused ideas. Want of memory. Passing recollection,
which escape from her mind without her thinking of it. Sadness unto
tears, with headache, second day. 120. Deep sleep, commencing early, and
lasting longer than usual, for three days. Drowsy all day, with frequent
yawning, but no desire to lie down. Unpleasant dreams which she does
not recollect on waking. Quiet sleep in spite of the disturbing dreams
which she forgets on waking, second day. Prostration as from sleepiness,
without desiring to sleep. 125. Dreams about dead bodies, she wakes with
a start and cold sweat all over her body. Sensation as if the finger
were pressed on the right temple, with sensitiveness to contact, second
day, noon. Lancinating pain in the right temple, suddenly shifting to
the left temple and thence to the vertex, where a burning sensation is
experienced, second day. Pain and heat in the forehead, with pressure
on the eyes, second day, three in the afternoon. Dull pain at the root
of the nose, evening. 130. Numbness and compressive sensation as if a
warm bandage were wrapped round the head. General prostration as from
sleepiness. The voice seems to come from afar. The body seems insensible
when she is lying down, and she feels as if in a swoon. When walking she
feels as if she did not touch the soil, and as though she would fall.
135. Painfulness of the eyes, as if the eyeballs were driven out of the
orbits by some foreign body. Sensation as if the head were full of warm
water. Sadness, tears; in her sadness she remains seated, motionless,
speechless (all these symptoms occurred within an hour, second day, after
12). Headache, with weight on the eyes, second day. Sensation as if
stung by ants under the left lower eyelid. 140. Nose slightly inflamed
and shining. Dull pain at the root of the nose, on the evening of the
first day. Pain at the left wing of the nose, which spreads to the
opposite side, followed by bloating on the dorsum of the nose, second
day, at noon. Sense of heat in the face, though the skin feels cool.
Sensation as if a needle had been stuck in the upper lip from within
outwards, eleventh day, on rising in the morning. 145. Toothache. Dry
mouth. Burning tongue as from hot water, on rising from bed. On going to
bed, flow of watery and cold saliva, depositing an ash-colored sediment
and whitish granulations, which taste and smell like bile, but are not
bitter. Sharp and lancinating pain striking through the spleen from below
upwards, second day. 150. Slight colic in the descending colon. From
11 in the morning until evening she urinates every five minutes, with
heat in the urethra, second day. She urinates three or four times an
hour, without pain, third day. Urine colorless, on the following days.
Tightness and beating in the region of the heart, fourth day, evening.
155. Deep-seated and dull pains in the chest, under the sternum. Dull
pain in the posterior cervical region, when moving, the neck, second
day, noon. In the right wrist-joint she feels an internal, sharp pain
which seems to be more violent externally. A similar pain is felt at the
left wrist, but less intense. Pain from the humero-cubital articulation
to the wrist. 160. Numbness at the posterior and internal part of the
forearm. Sharp pain, and sensation of painful roughness at the forearm,
first day, evening. Pain in the right hand, from the circumference to
the centre. Sudden pain at the left little finger, striking through
the whole forearm, becoming seated at the humero-cubital articulation
and increasing gradually, with sensation of constriction, second day,
morning. Shooting, and itching at the internal and upper part of the
forearm, second day, morning. 165. Pains in the last fingers of the
right hand as if they had been struck with a hammer, second day, noon.
Sweat in the palm of the hands, second day, evening. Twisting sensation
in the scapulo-humeral articulation, when stooping, third day. Sense of
paralysis in the forearms and the phalangeal articulations, the fingers
feeling numb, third day, evening. Heat in the skin of the arm, as if
slightly burnt, after rubbing the hand over it. 170. Slight crampy
pain in the tendons of the palms of the hands, and in the forepart
of the wrist. Similar pain in the tendons of the ring-fingers, sixth
day. Renewed crampy pain in the hands, ninth day. Cramp in the right
ring-finger, tenth day. Slight cramps in the hands, twelfth day. 175.
Numbness from the knee to the sole of the foot, where it becomes seated,
first day, noon. Weakness and numbness of the legs, especially when
rising, first day, after 12 in the day-time. Weakness in the legs and
knees when stooping. Weakness in the legs, so that the knees give way,
second day, after 12. Pain at the forepart of the tibia, as from a blow.
180. Contusive pain at the calf, aggravated by contact. Dullness of the
sentient faculty when lying, as if the body were numb.
Fifth prover: _Miss Nina_, 14 years old, sanguine temperament, cheerful
disposition, red face, auburn hair.
The least cause excites her mirth; she would like to sing. Regular sleep,
generally longer than the three first days. Drowsy all day, with frequent
yawning, without any desire to go to bed. Dreams which she is unable to
recollect. Lachrymation, with sensation as of sand in the eyes. Urine
more profuse and of a lighter color. Numbness of the right arm.
Sixth prover: _Mr. Cyprien Huet_, 51 years old, sanguine temperament,
robust constitution, serious disposition, red conjunctiva, weak sight,
redness of the margin of the eyelids.
Very gay. He laughs and sings all day. Deep sleep, commencing sooner and
ending later than usual, for four days. Quarrelsome dreams, second day.
Violet-colored spots elongated horizontally, on the right hypochondrium.
Dull pain at a point on the hairy scalp, and pressure at the occiput
on the right side. 195. Boring pain at the top of the forehead, second
day. Contusive pain at the zygomata. Violent lancinations in the upper
part of the forehead and in the left side of the head, for one minute,
second day, noon. Pain in the upper part of the left parietal bone, as
if the skull would split. Boring pains in the right upper lid, first
day. 200. Dull pain at the right eye, as from a blow, relieved by
pressure, second day, noon. Slight pain in the nose. Intense and sudden
itching on the dorsum of the nose. Stoppage of the right ear, with hard
hearing. Contusive pains in the outer parts of the orbits. 205. Sensation
as of a pustule on the cheek, of the size of a pea, for some seconds.
Violent itching at the same place. Sensation in the throat as from
swallowing some astringent substance. Borborygmi when lying down, second
day, morning. Lancination in the hypochondria. 210. Mucous diarrhœa,
dark-colored, mixed with fæcal matter in hard and single fragments,
third day. Light-colored and copious urine, second and third day. Dry
heat in the palms of the hands, for several days. Sense of contusion in
the muscles of the right forearm, at the inner side between the radius
and cubitus, first day, morning. Crampy pain in the muscles of the right
hand, especially at the thumb, first day, morning. 215. Dull pain and
numbness, as is experienced when pressing the brachial nerve where it
passes over the internal condyle of the humerus; aggravated by contact,
first day, noon. Violent crampy pain in the muscles of the palm of the
right hand, for five minutes. Crampy pain in the left little finger.
Numbness of the fingers of the right hand for several hours, first day,
after 12. Lancination and heat at the tip of the right thumb, as if
there were a whitlow, extending to the first phalangeal articulation.
220. Heaviness and numbness of the extremities, first day, evening.
Contusive pain at the forearm. Itching at the last fingers. Numbness
of the extremities after rising from bed, second day, three different
times. Itching in the palm of the left hand. 225. Pain in the external
middle part of the right forearm, as if needles were thrust in. A similar
feeling at the left arm, but less distinct. On rising from bed, in the
morning, numbness and itching at the right foot, first day. Dull pain in
the knee-joint and bend of the knee, especially the first day. Numbness
and slight itching of the right leg, down to the foot, second day, noon.
230. Slight, acute and circumscribed pains in the groins, repeatedly
and at intervals. Heat in the loins, second day. Dry heat all over,
especially in the palms of the hands. General weakness, every morning
after rising from bed.