The healthy, vigorous pig is practically immune. Experimental
inoculations have uniformly failed to produce the disease. Exception
must be made when inoculation is made into the aqueous humor, in which
there is comparatively little resistance by leucocytes. Sacharoff
succeeded in giving the disease in a fatal form to a young pig in this
way. To weak and debilitated pigs, on the other hand, the disease may be
conveyed as shown by Spinola, and Cadeac and Malet. The symptoms were
engorgement of the tissues in the seat of inoculation with the formation
of glanderous nodules, which undergo molecular degeneration and
ulceration; swelling of the lymph vessels extending from the infected
point, and of the adjacent lymph glands; the formation of glander
nodules in the lungs, liver and spleen, and of nodules and ulcers on the
nasal mucosa.