THE RELATIONS OF ANIMALS TO DISEASE

[Illustration: The life history of the malarial parasite. This cut of the

malarial parasite shows parts of the body of the mosquito and of man. To

understand the life history begin at the point where the mosquito injects

the crescent-shaped bodies into the blood of man. Notice that after the

spores are released from the corpuscles of man two kinds of cells _may be

formed_. These are probably a sexual stage. Development within the body of

the mosquito will only take place when the parasite is taken into its body

at this sexual stage.]

The Cause of Malaria.--The study of the life history and habits of the

Protozoa has resulted in the finding of many parasitic forms, and the

consequent explanation of some kinds of disease. One parasitic protozoan

like an amoeba is called _Plasmodium malariae_. It causes the disease known

as malaria. When a mosquito (the _anopheles_) sucks the blood from a person

having malaria this parasite passes into the stomach of the mosquito. After

completing a part of its life history within the mosquito's body the

parasite establishes itself within the glands which secrete the saliva of

the mosquito. After about eight days, if the infected mosquito bites a

person, some of the parasites are introduced into the blood along with the

saliva. These parasites enter the corpuscles of the blood, increase in

size, and then form spores. The rapid process of spore formation results in

the breaking down of the blood corpuscles and the release of the spores,

and the poisons they manufacture, into the blood. This causes the chill

followed by the fever so characteristic of malaria. The spores may again

enter the blood corpuscles and in forty-eight or seventy-two hours repeat

the process thus described, depending on the kind of malaria they cause.

The only cure for the disease is _quinine_ in rather large doses. This

kills the parasites in the blood. But quinine should not be taken except

under a physician's directions.

[Illustration: How to distinguish the harmless mosquito (_culex_), _a_,

from the malarial mosquito (_anopheles_), _b_, when at rest. Notice the

position of legs and body.]

The Malarial Mosquito.--Fortunately for mankind, not all mosquitoes harbor

the parasite which causes malaria. The harmless mosquito (_culex_) may be

usually distinguished from the mosquito which carries malaria (_anopheles_)

by the position taken when at rest. Culex lays eggs in tiny rafts of one

hundred or more eggs in any standing water; thus the eggs are distinguished

from those of anopheles, which are not in rafts. Rain barrels, gutters, or

old cans may breed in a short time enough mosquitoes to stock a

neighborhood. The larvae are known as wigglers. They breathe through a tube

in the posterior end of the body, and may be recognized by their peculiar

movement when on their way to the surface to breathe. The pupa,

distinguished by a large thoracic region, breathes through a pair of tubes

on the thorax. The fact that both larvae and pupae take air from the surface

of the water makes it possible to kill the mosquito during these stages by

pouring oil on the surface of the water where they breed. The introduction

of minnows, gold fish, or other small fish which feed upon the larvae in the

water where the mosquitoes breed will do much to free a neighborhood from

this pest. Draining swamps or low land which holds water after a rain is

another method of extermination. Some of the mosquito-infested districts

around New York City have been almost freed from mosquitoes by draining the

salt marshes where they breed. Long shallow trenches are so built as to tap

and drain off any standing water in which the eggs might be laid. In this

way the mosquito has been almost exterminated along some parts of our New

England coast.

[Illustration: Swamps are drained and all standing water covered with a

film of oil in order to exterminate mosquitoes. Why is the oil placed on

the surface of the water?]

Since the beginning of historical times, malaria has been prevalent in

regions infested by mosquitoes. The ancient city of Rome was so greatly

troubled by periodic outbreaks of malarial fever that a goddess of fever

came to be worshiped in order to lessen the severity of what the

inhabitants believed to be a divine visitation. At the present time the

malaria of Italy is being successfully fought and conquered by the draining

of the mosquito-breeding marshes. By a little carefully directed oiling of

water a few boys may make an almost uninhabitable region absolutely safe to

live in. Why not try it if there are mosquitoes in your neighborhood?

Yellow Fever and Mosquitoes.--Another disease carried by mosquitoes is

yellow fever. In the year 1878 there were 125,000 cases and 12,000 deaths

in the United States, mostly in Alabama, Louisiana, and Mississippi. During

the French occupation of the Panama Canal zone the work was at a standstill

part of the time because of the ravages of yellow fever. Before the war

with Spain thousands of people were ill in Cuba. But to-day this is

changed, and yellow fever is under almost complete control, both here and

in the Canal zone, where the mosquito (_stegomyia_) which carries yellow

fever exists.

[Illustration: Notice the difference in the number of yearly deaths from

yellow fever before and _after_ the American occupation of Havana.]

This is due to the experiments during the summer of 1900 of a Commission of

United States army officers, headed by Dr. Walter Reed. Of these men one,

Dr. Jesse Lazear, gave up his life to prove experimentally that yellow

fever was caused by mosquitoes. He allowed himself to be bitten by a

mosquito that was known to have bitten a yellow fever patient, contracted

the disease, and died a martyr to science. Others, soldiers, volunteered to

further test by experiment how the disease was spread, so that in the end

Dr. Reed was able to prove to the world that if mosquitoes could be

prevented from biting people who had yellow fever the disease could not be

spread. The accompanying illustration shows the result of this knowledge

for the city of Havana. For years Havana was considered one of the pest

spots of the West Indies. Visitors shunned this port and commerce was much

affected by the constant menace of yellow fever. At the time of the

American occupation after the war with Spain, the experiments referred to

above were undertaken. The city was cleaned up, proper sanitation

introduced, screens placed in most buildings, and the breeding places of

the mosquitoes were so nearly destroyed that the city was practically free

from mosquitoes. The result, so far as yellow fever was concerned, was

startling, as you can see by reference to the chart. Notice also the rise

in the death rate when the young Cuban Republic took control. How do you

account for that? We all know what American scientific medicine and

sanitation is doing in Panama and in the Philippines.

[Illustration: Stegomyia, the carrier of yellow fever. (After Howard.)]

Other Protozoan Diseases.--Many other diseases of man are probably caused

by parasitic protozoans. Dysentery of one kind appears to be caused by the

presence of an amoeba-like animal in the digestive tract which comes

usually through an impure water supply. Smallpox, rabies, and possibly

other diseases are caused by protozoans. Smallpox, which was once the most

dreaded disease known to man, because of its spread in epidemics, has been

conquered by _vaccination_, of which we shall learn more later. The death

rate from rabies or hydrophobia has in a like manner been greatly reduced

by a treatment founded on the same principles as vaccination and invented

by Louis Pasteur.

Another group of protozoan parasites are called _trypanosomes_. These are

parasitic in insects, fish, reptiles, birds, and mammals in various parts

of the world. They cause various diseases of cattle and other domestic

animals, being carried to the animal in most cases by flies. One of this

family is believed to live in the blood of native African zebras and

antelopes; seemingly it does them no harm. But if one of these parasites is

transferred by the dreaded tsetse fly to one of the domesticated horses or

cattle of the colonist of that region, death of the animal results.

Another fly carries a species of trypanosome to the natives of Central

Africa, which causes "the dreaded and incurable sleeping sickness." This

disease carries off more than fifty thousand natives yearly, and many

Europeans have succumbed to it. Its ravages are now largely confined to an

area near the large Central African lakes and the Upper Nile, for the fly

which carries the disease lives near water, seldom going more than 150 feet

from the banks of streams or lakes. The British government is now trying to

control the disease in Uganda by moving all the villages at least two miles

from the lakes and rivers. Among other diseases that may be due to

protozoans is kala-agar, a fever in hot Asiatic countries which is probably

carried by the bedbug, and African tick fever, probably carried by a small

insect called the tick. Bubonic plague, one of the most dreaded of all

infectious diseases, is carried to man by fleas from rats. In this country

many fatal diseases of cattle, as "tick," or Texas cattle fever, are

probably caused by protozoans.

[Illustration: Life history of house flies, showing from left to right the

eggs, larvae, pupae, and adult flies. (Photograph, about natural size, by

Overton.)]

The Fly a Disease Carrier.--We have already seen that mosquitoes of

different species carry malaria and yellow fever. Another rather recent

addition to the black list is the house fly or typhoid fly. We shall see

later with what reason this name is given. The development of the typhoid

fly is extremely rapid. A female may lay from one hundred to two hundred

eggs. These are usually deposited in filth or manure. Dung heaps about

stables, privy vaults, ash heaps, uncared-for garbage cans, and fermenting

vegetable refuse form the best breeding places for flies. In warm weather,

the eggs hatch a day or so after they are laid and become larvae, called

maggots. After about one week of active feeding, these wormlike maggots

become quiet and go into the pupal stage, whence under favorable conditions

they emerge within less than another week as adult flies. The adults breed

at once, and in a short summer there may be over ten generations of flies.

This accounts for the great number. Fortunately relatively few flies

survive the winter. The membranous wings of the adult fly appear to be two

in number, a second pair being reduced to tiny knobbed hairs called

balancers. The head is freely movable, with large compound eyes. The mouth

parts form a proboscis, which is tonguelike, the animal obtaining its food

by lapping and sucking. The foot shows a wonderful adaptation for clinging

to smooth surfaces. Two or three pads, each of which bears tubelike hairs

that secrete a sticky fluid, are found on its under surface. It is by this

means that the fly is able to walk upside down, and carry bacteria on its

feet.

[Illustration: The foot of a fly, showing the hooks, hairs, and pads which

collect and carry bacteria. The fly doesn't wipe his feet.]

[Illustration: Colonies of bacteria which have developed in a culture

medium upon which a fly was allowed to walk.]

The Typhoid Fly a Pest.--The common fly is recognized as a pest the world

over. Flies have long been known to spoil food through their filthy habits,

but it is more recently that the very serious charge of spread of diseases,

caused by bacteria, has been laid at their door. In a recent experiment two

young men from the Connecticut Agricultural Station found that a single fly

might carry on its feet anywhere from 500 to 6,600,000 bacteria, the

average number being over 1,200,000. Not all of these germs are harmful,

but they might easily include those of typhoid fever, tuberculosis, summer

complaint, and possibly other diseases. A recent pamphlet published by the

Merchants' Association in New York City shows that the rapid increase of

flies during the summer months has a definite correlation with the increase

in the number of cases of summer complaint. Observations in other cities

seem to show the increase in number of typhoid cases in the early fall is

due, in part at least, to the same cause. A terrible toll of disease and

death may be laid at the door of the typhoid fly.

[Illustration: Showing how flies may spread disease by means of

contaminating food.]

Recently the stable fly has been found to carry the dread disease known as

infantile paralysis.

[Illustration: There were 329 typhoid cases in Jacksonville, Florida, in

1910, 158 in 1911, 87 in first 10 months of 1912. 80 to 85 per cent of

outdoor toilets were made fly proof during winter of 1910. Account for the

decrease in typhoid after the flies were kept out of the toilets.]

Remedies.--Cleanliness which destroys the breeding place of flies, the

frequent removal and destruction of garbage, rubbish, and manure, covering

of all food when not in use and especially the _careful_ screening of

windows and doors during the breeding season, will all play a part in the

reduction of flies. To the motto "swat the fly" should be added, "remove

their breeding places!"

[Illustration: Flea which transmits Bubonic plague from rat to man.]

Other Insect Disease Carriers.--Fleas and bedbugs have been recently added

to those insects proven to carry disease to man. Bubonic plague, which is

primarily a disease of rats, is undoubtedly transmitted from the infected

rats to man by the fleas. Fleas are also believed to transmit leprosy

although this is not proven.

To rid a house of fleas we must first find their breeding places. Old

carpets, the sleeping places of cats or dogs or any dirty unswept corner

may hold the eggs of the flea. The young breed in cracks and crevices,

feeding upon organic matter there. Eventually they come to live as adults

on their warm-blooded hosts, cats, dogs, or man. Evidently destruction of

the breeding places, careful washing of all infected areas, the use of

benzine or gasoline in crevices where the larvae may be hid are the most

effective methods of extermination. Pets which might harbor fleas should be

washed frequently with a weak (two to three per cent) solution of creolin.

Bedbugs are difficult to prove as an agent in the transmission of disease

but their disgusting habits are sufficient reason for their extermination.

It has been proven by experiment that they may spread typhoid and relapsing

fevers. They prefer human blood to other food and have come to live in

bedrooms and beds because this food can be obtained there. They are

extremely difficult to exterminate because their flat body allows them to

hide in cracks out of sight. Wooden beds are thus better protection for

them than iron or brass beds. Boiling water poured over the cracks when

they breed or a mixture of strong corrosive sublimate four parts, alcohol

four parts and spirits of turpentine one part, are effective remedies.

How the Harm done by Insects is Controlled.--The combating of insects is

directed by several bodies of men, all of which have the same end in view.

These are the Bureau of Entomology of the United States Department of

Agriculture, the various state experiment stations, and medical and civic

organizations.

The Bureau of Entomology works in harmony with the other divisions of the

Department of Agriculture, giving the time of its experts to the problems

of controlling insects which, for good or ill, influence man's welfare in

this country. The destruction of the malarial mosquito and control of the

typhoid fly; the destruction of harmful insects by the introduction of

their natural enemies, plant or animal; the perfecting of the honeybee (see

Hodge, _Nature Study and Life_, page 240), and the introduction of new

species of insects to pollinate flowers not native to this country (see

_Blastophaga_, page 43), are some of the problems to which these men are

now devoting their time.

All the states and territories have, since 1888, established state

experiment stations, which work in cooperation with the government in the

war upon injurious insects. These stations are often connected with

colleges, so that young men who are interested in this kind of natural

science may have opportunity to learn and to help.

The good done by these means directly and indirectly is very great.

Bulletins are published by the various state stations and by the Department

of Agriculture, most of which may be obtained free. The most interesting of

these from the high school standpoint are the Farmers' Bulletins, issued by

the Department of Agriculture, and the Nature Study pamphlets issued by the

Cornell University in New York state.

[Illustration: This diagram shows how bubonic plague is carried to man.

Explain the diagram.]

Animals Other than Insects may be Disease Carriers.--The common brown rat

is an example of a mammal, harmful to civilized man, which has followed in

his footsteps all over the world. Starting from China, it spread to eastern

Europe, thence to western Europe, and in 1775 it had obtained a lodgment in

this country. In seventy-five years it reached the Pacific coast, and is

now fairly common all over the United States, being one of the most

prolific of all mammals. Rats are believed to carry bubonic plague, the

"Black Death" of the Middle Ages, a disease estimated to have killed

25,000,000 people during the fourteenth century. The rat, like man, is

susceptible to plague; fleas bite the rat and then biting man transmit the

disease to him. A determined effort is now being made to exterminate the

rat because of its connection with bubonic plague.

Other Parasitic Animals cause Disease.--Besides parasitic protozoans other

forms of animals have been found that _cause_ disease. Chief among these

are certain round and flat worms, which have come to live as parasites on

man and other animals. A one-sided relationship has thus come into

existence where the worm receives its living from the host, as the animal

is called on which the parasite lives. Consequently the parasite frequently

becomes fastened to its host during adult life and often is reduced to a

mere bag through which the fluid food prepared by its host is absorbed.

Sometimes a complicated life history has arisen from their parasitic

habits. Such is seen in the life history of the liver fluke, a flatworm

which kills sheep, and in the tapeworm.

[Illustration: The life cycle of a tapeworm. (1) The eggs are taken in with

filthy food by the pig; (2) man eats undercooked pork by means of which the

bladder worm (3) is transferred to his own intestine (4).]

Cestodes or Tapeworms.--These parasites infest man and many other

vertebrate animals. The tapeworm (_Taenia solium_) passes through two stages

in its life history, the first within a pig, the second within the

intestine of man. The developing eggs are passed off with wastes from the

intestine of man. The pig, an animal with dirty habits, may take in the

worm embryos with its food. The worm develops within the intestine of the

pig, but soon makes its way into the muscle or other tissues. It is here

known as a bladderworm. If man eats raw or undercooked pork containing

these worms, _he_ may become a host for the tapeworm. Thus during its

complete life history it has two hosts. Another common tapeworm parasitic

on man lives part of its life as an embryo within the muscles of cattle.

The adult worm consists of a round headlike part provided with hooks, by

means of which it fastens itself to the wall of the intestine. This head

now buds off a series of segmentlike structures, which are practically bags

full of sperms and eggs. These structures, called _proglottids_, break off

from time to time, thus allowing the developing eggs to escape. The

proglottids have no separate digestive systems, but the whole body surface,

bathed in digested food, absorbs it and is thus enabled to grow rapidly.

[Illustration: _Trichinella spiralis_ imbedded in human muscle. (After

Leuckart.)]

Roundworms.--Still other wormlike creatures called roundworms are of

importance to man. Some, as the vinegar eel found in vinegar, or the

pinworms parasitic in the lower intestine, particularly of children, do

little or no harm. The pork worm or _trichina_, however, is a parasite

which may cause serious injury. It passes through the first part of its

existence as a parasite in a pig or other vertebrate (cat, rat, or rabbit),

where it lies, covered within a tiny sac or _cyst_, in the muscles of its

hosts. If raw pork containing these worms is eaten by man, the cyst is

dissolved off by the action of the digestive fluids, and the living

trichina becomes free in the intestine of man. Here it reproduces and the

young bore their way through the intestine walls and enter the muscles,

causing inflammation there. This causes a painful and often fatal disease

known as _trichinosis_.

The Hookworm.--The discovery by Dr. C. W. Stiles of the Bureau of Animal

Industry, that the laziness and shiftlessness of the "poor whites" of the

South is partly due to a parasite called the _hookworm_, reads like a fairy

tale.

The people, largely farmers, become infected with a larval stage of the

hookworm, which develops in moist earth. It enters the body usually through

the skin of the feet, for children and adults alike, in certain localities

where the disease is common, go barefoot to a considerable extent.

A complicated journey from the skin to the intestine now follows, the larvae

passing through the veins to the heart, from there to the lungs; here they

bore into the air passages and eventually work their way by way of the

windpipe into the intestine. One result of the injury of the lungs is that

many thus infected are subject to tuberculosis. The adult worms, once in

the food tube, fasten themselves and feed upon the blood of their host by

puncturing the intestine wall. The loss of blood from this cause is not

sufficient to account for the bloodlessness of the person infected, but it

has been discovered that the hookworm pours out a poison into the wound

which prevents the blood from clotting rapidly (see page 315); hence a

considerable loss of blood occurs from the wound after the worm has

finished its meal and gone to another part of the intestine.

[Illustration: A family suffering from hookworm.]

The cure of the disease is very easy; thymol is given, which weakens the

hold of the worm, this being followed by Epsom salts. For years a large

area in the South undoubtedly has been retarded in its development by this

parasite; hundreds of millions of dollars and thousands of lives have been

needlessly sacrificed.

"The hookworm is not a bit spectacular: it doesn't get itself

discussed in legislative halls or furiously debated in political

campaigns. Modest and unassuming, it does not aspire to such dignity.

It is satisfied simply with (1) lowering the working efficiency and

the pleasure of living in something like two hundred thousand persons

in Georgia and all other Southern states in proportion; with (2)

amassing a death rate higher than tuberculosis, pneumonia, or typhoid

fever; with (3) stubbornly and quite effectually retarding the

agricultural and industrial development of the section; with (4)

nullifying the benefit of thousands of dollars spent upon education;

with (5) costing the South, in the course of a few decades, several

hundred millions of dollars. More serious and closer at hand than the

tariff; more costly, threatening, and tangible than the Negro problem;

making the menace of the boll weevil laughable in comparison--it is

preeminently the problem of the South."--_Atlanta Constitution._

Animals that prey upon Man.--The toll of death from animals which prey upon

or harm man directly is relatively small. Snakes in tropical countries kill

many cattle and not a few people.

The bite of the rattlesnake of our own country, although dangerous, seldom

kills. The dreaded cobra of India has a record of over two hundred and

fifty thousand persons killed in the last thirty-five years. The Indian

government yearly pays out large sums for the extermination of venomous

snakes, over two hundred thousand of which have been killed during a single

year.

[Illustration: A flesh-eating reptile, the alligator.]

Alligators and Crocodiles.--These feed on fishes, but often attack large

animals, as horses, cows, and even man. They seek their prey chiefly at

night, and spend the day basking in the sun. The crocodiles of the Ganges

River in India levy a yearly tribute of many hundred lives from the

natives.

Carnivorous animals such as lions and tigers still inflict damage in

certain parts of the world, but as the tide of civilization advances, their

numbers are slowly but surely decreasing so that as important factors in

man's welfare they may be considered almost negligible.

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