"Sir James Macintosh described Mr. Hall, when in his twentieth year,

as attracting notice by a most ingenuous and intelligent countenance,

by the liveliness of his manners, and by such indications of mental

activity as could not be misinterpreted. His appearance was that of

health, yet not of robust health, and he suffered from paroxysms of

pain, during which he would roll about on the carpet in the utmost

agony; but no sooner had the pain subsided than he would resume his

part in conversation with as much cheerfulness and vivacity as before

he had been thus interrupted.

"At that period, though he was strong and active, he often suffered

extremely from the pain to which I have before adverted, and which was

his sad companion through life. On entering his room to commence our

reading, I could at once tell whether or not his night had been

refreshing; for if it had, I found him at the table, the books to be

studied ready, and a vacant chair set for me. If his night had been

restless, and the pain still continued, I found him lying on the sofa,

or more frequently upon three chairs, on which he could obtain an

easier position. At such seasons, scarcely ever did a complaint issue

from his lips; but inviting me to take the sofa, our reading

commenced. They, however, who knew Mr. Hall can conjecture how often,

if he became interested, he would raise himself from the chairs, utter

a few animated expressions, and then resume the favorite reclining

posture. Sometimes, when he was suffering more than usual, he proposed

a walk in the fields, where, with the appropriate book as our

companion, we could pursue the subject. If _he_ was the

preceptor, as was commonly the case in these peripatetic lectures, he

soon lost the sense of pain, and it was difficult to say whether the

body or the mind were brought most upon the stretch in keeping up with

him.

"During the early months of the year 1803, the pain in Mr. Hall's back

increased both in intenseness and continuity, depriving him almost

always of refreshing sleep, and depressing his spirits to an unusual

degree.

"Often has he been known to sit close at his reading, or yet more

intently engaged in abstract thought, for more than twelve hours in

the day; so that when his friends have called upon him, in the hope of

drawing him from his solitude, they have found him in such a state of

nervous excitement as led them to unite their efforts in persuading

him to take some mild narcotic and retire to rest. The painful result

may be anticipated. This noble mind lost its equilibrium.

"Throughout the whole of Mr. Hall's residence at Leicester, he

suffered much from his constitutional complaint; and neither his habit

of smoking nor that of taking laudanum seemed effectually to alleviate

his sufferings. It was truly surprising that this constant, severe

pain, and the means adopted to mitigate it, did not in any measure

diminish his mental energy.

"In 1812 he took from fifty to one hundred drops every night. Before

1826 the quantity had increased to one thousand drops.

"Mr. Hall commonly retired to rest a little before eleven o'clock; but

after his first sleep, which lasted about two hours, he quitted his

bed to obtain an easier position on the floor or upon three chairs,

and would then employ himself in reading the book on which he had been

engaged during the day. Sometimes, indeed often, the laudanum, large

as the doses had become, did not sufficiently neutralize his pain to

remove the necessity for again quitting his bed. For more than twenty

years he had not been able to pass a whole night in bed. When this is

borne in mind it is truly surprising that he wrote and published so

much; nay, that he did not sink into dotage before he was fifty years

of age.

"Early on the Sunday morning (Mr. Addington says) being requested to

see him, I found him in a condition of extreme suffering and

distress. The pain in his back had been uncommonly severe during the

whole night, and compelled him to multiply at very short intervals the

doses of his anodyne, until he had taken no less than 125 grains of

solid opium, equal to more than 3000 drops, or nearly four ounces of

laudanum!! This was the only instance in which I had ever seen him at

all overcome by the soporific quality of the medicine; and it was even

then hard to determine whether the effect was owing so much to the

quantity administered as to the unusual circumstance of its not having

proved, even for a short time, an effectual antagonist to the pain it

was expected to relieve.

"The opium having failed to assuage his pain, he was compelled to

remain in the horizontal posture; but while in this situation a

violent attack in his chest took place, which in its turn rendered an

upright position of the body no less indispensable. The struggle that

ensued between these opposing and alike urgent demands became most

appalling, and it was difficult to imagine that he could survive it,

especially as from the extreme prostration of vital energy, the remedy

by which the latter of these affections had often been mitigated--

viz., bleeding--could not be resorted to. Powerful stimulants, such as

brandy, opium, ether, and ammonia, were the only resources, and in

about an hour from my arrival we had the satisfaction of finding him

greatly relieved."

The following references to the opium habits of Hall are found in

"Gilfillan's Literary Portraits."

"Owing to a pain in his spine, he was obliged to swallow daily great

quantities of ether and laudanum, not to speak of his favorite potion,

tea. This had the effect of keeping him strung up always to the

highest pitch; and, while never intoxicated, he was everlastingly

excited. Had he been a feeble man in body and mind the regimen would

have totally unnerved him. As it was, it added greatly to the natural

brilliance of his conversational powers, although sometimes it appears

to have irritated his temper, and to have provoked ebullitions of

passion, and hasty, unguarded statements.

"A gentleman in Bradford described to us a day he once spent there

with Hall. It was a day of much enjoyment and excitement. At the close

of it Hall felt exceedingly exhausted, and on retiring to rest asked

the landlady for a wine-glass half full of brandy. 'Now,' he says, 'I

am about to take as much laudanum as would kill all this company; for

if I don't, I won't sleep one moment.' He filled the glass with strong

laudanum, went to bed, and enjoyed a refreshing rest."

JOHN RANDOLPH.

The eccentricities of no man in America who has been at all

conspicuous in public life approach the eccentricities of the late

John Randolph of Roanoke. Diseased from his birth, with a temperament

of the most excitable kind, he seems during the greater part of his

days to have lived only just without the bounds of confirmed

insanity. His constitutional infirmities were peculiarly the

infirmities that find relief in opium; and it has generally been

understood that his addiction to the habit was of many years'

continuance and lasted to his death. I have been assured by a Virginia

gentleman that when, in one of his last days, he directed his servant

to write upon a card for his inspection the word "REMORSE," Randolph

was understood to have in mind his excessive use of opium. His

biographer, Mr. Hugh Garland, however, has given apparently as little

prominence to his habit in this respect as was consistent with any

mention of it whatever. The letters which follow contain nearly all

the information that we can gather from this source. Under date of

February, 1817, Randolph says:

"The worst night that I have had since my indisposition commenced. It

was, I believe, a case of _croup_ combined with the affection of

the liver and the lungs. Nor was it unlike tetanus, since the muscles

of the neck and back were rigid, and the jaw locked. I never expected,

when the clock struck two, to hear the bell again. Fortunately, as I

found myself going, I dispatched a servant (about one) to the

apothecary for an ounce of laudanum. Some of this, poured down my

throat, through my teeth, restored me to something like life. I was

quite delirious, but had method in my madness; for they tell me I

ordered Juba to load my gun and to shoot the first 'doctor' that

should enter the room; adding, 'they are only mustard-seed, and will

serve just to sting him.' Last night I was again very sick; but the

anodyne relieved me. I am now persuaded that I might have saved

myself a great deal of suffering by the moderate use of opium."

Under date of March of the same year he writes to a friend: "No

mitigation of my worst symptoms took place until the third day of my

journey, when I threw physic to the dogs, and instead of opium, etc.,

I drank, in defiance of my physician's prescription, copiously of cold

spring water, and ate plentifully of ice. Since that change of regimen

my strength has increased astonishingly, and I have even gained some

flesh, or rather skin."

In a letter to Dr. Brockenbrough, dated May 30, 1828:

"I write again to tell you that extremity of suffering has driven me

to the use of what I have had a horror all my life--I mean opium--and

I have derived more relief from it than I could have anticipated. I

took it to mitigate severe pain, and to check the diarrhea. It has

done both; but to my surprise it has had an equally good effect upon

my cough, which now does not disturb me in the night, and the diarrhea

seldom until toward day-break, and then not over two or three times

before breakfast, instead of two or three-and-thirty times.

His biographer, speaking of the state of his health in the autumn of

1831, says, "Mr. Randolph made no secret of his use of opium at this

time: 'I live by if not upon opium,' said he to a friend. He had been

driven to it as an alleviation of a pain to which few mortals were

doomed. He could not now dispense with its use. 'I am fast sinking,'

said he, 'into an opium-eating sot, but, please God! I will shake off

the incubus yet before I die; for whatever difference of opinion may

exist on the subject of suicide, there can be none as to _rushing

into the presence of our Creator_ in a state of drunkenness,

whether produced by opium or brandy.' To the deleterious influence of

that poisonous drug may be traced many of the aberrations of mind and

of conduct so much regretted by his friends during the ensuing winter

and spring. But he was by no means under its constant influence."

WILLIAM WILBERFORCE.

So little is known, beyond what appears in the following brief

notices, of the opium habits of this distinguished philanthropist,

that their citation here would be of little service to opium-eaters,

except as they tend to show that the regular use of the drug in small

quantities may sometimes be continued for many years without apparent

injury to the health, while the same difficulty in abandoning it is

experienced as attends its disuse by those whose moderation has been

less marked.

The son of Wilberforce, in the "Life" of his distinguished father,

says: "His returning health was in a great measure the effect of a

proper use of opium, a remedy to which even Dr. Pitcairne's judgment

could scarcely make him have recourse; yet it was to this medicine

that he now owed his life, as well as the comparative vigor of his

later years. So sparing was he always in its use, that as a stimulant

he never knew its power, and as a remedy for his specific weakness he

had not to increase its quantity during the last twenty years he

lived. 'If I take,' he would often say,'but a single glass of wine, I

can feel its effect, but I never know when I have taken my dose of

opium by my feelings.' Its intermission was too soon perceived by the

recurrence of disorder."

In a letter from Dr. Gilman, already quoted in the "Reminiscences of

Coleridge," he says, speaking of the difficulty of leaving off opium,

"I had heard of the failure of Mr. Wilberforce's case under an eminent

physician of Bath," etc.

A HALF CENTURY'S USE OF OPIUM.

The case of Wilberforce, however, is thrown into the shade by that of

a gentleman now living in New York, whose use of opium has been much

more protracted than that of the British philanthropist, and who

affirms that opium, instead of weakening his powers of mind or body in

any respect, has, on the contrary, been of eminent service to both.

The compiler would have been glad, in the general interests of

humanity, to omit any reference to this case; but it is a legitimate

part of the story he has undertaken to tell; and however this isolated

exception to the ordinary results of the opium habit may be perverted

as a snare and delusion to others, it can not honestly remain

untold. In the compiler's interview with this gentleman, now in the

one hundred and third year of his age, he was impressed with the

evidences of a physical and mental vigor, and a high moral tone, which

is rarely found in men upon whom rests the weight of even eighty

years. Whatever may be thought of the convictions of the compiler, as

to the enormity of the injury inflicted upon society from the habitual

and increasing use of opium, he can not reconcile it to his sense of

fairness to omit distinct reference to this most anomalous case. The

gentleman in question was born in England in the year 1766, and

received his first commission in the army in 1786. Serving his country

in almost every military station in the world where the martial drum

of England is heard--in India, at the Cape, in the Canadas, on guard

over Napoleon at St. Helena--he illustrates, as almost a solitary

exception, the fact that a use of opium for half a century, varying in

quantity from forty grains daily to many times this amount, does not

_inevitably_ impair bodily health, mental vigor, or the higher

qualities of the moral nature. The use of opium was commenced by this

gentleman in the year 1816, as a relief for a severe attack of

rheumatism, and has been continued to the present time, with the

exception of a very brief period when an eminent physician of Berlin,

at the suggestion of the late Chevalier Bunsen, the Prussian

Embassador to Great Britain, endeavored to break up the habit. In this

effort he was unsuccessful, and the case remains as a striking

illustration of the weakness of that physiological reasoning which

would deduce certain phenomena as the invariable consequences of a

violation of the fundamental laws of health. Until the chemistry of

the living body is better understood, medical science seems obliged to

accept many anomalies which it can not explain. About all that can be

said of such exceptional cases is this: In the great conflagrations

which at times devastate large cities, some huge mass of solid masonry

is occasionally seen in the midst of the wide-spread ruin, looking

down upon prostrate columns, broken capitals, shattered walls, and the

cinders and ashes of a general desolation. The solitary tower

unquestionably stands; but its chief utility lies in this,--that it

serves as a striking monument of the appalling and wide-spread

destruction to which it is the sole and conspicuous exception.

WHAT SHALL THEY DO TO BE SAVED?

Most of the preceding pages were already prepared for the press, when

the attention of the compiler was attracted by a very remarkable

article in _Harper's Magazine_ for August, 1867, entitled, "What

Shall They Do to be Saved?" The graphic vividness of the story, as

well as the profound insight and wide experience with which it was

written, led me to solicit from the unknown author the addition of it

to the pages of my own book. It proved to be from the pen of Fitz Hugh

Ludlow, already recognized by the public as a writer of eminence, both

in science and letters. The permission being freely accorded, I was

still further moved to ask that he would give me a statement of the

method pursued by him in dealing with the class to which it refers.

The letter following his article was his response to my request. It

will be seen to contain an outline of his views upon the subject to

which he has devoted some years of study and practice, and is

especially valuable as embodying the germ of a plan by which,

according to his growing conviction, the opium-eater can alone be

saved. As the conclusions of a writer who seems to the compiler to be

singularly intelligent and definite in his knowledge of this most

interesting and difficult field of disease and treatment, it needs no

further recommendation to the attention of the reader. Since the

publication of his August article, a multitude of letters received

from all portions of the country, asking his advice and assistance in

such cases as this book describes, has left a profound conviction upon

his mind of the most crying need of the establishment of an

institution where opium-eaters can be treated specially. In this view

of the urgent necessities of the case, the compiler most heartily and

earnestly concurs.

* * * * *

I have just returned from forty-eight hours' friendly and professional

attendance at a bedside where I would fain place every young person in

this country for a single hour before the Responsibilities of Life

have become the sentinels and Habit the jailer of his Will.

My patient was a gentleman of forty, who for several years of his

youth occasionally used opium, and for the last eight has habitually

taken it. During these eight years he has made at least three efforts

to leave it off, in each instance diminishing his dose gradually for a

month before its entire abandonment, and in the most successful one

holding the enemy at bay for but a single summer. In two cases he had

no respite of agony from the moment he dropped till he resumed it. In

the third case, a short period of comparative repose succeeded the

first fiery battle, but in the midst of felicitations on his victory

he was attacked by the most agonizing hemicranial headaches (resulting

from what I now fear to have been already permanent disorganization of

the stomach), and went back to his nepenthe in a state of almost

suicidal despair, only after the torture had continued for weeks

without a moment's mitigation.

He had first learned its seductions, as happens with the vast majority

of Anglo-Saxon opium-eaters, through a medical prescription. An attack

of inflamed cornea was treated with caustic applications, and the pain

assuaged by internal doses of M'Munn's Elixir. When my friend came out

of his dark room and bandages at the end of a month he had consumed

twenty ounces of this preparation, whose probable distinction from the

tincture known as laudanum I point out below in the note. [Footnote:

Mr. Frank A. Schlitz has kindly made for me a special analysis of

M'Munn's Elixir, which seems to prove that the process of its

preparation amounts to more than the _denarcotization_ of opium,

which is spoken of on the wrapper of each vial. As nearly as can be

ascertained, M'Munn's Elixir is simply an aqueous infusion of

opium--procured by the ordinary maceration--and preserved from

decomposing by the subsequent addition of a small portion of

alcohol. _Narcotin_ being absolutely insoluble in water is

eliminated as the circular says. This fact alone would not account for

the difference between its action and that of laudanum. This is

explained by the fact that all the other alkaloids possess diverse

rates of solubility in water, and exist in M'Munn's Elixir in very

different relative proportions from those which they bear to each

other in the alcoholic tincture called laudanum.] Here it may not be

superfluous to say that the former preparation has all the essential

properties of the latter, save certain of the constipatory and

stupefying tendencies which, by a private process known to the assigns

of the inventor, have been so masked or removed that it possesses in

many cases an availableness which the practitioner can not despise,

though compelled by the secrecy of its formula to rank it among quack

medicines. The amount of it which my friend had taken during his

month's eclipse represents an ounce of dry gum opium--in rough

measurement a piece as large as a French billiard ball. I thus

particularize because he had never previously been addicted to the

drug; had inherited a sound constitution, and differed from any other

fresh subject only in the intensity of his nervous temperament. I wish

to emphasize the fact that the system of a mere neophyte, with nothing

to neutralize the effects of the drug save the absorbency, so to

speak, of the pain for which it was given, could so rapidly adapt

itself to them as to demand an increase of the dose in such an

alarming ratio. There are certain men to whom opium is as fire to

tow, and my friend was one of these. On the first of October he

sensibly perceived the trifling dose of fifty drops; on the first of

November he was taking, without increased sensation, an ounce vial of

"M'Munn" daily.

From that time--totally ignorant of the terrible trap which lay

grinning under the bait he dabbled with--he continued to take opium at

short intervals for several years. When by the physician's orders he

abandoned "M'Munn," on the subsidence of the eye-difficulty, his

symptoms were uneasy rather than distressing, and disappeared after a

few days' oppression at the pit of the stomach and a few nights'

troubled dreaming. But he had not forgotten the sweet dissolving views

at midnight, the great executive achievements at noonday, the heavenly

sense of a self-reliance which dare go anywhere, say any thing,

attempt any thing in the world. He had not forgotten the nonchalance

under slight, the serenity in pain, the apathy to sorrow, which for

one month set him calm as Boodh in the temple-splendors of his

darkened room. He had not forgotten that the only perfect

_peace_ he had ever experienced was there, and he remembered that

peace as something which seemed to blend all the assuaged passion and

confirmed dignity of old age with that energy of high emprise which

thrills the nerves of manhood. He had tasted as many sources of

earthly pleasure as any man I ever knew; but the ecstasies of form and

color, wine, Eros, music, perfume, all the luxuries of surrounding

which wealth could purchase or high-breeding appreciate, were as

nothing to him in comparison with the memory of that time on which his

family threw away their sympathy when they called it his "month of

_suffering."_

Accordingly, without much more instinct of concealment than if it were

an occasional tendency to some slight convivial excess, he had resort

to M'Munn, in ounce doses, whenever the world went wrong with him. If

he had a headache or a toothache; if the weather depressed him; if he

had a certain "stint" of work to do without the sense of native vigor

to accomplish it; if he was perplexed and wished to clear his head of

passion; if anxieties kept him awake; if irregularities disturbed his

digestion--he had always one refuge certain. No fateful contingency

could pursue him inside M'Munn's enchanted circle. He was a young and

wealthy bachelor, living the life of a refined _bon vivant;_ an

insatiable traveller, surrounded by flatterers, and without a single

friend who loved him enough to warn him of his danger excepting those

who, like himself, were too ignorant to know it. After three years of

dalliance he became an habitual user of opium, and had been one for

eight years when I was first called to him.

By the time that the daily habit fastened itself he had learned of

other opiate preparations than M'Munn's, and finding a certain

insufficiency characterize that tincture as he increased the size of

the dose, had recourse to laudanum, which contains the full native

vigor of the drug unmodified. This nauseated him. He had the same

experience with gum opium, opium pills, and opium powder; so that he

was driven to that form of exhibition which sooner or later naturally

strikes almost every opium-eater as the most portable, energetic, and

instantaneous--morphia or one of its salts. My friend usually kept the

simple alkaloid in a paper, and dissolved it as he needed it in clear

water, sometimes substituting an equivalent of "_Magendie's

Solution_," which contains sixteen grains of the salt diffused

through an ounce of water by the addition of a few drops of sulphuric

acid. When I first saw him he had reached a daily dose of twelve

grains of sulphate of morphia, and on occasions of high excitement had

increased his dose without exaggerating the sensible effect to nearly

twenty. The twelve which formed his habitual _per diem_ were

divided into two equal doses, one taken immediately after rising, the

other just about sundown.

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