Professional men, age of retirement of, 54
longevity of, 50–54
Progeria, 30
Prostate gland, 27
_climacterium virile_ due to changes in, 27
hypertrophy of, 101, 112
age incidence of, 140
cause of, 112
cell changes in, 112, 113
glandular therapy of, 113
vesical disorders due to, 153
senile changes in, 111
Protoplasm, products inimical to vitality of, 65
vital phenomena of, 64, 65, 88
Protozoa, rejuvenation and senescence in, 9–11
Prurigo, senile, 141
Pruritus, senile, 141, 142
Pseudo-paraplegia, 146
Psychical activity, diminished, 119
Psychical fatigue, 122
Puberty, functional activity of cells of testes and ovaries at, 75
period of, 17
“Puberty gland,” 73
Puerilism, 122, 145
Pulmonary changes, 103, 147
Pulmonary tuberculosis, 148
Pulse-pressure, 125
Pulse-rate, 124
Pupils, contraction of, 117
Purgatives, 128
Pyelonephritis, 154
Quinquagenarians, diseases of, 140, 145, 156
Rectum, faecal accumulation in, 152
Reflexes, 119
Regression, 122
Rejuvenescence, 10
associated with reproduction, 9, 10, 64
attainment of old age dependent upon, 9, 10
experimental production of, 76, 77
following vasectomy, 78
gland extracts in production of, 12, 73, 80, 81
in animal life, 9, 10
power of reproduction favouring, 23, 24, 69
restricted diet in relation to, 56
testicular grafts producing, 77
Renal inadequacy, 126
Reproductive power, favouring rejuvenescence, 23, 24, 69
waning of, onset of old age following, 26
prolongation of life after waning of, 23
Retas, Joseph, centenarian, 33
Rheumatism, in old age, 44
Rhizomelic spondylitis, 155
Rhondda, Lord, 49
Richardson, B. W., on the duration of life, 18
Rivers, W. H. R., 122
Roberts, W., 154
Robertson and Ray, 12, 60
Rodent ulcer, 143
Roussy, G., 103, 148
Routh, Martin, centenarian, 50
Roy, D., 32, 95
Russian peasants, longevity of, 40
Salimbeni and Gery, 63, 84, 93, 102
Sand, K., 75
Saundby, R., 8, 44, 85
Savage, G., 34
Sclerosis, arterial, 105–107
Mönckeberg’s, 106, 142
spinal, 97
Scrotum, 114
“Second childhood,” 122, 145
Sedatives, 128
Self-preservation, instinct of, 122
Self-reliance, loss of, 48, 49
Seminal tubules, activity and function of, 74
atrophy of, 74, 112, 113
prostatic enlargement following, 112
regeneration of, 74
Senescence, 136
castration not a disposing factor to, 79
causes of, 62–89
Metchnikoff’s theory, 82, 83
pathological, 82
toxaemic, 82
cell changes during, 62–68
in ovaries and testes, 75, 76
colloidal dehydration leading to, 64, 65
diseases associated with, 139
endocrine glands in relation to, 68–81
healthy and morbid, distinction between, 135
nosological compensations of, 140
progress of, 135
rarity of carcinoma in, 87
rejuvenescence necessary to, 10
thyroid deficiency in relation to, 72
_See also_ Longevity; Old age
Senile climacteric, 30
Senile type of nanism, 31
Senility, 136
_Senium ex morbo_, 136
Sense organs, impairment and failure of, 117–121
Sensibility to pain, blunting of, 117
Septuagenarians, nervous disease among, 145
pathological old age of, 53
Sex characters, secondary, cause of, 75
following castration, 79
Sex glands, changes in, _climacterium virile_ due to, 27
internal secretion of, 70
Sex incidence of old age, 21, 22
Sexagenarians, diseases common to, 140
nervous disease among, 145
Sexual activity, as manifestation of bodily vigour, 69, 70
duration of, 69
leading to rejuvenescence, 69
waning of, 126
Sexual appetite, on what dependent, 75
perverted, 114
Sexual atrophy, as cause of old age and senility, 69–71
Shaking palsy, 144
Sharpey-Schafer, E. A., 63
Sight, impairment of, 117
Sinclair, John, 8, 20, 35
Singer, C., 86
Skeleton, changes in, 98
Skin, 93, 115
diseases of, 141
disposition to, 141
dry, 115
venules and angiomas on, 108
Skull, 100
Sleep, diminished, 119
over-indulgence in, 60
Smell, impairment of sense of, 117
Smith, John, 8, 131
Smith, Lapthorn, 53
Smoking, influence on longevity, 58–59
Sophocles, mental activity at advanced age, 53
Sour milk, destruction of intestinal bacteria by, 83
Spasm of arteriosclerotic vessels, 151
Spastic paraplegia, 147
Spinal cord, degenerative changes in, 97, 147
Spleen, atrophy of, 63, 109
Spondylitis, rhizomelic, 155
Spondylitis deformans, 99, 155
Stapes, fixation of, 118
Starvation, influencing the onset of senescence, 56, 57
Starvation treatment, 56, 57
Steinach, E., 11, 77, 78
Sterne, John, on the attainment of old age, 16
Stevenson, T. H. C., 41
Strachey, L., 47
Structural changes of the body, 90
Symmers, D., 102
Syphilis, influence on longevity, 45
Taste, impairment of, 117
Teeth, decay of, 44, 101
loss of, 44, 45, 99, 101
causes of, 101
Temperance, a characteristic of centenarians, 57
Temperature, and longevity, 26
of body, 116
Testes, atrophy of, 113
cells of, activity and function of, 73, 74
in relation to senescence, 75
changes in, following vasectomy, 77, 78
internal secretion of, 69–72, 74
prostatic atrophy in relation to, 112
Testicular extract, rejuvenescence in relation to, 80
Testicular grafts, rejuvenation by, 71, 72, 77
results of experiments, 76, 79
Thompson, R. J. C., 37, 44, 49, 96, 125
Thompson, W. J., 40
Thrombosis, 144
age incidence of, 145
cerebral, 145
venous, 151
Thymus, atrophy of, 109
Thyroid deficiency, 138
baldness resulting from, 96
effect on activity of body cells, 72
prostatic enlargement in relation to, 113
Thyroid extract, rejuvenescence in relation to, 80
for prostatic enlargement, 113
Thyroid gland, degenerative changes in, 109, 110
Tinnitus, 118
Tissues, connective, relation of cellular activity to, 68, 88, 89, 92
Titian, 53
Tobacco, and arteriosclerosis, 59
influence on longevity, 58
symptoms due to, 59
Todd, R. E., 37, 44, 49, 125
Toxaemia, as a cause of senescence, 82, 86
degenerative changes due to, 44, 55, 56, 86
intestinal, as cause of senescence, 82, 85
over-eating causing, 56
Transfusion, 66
Tremor, senile, 143
Tropical life, influence on longevity, 26, 36, 39
Trousseau, 151
Tuberculosis, senile, 148
Tumours, 86, 141
Turnbull, H. M., 106, 114
Ulcer, rodent, 143
Urea-nitrogen in the blood, 115
Urinary bladder, hypertrophy of, 153
Urine, condition of, 126
Uterine changes, 114
Valvulitis, chronic, 149, 150
Vanity, senile, 120, 121
Variation, correlated, 23
Varicosity, 151
Vascular lesions, 144
Vasectomy, changes due to, 74
changes in testes following, 77, 78
effect on sexual activity, 76
rejuvenescence following, 71, 78
Veins, changes in, 108
Venous thrombosis, 151
Vertebrae, changes in shape of, 99
Vertigo, causes of, 143
Visceral degeneration, 102, 103
Visceroptosis, 102
Vitality, danger of excess of, 54
loss of, 115, 119, 135
waning of, 139
Vitamins, influence on growth, 13
Voltaire, mental activity at advanced age, 53
Voronoff, testicular grafting by, 78
Walker, Kenneth, on changes in the testes, 112
on prostatic enlargement, 112, 113
Walking, functional disturbances in, 147
Waterhouse, B., on the onset of old age, 27
Watson, Thomas, Linacre Lecturer, 5
Weber, Hermann, 8, 34, 43, 57, 119
Weber, Parkes, 35, 104
Weissmann, 9, 16
“Will to live,” 35, 47
Will power, failure of, 122
Williams, Leonard, 61, 113, 128
Wilson, S. A. K., 144
Wounds, healing of, 126
Wrinkles, cause of, 93
Yeo, B., 50
Zorten, Petrasch, centenarian, 20
THE END
_Printed in Great Britain by_ R. & R. CLARK, LIMITED, _Edinburgh_.
By SIR HUMPHRY ROLLESTON, K.C.B., M.D.
DISEASES OF THE LIVER, GALL-BLADDER AND BILE-DUCTS
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Transcriber’s Notes
Punctuation and spelling were made consistent when a predominant
preference was found in this book; otherwise they were not changed.
Simple typographical errors were corrected; occasional unbalanced
quotation marks retained.
Ambiguous hyphens at the ends of lines were retained; occurrences of
inconsistent hyphenation have not been changed.
In Chapter VI, the word “The”, followed by the italicized name of an
organ, sometimes was italicized and sometimes was not. This possible
inconsistency has not been changed here.
Footnotes, originally at the bottoms of pages, have been collected and
placed just before the Index.
Index not checked for proper alphabetization or correct page references.
Page 3: “e sudore britanico” was printed with a macron above the “n”
(n̄).
Fig. 1: “Sir William Beechey” was printed as “Beeching”, but the name
appears correctly in Footnote 5, originally on page 4.