PARKE, DAVIS & COMPANY,

Home Offices and Laboratories.

Detroit, Mich., March 27, 1905.

Mr. Chas. M. Higgins, 271 Ninth St.,

Brooklyn, N. Y.

Dear Sir:

Your communication on the subject of vaccine virus has been

received and contents noted.

What you say about the confusion existing in the minds of the

medical profession as shown by medical text-books regarding

the origin of vaccine is entirely true. No one seems to know

positively the exact nature of this product. It would seem

to us, however, that the theory that cowpox is but modified

smallpox, is the most tenable one. Particularly does this seem

true in view of the facts reported by Dr. Monckton Copeman,

Director of the Government Vaccine work in London, that he had

been able to take smallpox virus, transmit it to monkeys, from

monkeys to heifers, and from heifers to man, the resulting

vaccination on the human subject being identically the same as

that produced by vaccine as ordinarily prepared. Furthermore it

was shown that the persons vaccinated with this vaccine, when

exposed to smallpox, were immune. In other words, the chain of

evidence seems very complete, that by properly transferring

the smallpox virus from man to animals of different species it

became so modified in the transmission that, when applied to

heifers, it produced typical vaccinia, and was found to fill

every requirement as a means of protecting against smallpox

when applied to unimmunized children.

On theoretical grounds it seems to us that this is a very

plausible explanation of the origin of vaccinia. During

Jenner’s time smallpox was very prevalent and nothing could

be more natural than for persons recovering from smallpox

to transmit the disease to the udders of cows, producing an

infection which, on account of the difference in the species of

the animal, modified the smallpox virus.

Regretting that we are unable to state more positively the

exact relation between the two diseases and the origin of the

seed as used by manufacturers, we remain,

Very sincerely yours,

(Signed) PARKE, DAVIS & CO.

THE DISPUTED OR UNKNOWN ORIGIN AND NATURE OF MODERN VACCINE VIRUS

EMPHASIZED. LETTER FROM PARKE, DAVIS & CO., ONE OF THE LARGEST MAKERS

OF VIRUS IN THE U. S.

This letter, like the preceding one, frankly admits the doubt,

ignorance and confusion as to the origin of vaccine virus, and the

practically unknown origin and nature of the seed virus used by

manufacturers, except that it most probably originates in human

smallpox, pure and simple. This letter is given in full on the left and

speaks clearly for itself and is worth reading carefully on this most

important point as it shows the crude, unknown and unscientific basis

of all bovine vaccination which is proved out of the mouths of the

arch-vaccinators themselves. See also page 82.

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