Chlorbutanol, 1,1,1-trichlor-2-methyl-propan-2-ol, CCl_{3}·C (OH)
(CH_{3})·CH_{3} = C_{4}H_{7}OCl_{3}, produced by the reaction of acetone
on chloroform.
Actions and Uses.—It is said to be absorbed unchanged, but to be
decomposed in the body. It is a local anesthetic with an action weaker
than that of cocaine, but sufficient to prevent vomiting from gastric
irritation. Its antiseptic action is said to be fifteen times as strong
as that of boric acid. It acts on the central nervous system similarly
to chloral, and although the claim has been made that hypnotic doses are
without effect on the circulation and respiration, independent observers
have described a fall of blood pressure and interference with
respiration in animals, and consider it fully as dangerous as chloral.
In man 100 grains caused severe symptoms, but recovery occurred. It is
claimed that no habit is induced, but this may be referable to its
restricted employment. It is recommended as a mild local anesthetic, in
dentistry, etc., as a preservative for hypodermic solutions, for
insomnia, vomiting and for spasmodic conditions. It is also said to be
useful as introductory to general anesthesia, lessening excitement and
nausea. Dosage.—The dose is from 0·3 to 1·5 gramme (5 to 20 grains) dry
or in capsules. Hypodermically as a local anesthetic a saturated aqueous
solution may be used.