To Dr. Weir letters patent for the pills were granted by King James II,

1687, with letters of Certification, &c., by King William and Queen

Mary, 1694; and Testification by the Town Council of Edinburgh, 1694.

From Dr. Weir by regular succession and assignation, the secret was

conveyed to his widow, 1711; thence to their son Alex. Weir, 1715;

then to Lilias Weir, his sister, 1726; by her to Dr. Thomas Irving,

her nephew, 1770; then to his widow, Mrs. Irving, 1797; by her to her

son, James Irving, 1814, but the old lady appears to have retained an

interest in them until her death in 1837, at the age of 99. During

her life, and probably before and after, the “shop” where the pills

were made and sold was on the second floor of a house in the Lawn

Market opposite the site of the West Bow, a steep street which led

down to the Grassmarket. The house still remains, the date 1690 being

carved on the lintel. After certain assignations and trusteeships the

property came into the hands of a Mr. J. Rodger who sold his rights to

Messrs. Raimes, Blanshard & Co. in 1876. They and their successors,

Raimes, Clark & Co., Limited, have been the proprietors since the date

mentioned, and they inform me that there is still a small demand for

them.

Formulas for “Anderson’s Scots Pills” will be found in all the

manuals of pharmacy published in Europe and America, but they differ

considerably. Paris in “Pharmacologia” said they were a compound of

aloes and jalap with oil of anise; the French Codex which adopted them,

or at least the name, compounded them of aloes and gamboge with oil

of anise; Niemann, whose formulary had a quasi-official sanction in

Holland early in the nineteenth century gave a much more complicated

recipe, adding to the aloes both jalap and gamboge, together with

sulphur, burnt ivory, liquorice powder, and soap. “Pharmaceutical

Formulas” states that they are well represented by Pil Aloes et Myrrhæ

B.P., “which (saving excipient) contains the same ingredients as those

mentioned in a copy of the original document deposited in the Rolls

House.”

ANODYNE NECKLACES.

Anodyne necklaces were perhaps the most extensively advertised of the

quack remedies of the eighteenth century. The introduction of them is

generally attributed to one of the Chamberlen family, well known in

medical history as the inventors of the modern midwifery forceps.

In a collection of quack advertisements in the British Museum, all

published in the last half of the seventeenth century, there is a

handbill issued by Major John Coke, “a licensed physician and one of

his Majesty’s Chymists” advertising miraculous necklaces for children

breeding teeth “preventing (by God’s assistance) feavers, convulsions,

ruptures, chincough, ricketts, and such attendant distempers.” These

are 5_s._ each. A number of titled people whose children have used

these necklaces are named. A correspondent of _Notes and Queries_

(Mr. J. Elliot Hodgkin, 6th Ser., Vol. IX.) quotes a reference to

anodyne necklaces from a pamphlet published in 1717 dedicated to Dr.

Chamberlen and the Royal Society, evidently an advertisement which

it may not be too uncharitable to suppose was written by Chamberlen

himself. But another correspondent of the same journal (6th Ser., Vol.

X.) quotes from Smith’s “Book for a Rainy Day” another reference to the

necklaces in which they are alluded to as Mr. Burchell’s, and are said

to be “so strongly recommended by two eminent physicians, Dr. Tanner,

the inventor, and Dr. Chamberlain,” to whom he had communicated the

prescription. The necklaces were composed of artificially prepared

beads, small like barleycorns, and they were sold at 5_s._ each.

The beads were often made of peony wood, a substance which Oribasius

(fourth and fifth centuries) recommended to be hung round the neck for

the cure of epilepsy. They were especially recommended for children

cutting teeth, and for pregnant women. No doubt they served like any

other hard substance to help in the former trouble to open the gums,

but the idea suggested was that they gave out a certain vapour or

effluvium which reduced the feverish condition.

“May I die by an anodyne necklace,” is an expression used by one of

the characters in “The Vicar of Wakefield” (Ch. XX.). In a comment on

this allusion by the eminent authority on the eighteenth century, Mr.

Austin Dobson, it was explained that hanging was there euphemistically

referred to. Mr. Dobson’s mistake was pointed out in _Notes and

Queries_, and he acknowledged it.

The Collier de Morand was a neckband sold for goitre. It was made of

carded cotton on which was sprinkled a powder consisting of equal parts

of sal ammoniac, common salt, and burnt sponge. Paracelsus recommended

that coral should be worn round the necks of children to preserve them

from the effects of sorcery.

DAFFY’S ELIXIR.

The Rev. Thomas Daffy, who invented the Elixir Salutis with which his

name has been associated for about 250 years, was rector of Redmile in

Leicestershire from 1660 to 1680. He had been appointed rector of Harby

in the same county in Cromwell’s time, but the Countess of Rutland,

who presumably “sat under” him, was a lady of evangelical ideas, and

the Rev. Thomas was apparently of a “high” tendency, for according

to Nichols’s “History of Leicestershire,” “he was removed from that

better living to this worse one to satisfy the spleen of the Countess

of Rutland, a puritanical lady who had conceived a feeling against

him for being a man of other principles.” Just when he invented his

elixir does not appear, but it is to be hoped that the profits from it

made up for the sacrifice he had to make in consequence of his “other

principles.” It is clear from the references to the medicine which are

found in general literature and from the fact that it was imitated in

the Pharmacopœia (under the formula for Tinctura Sennæ Co.) that it

acquired considerable popularity. The following advertisement from the

_Post Boy_ of January 1, 1707, tells most of what is known about

the elixir:--

Daffye’s famous Elixir Salutis, prepared by Catherine Daffye,

daughter of Mr. Thomas Daffye, late rector of Redmile in the

vale of Belvoir, who imparted it to his kinsman, Mr. Anthony

Daffye, who published the same to the benefit of the community

and to his own advantage. The original receipt is now in my

possession left to me by my father. My own brother, Mr. Daniel

Daffye, apothecary in Nottingham, made this Elixir from the

said receipt and sold it there during his life. Those who know

it will believe what I declare; and those who do not may be

convinced that I am no counterfeit by the colour, taste, smell,

and operation of my Elixir. To be had at the Hand and Pen,

Maiden Lane, Covent Garden.

Catherine Daffy was not a clever advertiser, for her announcement seems

calculated to assist Anthony Daffy’s preparation as much as her own,

and it is likely that this was not her intention. Such little evidence

as exists goes to show that it was Anthony’s and not Catherine’s Elixir

that maintained the fame which had been won.

Daffy’s Elixir is still made by Sutton & Co., of 76 Chiswell Street,

the successors to Dicey & Co., of Bow Church Yard, who were themselves

successors to Benjamin Okell, who was carrying on the business in

1727, but when or from whom, or for what consideration the property

was transferred to them from the Daffy family, is not known. The

old-fashioned handbills wrapped round the bottles state that the

Elixir was “much recommended to the public by Dr. King, Physician to

King Charles II, and the late learned and ingenious Dr. Radcliffe.”

Unhappily, however, “a low set of mercenary vendors” have been making

imitations of this “noble and generous Elixir,” using “foul and

ordinary spirits instead of clean and pure brandy, and base and damaged

drugs,” of which none could be guilty “but such as never feel for any

but themselves.”

BAUME DE FIORAVENTI.

This medicine still figures in the French Codex and in other

continental Pharmacopœias. It is an alcoholic tincture of canella,

cloves, nutmegs, ginger, and other spices, with bay berries, to which

are added amber, galbanum, myrrh, aloes, elemi, and other resins, and

one-sixth by volume of turpentine. After digestion this mixture is

distilled to a yield of about two-thirds of the original bulk. The balm

was formerly given in doses of 5 or 6 drops in kidney disorders, but it

is now only used externally in rheumatism and for chilblains, and for

strengthening the sight. For the last-named purpose the hand is wetted

with the balm and held before the eyes.

Fioraventi was a famous Italian quack in the latter half of the

seventeenth century. He practised in Naples, Rome, Venice, Milan, and

Florence, and was specially honoured in his native city of Bologna,

where he was made a Doctor, a Chevalier, and a Count; titles of which

he made the utmost use. He published numerous works on medicine,

devised various “Nostra,” and pretended to give the exact formulas

for these, but they were always so complicated that no doubt the rich

clients whose patronage Fioraventi cultivated would prefer to buy the

remedies ready compounded. His medical advice though crammed with

bombast was generally sensible, but in all cases he recommended one

or another of “our” remedies. These included “our Balm Artificiall”

(the compound just referred to), “our Electuaria Anglico,” “our Sirrup

Solutivo,” “our Lignum Sanctum,” “our Oleum Benedictum,” and so

forth. Above all Fioraventi made play with his “Petra Philosophale.”

Philosophers had long disputed, he says, whether it was possible to

produce a medicine which would cure all diseases. There was no longer

any occasion for dispute; the discovery of “our Petra Philosophale”

was conclusive. The directions for making this remedy were very

complicated, and of course it was essential that they should be

followed minutely. Briefly, the process was to take so much “Sal Niter,

Roche Allum, and Roman Vitrioll” (I take the names from an old English

translation), “add some Sal Gemmæ, and distil. Then mix Mercury, Sope,

Quick Lime, and Common Ashes, sublime off the Mercury, and add it to

the first distillate. To the mixture add so much steel, iron, and gold,

dry the compound to a stone, which ‘keep as a precious Jewell’ in a

closed glass vessel.”

Why Fioraventi should have troubled to invent any other remedies after

this, or why his patients should have been called upon to buy any

others, is not explained.

BAUME TRANQUILLE

was originally made by the Capucin monk, Aignan, whose religious name

was Father Tranquille. The Capucins of the Louvre were noted in the

seventeenth century for their medical skill, and Father Tranquille was

one of them. Twenty herbs were used in compounding this balsam, among

them poppy, tobacco, lavender, and rue. These were infused in oil. “The

Baume may be made still more effective,” writes Père Rousseau, who was

a fellow monk with Father Tranquille, “by adding as many large live

frogs as there are pounds of oil. These are to be boiled in the oil

until they are almost burnt. Their juice and fat combine with the oil

and greatly augment the excellence of the remedy.” Mme. de Sévigné,

writing to her daughter, December 15, 1684, says, “I am sending you the

most precious treasure I have: my half bottle of Baume Tranquille. I

could not send a full bottle; the Capucins have no more.”

BAUME DE VIE.

Baume de Vie, which is represented by Decoct. Aloes Co., B.P., was

first sold by a French apothecary named Le Lievre, of the Rue de

la Seine, Paris. A second edition of his book recommending it is

dated 1760. He describes himself as “le sieur Lelievre apothicaire,

distillateur du Roi.” He says of it that it gently evacuates the

heterogeneous humours, restores and fortifies the stomach, reanimates

the system without causing any fever or other inconvenience, preserves

the humid radical (a fluid supposed to be the principle of life and

the generator of vigour), makes the blood circulate, absorbs from it

all acids and renders them balsamic, and counteracts debility. He also

advises its use for horses, cattle, and dogs. Le Lievre’s formula, as

given by Cadet de Gassicourt, was as follows:--

Socotrine aloes, treacle, of each 1 oz.; gentian, ½ oz.; rhubarb, 6

drachms; saffron, agaric, zedoary, myrrh, of each 2 drachms; sugar, 4

oz.; proof spirit, 2 lb.

DUTCH DROPS.

Haarlem Oil or Dutch Drops have been made in Haarlem since the year

1672, when they were invented by one Claas Tilly, and they are

still manufactured in Haarlem by a person who claims to be a direct

descendant of the inventor. The preparation is stated in Paris’s

“Pharmacologia” to have as a base the residue left in the still after

the redistillation of turpentine; a red, thick, resinous matter,

sometimes called balsam of turpentine. But the same author adds

that a preparation often sold as Dutch Drops is a mixture of oil of

turpentine, tincture of guaiacum, and spirit of nitre, with oils of

amber and cloves. Dutch Drops are asked for all over the world and

are known to old-fashioned people as “Medicamentum.” In remote places

they are kept in the house and a few drops taken occasionally as a

preventive of disease.

GODFREY’S CORDIAL.

The following advertisement which is taken from Reed’s _Weekly

Journal_, February 22, 1722, throws light on the origin of the still

popular “Godfrey.”

To all retailers and others. The general cordial formerly sold

by Mr. Thomas Godfrey, of Hunsdon, in Hertfordshire, deceas’d,

is now prepar’d according to a receipt written by his own hand,

and by him given to my wife, his relation, is now sold by me

Tho. Humphreys of Ware, in the said county, Surgeon, or at

John Humphreys, at the Head and Sheers in Jewin Street, near

Cripplegate, London. Also may be furnished with Arcanums and

Vomits, and will be allowed the same for selling as formerly.

Godfrey’s Cordial was named in the Medicine Stamp Act of 1812, and was

no doubt a proprietary medicine at that time. It now appears to be made

by anyone who chooses to make it. In Paris’s “Pharmacologia,” (8th

edition, 1833) the following receipt which he says was obtained from a

“wholesale druggist who makes and sells many hundred dozens a year,”

was printed:--

“Infuse 9 oz. of sassafras; 1 oz. each of carraway, coriander, and

anise seeds, in 6 pints of water. Simmer down to 4 pints. When cold add

3 oz. of tincture of opium.”

In 1833 the Philadelphia College of Pharmacy adopted the subjoined

formula for Godfrey’s Cordial in order to ensure uniformity:--

“Tinct. Opii, 1½ pint; molasses, from the sugar refiners, 16 pints;

alcohol, 2 pints; water, 26 pints; carbonate of potash, 2½ oz.; oil of

sassafras, 4 drachms.”

EAU DES CARMES.

Eau de Melisse des Carmes, an aromatic spirit, recommended as a

cordial for internal administration, and to bathe the temples, was

first compounded in the pharmacy of the Barefooted Carmelites, near

the Palace of the Luxembourg in the Faubourg St. Germain in 1611. In

the course of the century the preparation became a valuable property,

and though its composition was kept secret by the monks, formulas

innumerable were published. Richelieu, Elizabeth of Bavaria, mother

of the Regent during Louis XIV’s minority, and later, Voltaire,

“reclaimed” it. Patents authorising the monks to carry on the

manufacture and sale were granted by Louis XIV, Louis XV, and Louis

XVI, but when the last was applied for in 1780, the College of Pharmacy

opposed it, but withdrew their opposition for the consideration of £40

a year which the monks agreed to pay them. In 1791 when the monastic

orders were suppressed and their property confiscated, forty-five

Carmelites of the Monastery of the Vaugirard formed themselves into a

commercial company to manufacture and sell the Eau des Carmes. Their

deed of association provided that the property should remain in the

hands of the forty-five down to the last survivor. This one was a

certain Brother Paradise, who took as a partner a M. Royer and died

in 1831 on the premises in the Rue Taranne where the company had been

constituted. M. Royer died a few years later, and his widow married

a M. Boyer in 1840 who wrote a “Monographie Historique,” which it is

believed was edited for him by Alexander Dumas.

The following formula for a preparation resembling the Eau des Carmes

was published by Baumé after many experiments, and was adopted by the

compilers of the Codex:--

“Balm, in flower, freshly gathered, and freed from the stalks, 2 lbs.;

lemon peel, fresh, 4 oz.; coriander seeds, 8 oz.; nutmegs, cloves,

cinnamon, each bruised, 2 oz.; angelica roots, dried, 1 oz.; spirit of

wine, highly rectified, 10 pints.”

GODDARD’S DROPS.

The original formula for these is given as follows by Dr. William

Salmon in his edition of “Bate’s Dispensatory”:--

R. Humane Bones or rather scales, well dryed, break them into

bits, and put them into a retort, and join thereto a large

Receiver which lute well; and distil first with a gentle Fire,

then with a stronger, increasing the fire gradatim; so will you

have in the Recipient a Flegm, Spirit, Oyl, and Volatile Salt.

Shake the Receiver to loosen the Volatile Salt from the sides,

then close your Receiver and set it in the earth to digest for

three months, after that digest it in a gentle heat fourteen

days, then separate the Oyl which keep for use.

Salmon says they that please may make it according to the prescription,

but he gives an alternative formula which was “to rectify the Oyl from

the Flegm, then to grind the Volatile Salt with the Oyl, and so by a

long digestion to join them together.” Salmon also tells us that if

these drops are distilled from the bones of the skull they are good for

apoplexy, vertigo, megrims, &c., but “if you want it for gout of any

particular limb it is better to make it from the bones of that limb.

The dose is 6 to 12 drops, but it has an evil scent.” You can, however,

correct that, and “Elixirate” the preparation, bringing it “even to a

Fragrancy” if you add so much Spirit of Nitre as will dissolve the oil,

and then mix it with four times its weight of spirit of wine. Then you

should give 20 to 60 drops in a glass of Canary. “So you will have a

medicine beyond all comparison ten times exceeding the other in worth

and efficacy.”

Who was the inventor of this medicine? Salmon says, “The author of

this Recipe was not that Goddard whose Recipes and Prescriptions are

scattered up and down in several places of this book, but the famous

W. Goddard, a great Philosopher and Physician who deserved well of the

World in his Day and Time, and who has even in this Remedy left himself

an Immortal name. And this is the true Medicine which was purchased of

the Doctor by King Charles the Second, so much famed through the whole

kingdom, and for which he gave him, as it is reported, fifteen hundred

pounds sterling.” Other statements say that Charles bought the formula

for £5,000 or £6,000.

Salmon had lived in the reign of Charles II, and may be expected to

have been correct in regard to such a recent event. But in the Roll

of the Royal College of Physicians by William Munk, M.D., published

by the College in 1878 I find the invention of these drops attributed

to Jonathan Goddard, M.D., a person of some historical fame, due

to a large extent to his association with Oliver Cromwell, whom he

accompanied as first physician to his army through his Irish and Scotch

campaigns. Cromwell made him Warden of Merton College, Oxford, and in

other ways showed his confidence in him. In the Little Parliament which

succeeded the Long Parliament Dr. Goddard was the sole representative

of the University of Oxford, and became a member of the Council of

State. With this record it is not surprising that the doctor did not

become a favourite with Charles II. when that monarch returned to

London. Dr. Goddard was removed from his Wardenship, but subsequently

became Professor of Physic at Gresham College, London, and it was

there that he and a few other scientific associates founded the Royal

Society. It is difficult to believe that he was the inventor of the

drops of which Salmon writes; and it is impossible to accept the

statement that he offered, or that the King agreed to purchase, the

secret of their composition from him.

Dr. Munk, however, states that “Dr. Goddard was a good practical

chemist and the inventor of certain volatile drops, the Guttæ

Goddardianæ vel Anglicanæ, as they were termed on the Continent, long

in great repute and commended by Sydenham, who gave them a preference

over all other volatile spirits whatsoever for ‘energetically and

efficaciously attaining the end for which they are applied.’”

There was a Dr. William Goddard admitted a Fellow of the College in

1634 of whom Dr. Munk records that “on the 23rd of November, 1649,

having been contumacious and refusing to attend at his place in the

College, though repeatedly summoned by the President, he was, by a vote

of his colleagues, dismissed from his fellowship: _Decrete Collegii,

in Collegii societale locum amisit._” Dr. Goddard carried the matter

into the Court of King’s Bench, but was defeated.

This was most likely Salmon’s W. Goddard, and seems more like the

genuine Goddard of the Drops fame. Contumaciousness was sometimes a

synonym for exploiting a quack remedy.

In Dr. Martin Lister’s “Journey to Paris,” 1698, that rather garrulous

York doctor states that while he was in Paris (in company with some

members of a diplomatic party) he was sent for by the Prince de Conti

to see his son, and was requested to bring with him some of the late

King Charles’s drops. The doctor replied that he had nothing with him,

and could only prescribe such medicines as would be found in any of

their shops. It was the drops, however, that the Prince wanted and not

the extempore invention of this comparatively unknown practitioner. For

apparently the attendance of Dr. Lister was excused, and he makes the

reflection, after intimating that the young prince died, “It is evident

that there is as false a notion of physic in this country as with

us, and that it is here also thought a knack more than a science or

method; accordingly little toys, the bijoux of quacks are mightily in

request.” Dr. George Henning who edited Dr. Lister’s narrative states

that these drops were made from raw silk which “yields an incredible

quantity of volatile salt and the finest spirit I ever tasted.” He adds

that raw silk is indeed nothing but a dry jelly of the insect kind, and

therefore it must be very cordial and stomachic.

EAU MEDICINALE D’HUSSON.--COLCHICUM.

The medicinal use of colchicum preparations for gout is comparatively

recent and the knowledge of its value for that purpose is undoubtedly

due to its success in a secret proprietary remedy. The authors

of “Pharmacographia” give some interesting historical notes on

_Colchicum autumnale_, L., or meadow saffron, which show how

general was the belief in its deleterious qualities in both classical

and mediæval times. Dioscorides alludes to the poisonous properties of

Kolchikon, which he says grew in Messenia and Kolchis. Pliny and Galen

likewise allude to colchicum as a poison. Pliny recommends milk as an

antidote.

Hermodactylus is recommended for gout in the writings of Alexander of

Tralles, and Paul Egineta (sixth and seventh centuries), and the Arab

doctors, Avicenna, Serapion, and Mesué, describe a similar remedy under

the name of Surengian. It is also recommended by Ambrose Paré, Sylvius

(de la Boe), and other authorities in the sixteenth and seventeenth

centuries; but Tragus (1552) warns his readers against its use for

gout, for which he says it is recommended in Arab writings. Grevin

(1568) observes “ce poison est ennemy de l’homme en tout et par tout.”

Lyte, translating Dodoens (1578), says “Medow or wilde saffron is

corrupt and venomous, therefore not used in medicine.” Gerard declares

the roots of “Mede Saffron” to be “very hurtfull to the stomacke.”

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