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PHYSIOLOGICAL AND PHYSIOLOGICAL CHEMICAL OBSERVATIONS IN EPIDEMIC

INFLUENZA

By C. C. GUTHRIE, PH. D., M. D.

The material consisted of cases in the acute stage of epidemic influenza

with and without clinical pulmonary involvement (alveolar); of

convalescents, and of normal individuals without influenzal history.

It was hoped that it would be possible to follow selected cases over

considerable time periods, observation to compromise coordinated

clinical as well as laboratory data, but the exigencies of the situation

rendered this impossible. Unfortunately, this limits the value of the

studies. But since similar observations were made on cases ranging from

normal to the gravest severity—in fact, preceding death but a few hours

in some instances—and from the nature of the findings, certain

conclusions are clearly warranted.

It is regrettable that the data on certain points is not more extensive,

and particularly that other methods of observation were not employed. As

an example of the latter, measurements and analyses of expired air may

be given, as this was planned from the beginning and unsuccessful

efforts made to provide the required apparatus. In view, however, of the

circumstances of the investigation, it is felt that the studies made

are, on the whole, reasonably comprehensive and complete. And it is only

fair here to acknowledge that this was rendered possible by the cordial

and practical support of the Medical School, the military authorities,

the director of the laboratories, clinical colleagues, particularly Dr.

W. W. G. Maclachlan, and last, but not of less importance, of the

members of the department who made the studies.

In presenting the results, it is deemed most expedient and practical to

omit extensive tabulations and to summarize the data under each subject.

From the report it will be obvious that certain studies were in

preliminary stages at the termination of the investigation. This was due

in certain instances to the lateness of their undertaking, or time

consumed in providing essential equipment and methods; or to

disappearance of suitable cases due to waning of the epidemic.

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