DANGERS OF PYROGALLIC ACID.

By DR. T.L. PHIPSON.

Some time ago, Dr. Napias, of Paris, who devotes much of his time to

matters connected with hygiene, took up the subject of the hygiene of

the photographer, and published in the _Moniteur de la Photographie_ a

series of papers which were afterward translated into English and

published by Messrs. Piper & Carter, of London. In them the worthy

author has considered the action on the economy of the various

poisonous substances which pass daily through the hands of our

readers, and the best means of counteracting their influence.

Since then--in fact, quite recently--attention has been called in the

medical journals to certain properties of pyrogallic acid which were

perfectly unknown, and show that this substance, even when applied

externally, may act as a violent poison causing death by its great

affinity for oxygen. I published a short note upon the subject in the

_Journal of Medicine_, etc., for April last, and it may perhaps be

useful to reproduce the facts here. Physicians who were unacquainted

with this energetic deoxidizing property of pyrogallic acid have

proposed it as a substitute for chrysophanic acid in the treatment of

skin diseases; but Dr. Neisser has made known a case of poisoning by

an ointment of pyrogallic acid, which at once shows that considerable

danger attends its use for this purpose. A man of strong constitution

was admitted into one of the wards of the Breslau Hospital to be

treated for general psoriasis. He appears to have been submitted to a

kind of experimental treatment in order to test the curative

properties of pyrogallic acid as compared with chrysarobine. He was

treated by friction with chrysarobine (in the form of a pomade of

alcoholic extract of rhubarb, containing one-twentieth) on the

one-half of the body, while the other half was treated in the same

manner by a pomade containing ten per cent. of pyrogallic acid. Six

hours after the application the patient had violent shivering with

vomiting and intense collapsus. Death occurred on the fourth day.

Experiments were at once undertaken on rabbits, and proved that this

catastrophe was due entirely to the pyrogallic acid pomade, and that

the chrysarobine was innocuous. In some instances the rabbit died

within two hours. It was also found that in the case of the patient in

the Breslau Hospital the pyrogallic acid had acted by its extreme

avidity for oxygen when in contact with alkaline fluids. The blood had

been affected, and the red corpuscles were destroyed and turned brown.

Very little urine was voided, but it presented a most extraordinary

character, being dark brown and very thick; it contained no blood

corpuscles, but a considerable amount of hæmoglobine (the coloring

matter of the corpuscles), which was recognized by the absorption

bands it gave in the spectroscope. The kidneys were uniformly bluish

black. The blood had a dirty brownish red tint, and contained an

abundance of _detritus_ of red corpuscles.

This case points out once more that photographers cannot use too much

prudence in dealing with chemical products which are in daily use by

them, and the noxious properties of which, they are apt to

forget.--_Photo News._

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A CATALOGUE, containing brief notices of many important

scientific papers heretofore published in the SUPPLEMENT, may

be had gratis at this office.

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THE

SCIENTIFIC AMERICAN SUPPLEMENT.

Scientific American Supplement, No. 312, December 24, 1881 · 第 74 / 76 题