CONTENTS

INTRODUCTION 1

History 1

What Is Radiation? 5

What Is Radioactivity? 5

What Are Radioisotopes? 6

How Are Radioisotopes Used? 7

What Do We Mean by Tracer Atoms? 9

DIAGNOSIS 11

Pinpointing Disease 11

Arsenic-74 14

Chromium-51 15

Cobalt-60 16

Iodine-131 18

Iron-59 23

Phosphorus-32 24

Sodium-24 25

Technetium-99^{_m_} 26

Thulium-170 and Gamma Radiography 27

Tritium 28

Activation Analysis 30

Summary 30

THERAPY 31

A Successful Case 31

General Principles 32

Iodine-131 and Iodine-132 32

Boron-10 33

Phosphorus-32 35

Gold-198 37

Beads, Needles, and Applicators 38

Teletherapy 41

CONCLUSIONS 43

APPENDIX 44

SUGGESTED REFERENCES 47

United States Atomic Energy Commission

Division of Technical Information

Library of Congress Catalog Card Number: 66-62749

1966

[Illustration: THE COVER

This multi-detector positron scanner is used to locate tumors. A

radioisotope-labeled substance is injected into the body and

subsequently concentrates in the tumor tissue. The radioisotope emits

positrons that immediately decay and produce two gamma rays that travel

in opposite directions. These rays are detected simultaneously on a pair

of opposing detection crystals and a line is established along which the

tumor is located. This method is one of many ways doctors use

radioisotopes to combat disease. In this, as in many other procedures

described in this booklet, the patient remains comfortable at all

times.]

[Illustration: THE AUTHOR

Earl W. Phelan is Professor of Chemistry at Tusculum College,

Greeneville, Tennessee. From 1952 to 1965, he served as Staff Assistant

in the Laboratory Director’s Office at Argonne National Laboratory,

where his duties included editing the Argonne Reviews and supplying

information to students. For 22 years prior to moving to Argonne he

served as Head of the Chemistry Department of the Valdosta State College

In Georgia. He received his B.S. and Ph.D. degrees from Cornell

University.]

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