HÆMOPHILIA.

Definition. Causes, lack of plasticity of the blood, thin walls, blood

tension, cardiac erethism, hypertrophy and neurosis. Sex. Heredity

through the female. Treatment, depletive, styptic, astringent.

Transfusion.

This is a constitutional infirmity, usually hereditary and characterized

by the occurrence of profuse and continuous bleeding as the result of

otherwise insignificant injuries or even apart from any recognizable

lesion. It has been attributed to a slow coagulation of the blood, but

at the start of a hæmorrhage the blood is rich in corpuscles and

coagulates firmly. It has also been ascribed to extreme tenuity of the

vascular walls, but this has only been met with in a certain proportion

of the cases. Another potent factor is a permanent over-filling of the

bloodvessels (Immermann, Delafield, Prudden). The same writers attach

importance to cardiac erethism, cardiac hypertrophy, and certain

neurotic influences which temporarily increase the habitually congestive

diathesis. In man the majority of victims have been males, perhaps

because most subject to traumatisms. On the contrary the hereditary

transmission is mainly through the female members of the family. The

families are very prolific, a condition counterbalanced by the death of

the majority of the victims at an early age. Among the lower animals it

has been observed in horses consequent on castration (Siedamgrotzky,

Kohne, Friedberger and Fröhner), setoning (Kohne, Dieckerhoff), and an

ulcer of the leg (Kohne).

_Treatment_ consists in combating plethora and constipation by saline

purgatives. The subject should be carefully protected from injuries.

Locally use styptics such as matico, muriate of iron, tannin, alum with

pressure. Internally ergot, lead acetate, iron chloride, tannin, alum,

or muriate acids. Transfusion is a dernier resort.

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