Two men were inoculated at the same time, the one about 40 years of
age, corpulent, and subject to the rheumatism; the other between 50 and
60, very thin and healthy.
I saw both these patients on the third day, when the places of
insertion were in each so very much inflamed, that I was pretty
certain they would scarce have any eruption, and acquainted them with
my opinion. Both made complaints of itching and uneasiness in the
part; there was however this difference, the elder said he had felt a
numbness and smarting from the time of inoculation, particularly the
following night; that his head had been in pain, and that he had had
several chilly fits: the other complained that his arms felt hot, and
itched, but said he was very well. They both came to me on the sixth
day, when the inflammation on the arm of the elder was considerably
abated; and he said that from the time that I saw him last, he had
remained free from any complaint, except a slight uneasiness at the
parts infected. The incisions of the other were still in an inflamed
state; he said that his head had ached, and that he was very chilly the
preceding night: both these symptoms continued for two days more; but
the attacks were irregular, lasted but a very short time, and there was
not the least appearance of fever. The other held perfectly well, and
all signs of inflammation on the arms of both soon disappeared.
They both remained several days in the same house, and kept company
with others in different stages of the disease; the elder of the two
was inoculated again, but without the least signs of the infection
taking place, and both remain in good health.