The object of this study was to ascertain the effect of repeated dosage
when caffein was given daily or at longer intervals. The experiments
were tried on rabbits and on dogs. As in the experiments on acute
intoxication, the animals were under observation for some time in the
laboratory before the administration of caffein was begun in order to
ascertain the presence or absence of abnormality. The relation of diet
to toxicity received some attention, but the question was not studied
exhaustively in the present investigation.