Three decigrams of caffein per kilo were administered in these
experiments. The results are shown in the following protocols:
_Cat 4. Black and white. Weight, 1,440 grams._
May 26: 10.05 a. m., 22 cc 2 per cent caffein (0.3 gram per kilo)
injected subcutaneously; 11.10 a. m., copious salivation, cat
irritable, muscular stiffness present, but no tetanus; 11.45 a. m., cat
restless, convulsions, attacks of short duration, no paralysis observed
after the convulsions, pupils dilated; 4.45 p. m., cat quiet, slight
paralysis present.
May 27: Cat exhausted.
May 28: Found dead.
_Cat 5. Black and white male. Weight, 1,396 grams._
June 3: 10 a. m. 21 cc of 2 per cent caffein (0.3 gram per kilo)
injected subcutaneously; 12 noon, found dead.
Although there was considerable difference in the duration of life
following the injection of the same dose of caffein per kilo, the final
outcome was the same, as both cats died from the effects of the drug.
One died within 2 hours and the other lived more than 30 hours after
its administration. Three decigrams of caffein per kilo is, therefore,
surely fatal to these animals. Tests made with smaller doses are shown
in the following experiments: