In this series large doses were administered, approximating 0.3 gram
per kilo.
_Rabbit 71. Gray female. Weight, 1,659 grams._
January 20: 2.20 p. m., 25 cc aqueous solution 2 per cent caffein (300
mg per kilo) were injected into the peritoneal cavity; 3.45 p. m., when
doors of cage were opened rabbit had spasm of short duration.
January 21: Rabbit found dead.
_Rabbit 72. Gray and white. Weight, 1,402 grams._
January 21: 11.17 a. m., 20.2 cc (aqueous solution) of 2 per cent
caffein (300 mg per kilo) injected into peritoneal cavity from burette;
11.25 a. m., paralysis; 11.30 a. m., rabbit had convulsion when picked
up from the floor, followed by several spasms later; 11.35 a. m.,
typical tetanus; 12.30 noon, found dead.
_Rabbit 61. Black female. Weight, 2,143 grams._
January 19: 40 cc 2 per cent caffein, aqueous solution (300 mg per
kilo), injected into peritoneal cavity from burette; tetanus when about
30 cc were injected; when removed from holder, repeated and violent
convulsions, terminating in death.