_Washington, D. C., November 14, 1911_.
Sir: I have the honor to submit for your approval a manuscript on the
toxicity of caffein, which is the first of a series of reports to be
made by Dr. Salant on the pharmacology of this drug; the conclusions
here reported are, therefore, in some particulars to be regarded as
tentative. The data obtained are primarily of use in the execution of
the food and drugs act, but are capable of much broader application.
Acknowledgment is made of the assistance rendered by Dr. John R.
Mohler, Chief of the Pathological Division, Bureau of Animal Industry,
and his assistants, in performing the autopsies recorded in this
report. I recommend the publication of the manuscript as Bulletin No.
148 of the Bureau of Chemistry.
Respectfully,
H. W. WILEY, _Chief_.
Hon. JAMES WILSON,
_Secretary of Agriculture_.
This publication may be procured from the Superintendent of Documents,
Government Printing Office Washington, D. C., at 15 cents per copy