DILUENTS:

Watery liquors, which increase the fluidity of the blood, and render

several of the secreted and excreted fluids less viscid.

There are certainly few remedies whose operation is more simple,

obvious, or important; and yet there are scarcely any whose value has

been more mistaken, or whose application has been so frequently

perverted through the suggestions of false theory; water is the

universal beverage of animals, and the necessity of its supply is

indicated by thirst, a sensation which in excess, is borne with less

tranquillity even than that of hunger; in certain morbid states of the

body its presence is to be regarded as indicating the necessity of

copious potation; and yet how often has the prejudiced physician, under

such circumstances, aggravated the pressure of disease, by adding the

sufferings of Tantalus. In febrile affections, the irritation of thirst

tends to keep up the disease, and hence diluents, besides the other

beneficial effects which they may produce, must be regarded as important

remedies. There are also diseases of the alimentary canal which may be

removed by the same agents; when water is conveyed into the intestines

it will have a tendency, by mixing with, and diluting the biliary

secretion, to diminish its acrimony, and thus to obviate a source of

morbid irritation; the dilution of the chyme and chyle may also have a

salutary tendency, and favour the absorption of the finer and more

nutritive parts of the lacteals; and by increasing the fluidity of the

mass, expedite the numerous combinations which it is destined to

undergo. The blood itself is also thus modified in its fluidity;

although it has been very truly observed that in healthy bodies, or such

as are without any obstruction of the excretions, an unusual distension

of the vessels cannot be produced, or at least long subsist; for it is

evident that such an increased quantity of water in the blood will

immediately pass off by one or other of the excretions; this effect,

however, in itself, renders the operation of diluents of signal service

in the treatment of the disease; in consequence, for instance, of their

disposition to pass off by urine, they furnish valuable resources in

diseases of the urinary organs, allaying the pain of strangury, and the

irritation from an inflamed bladder. From these observations, the

practitioner will be led to appreciate the value of diluents; and many

of the beneficial effects which are daily experienced from the copious

potation of mineral waters, are, without doubt, to be wholly attributed

to simple dilution. See _Aqua_.

It is here necessary to say a few words upon the misapplication of this

order of remedies. Dr. Davy found by experiment that when an animal is

bled to death, the last portions of blood that flow are of a much lower

specific gravity than that which flows first, in consequence of the

former containing more water, which it may be inferred was derived by

the increased activity of the absorbents, exerted chiefly on mucous and

serous membranes. Since then venesection promotes and accelerates

absorption,[236] it is clear that, in inflammatory diseases, where we

have recourse to blood-letting, in order to diminish the volume of

circulating fluids, we ought not to suffer the patient to indulge in an

unrestrained use of liquids, which he eagerly demands to satisfy a

thirst which, in all probability, is the natural consequence of

increased absorption. In such cases, it is often better to take liquids

in small divided doses, which will have the effect of moderating the

thirst, without overloading the arterial system, and bringing on that

tension and plenitude which are liable to be produced by swallowing too

large a proportion of liquids.

In the use of water upon such occasions, it may moreover be observed,

that its temperature ought to be attended to; as a general rule it may

be laid down, that in the _cold_ stage it should be hot, in the _hot_,

cold, and in the _sweating_, tepid.

With regard to the value of diluents, as capable of promoting the

operation of other remedies, many observations of great practical

importance might be adduced; but this subject will be more properly

elucidated when we come to consider the influence of solubility in

modifying the activity of medicinal substances, and which constitutes a

very curious and interesting object of chemico-medical enquiry.

While speaking of Diluents it may be cursorily noticed, that water

appears, under certain circumstances of the body, to suffer

decomposition, and to have its elements appropriated to new

combinations. Count Rumford has endeavoured to prove, that the

surprisingly small quantity of solid food which is sufficient for

nourishment, when converted into rich and palatable soup, is owing to

the culinary process having prepared the water for chemical

decomposition,[237] and that this is ultimately effected during the act

of Digestion.[238] It cannot be denied that the exorbitant potation of

water has a tendency to produce fat, but this may depend upon the

vascular distention which is thus occasioned. Gin drinkers, before they

become materially injured by the habit, grow extremely corpulent, as may

often be witnessed in unfortunate cyprians of the lower orders. Can the

hydrogen of the spirit contribute to this effect?

Pharmacologia Fourth American, from the Seventh London Edition · 第 111 / 782 题