ON THE PATHOGENESIS OF COLLIQUATIVE BULLÆ. KREIBICH. (_Derm.
Zeitschr._, Bd. xi, Heft 5, p. 315.)
After reviewing shortly the theories at present put forward for the
production of colliquative bullæ, Kreibich enters into great detail in
the description of his experiments. He finds evidence that in Zoster
hystericus there is an acute œdema consisting of fibrinous exudation
which enters into the cells and causes their necrosis without separating
them from their deep attachments. By irritating the same part three
times running with the poison of urtica urens Kreibich was able to
produce a colliquative vesicle, since the œdematous process then reached
to the papillary body. Similar is the pathogenesis of true herpes zoster
and in all probability of hydroa vacciniforme. To sum up the results of
the investigation he states that “Colliquative bullæ are found in
processes which are allied to urticaria but differ from this in the
greater duration of the vascular lesion and by its situation in the
papillary body. The colliquation of the epithelium is produced by the
action of an exudation rich in fibrin on the epithelial cells, which
have suffered in their nutrition but which have maintained their
connection with the cutis. The disturbance of nutrition is a combined
result of the vascular lesion, the pressure of the exudation, and the
resultant anæmia.”