I may, however, call your attention, briefly, to the singular fact,

that English and American practitioners are apt to accuse French medical

practice of inertness, and French surgical practice of unnecessary

activity. Thus, Dr. Bostock considers French medical treatment, with

certain exceptions, as “decidedly less effective” than that of his own

country. Mr. S. Cooper, again, defends the simple British practice of

procuring union by the first intention against the attacks of M. Roux

and Baron Larrey. [Cooper's Surg. Diet. art. “Wounds.” Yet Mr. John

Bell gives the French surgeons credit for introducing this doctrine of

adhesion, and accuses O'Halloran of “rudeness and ignorance,” and “bold,

uncivil language,” in disputing their teaching. Princ. of Surgery, vol.

i. p. 42. Mr. Hunter succeeded at last in naturalizing the doctrine and

practice, but even he had to struggle against the perpetual jealousy

of rivals, and died at length assassinated by an insult.] We have

often heard similar opinions maintained by our own countrymen. While

Anglo-American criticism blows hot or cold on the two departments of

French practice, it is not, I hope, indecent to question whether all the

wisdom is necessarily with us in both cases.

Our art has had two or three lessons which have a deep meaning to those

who are willing to read them honestly. The use of water-dressings in

surgery completed the series of reforms by which was abolished the

“coarse and cruel practice” of the older surgeons, who with their

dressings and acrid balsams, their tents and leaden tubes, “absolutely

delayed the cure.” The doctrine of Broussais, transient as was its

empire, reversed the practice of half of Christendom for a season, and

taught its hasty disciples to shun their old favorite remedies as mortal

poisons. This was not enough permanently to shift the presumption about

drugs where it belonged, and so at last, just as the sympathetic powder

and the Unguentum Armarium came in a superstitious age to kill out the

abuses of external over-medication, the solemn farce of Homoeopathy was

enacted in the face of our own too credulous civilization, that under

shelter of its pretences the “inward bruises” of over-drugged viscera

might be allowed to heal by the first intention. Its lesson we must

accept, whether we will or not; its follies we are tired of talking

about. The security of the medical profession against this and all

similar fancies is in the average constitution of the human mind with

regard to the laws of evidence.

My friends and brothers in Art! There is nothing to be feared from the

utterance of any seeming heresy to which you may have listened. I cannot

compromise your collective wisdom. If I have strained the truth one

hair's breadth for the sake of an epigram or an antithesis, you are

accustomed to count the normal pulse-beats of sound judgment, and know

full well how to recognize the fever-throbs of conceit and the nervous

palpitations of rhetoric.

The freedom with which each of us speaks his thought in this presence,

belongs in part to the assured position of the Profession in our

Commonwealth, to the attitude of Science, which is always fearless, and

to the genius of the soil on which we stand, from which Nature withheld

the fatal gift of malaria only to fill it with exhalations that breed

the fever of inquiry in our blood and in our brain. But mainly we owe

the large license of speech we enjoy to those influences and privileges

common to us all as self-governing Americans.

This Republic is the chosen home of minorities, of the less power in

the presence of the greater. It is a common error to speak of our

distinction as consisting in the rule of the majority. Majorities, the

greater material powers, have always ruled before. The history of most

countries has been that of majorities, mounted majorities, clad in iron,

armed with death treading down the tenfold more numerous minorities. In

the old civilizations they root themselves like oaks in the soil; men

must live in their shadow or cut them down. With us the majority is only

the flower of the passing noon, and the minority is the bud which may

open in the next morning's sun. We must be tolerant, for the thought

which stammers on a single tongue today may organize itself in the

growing consciousness of the time, and come back to us like the voice of

the multitudinous waves of the ocean on the morrow.

Twenty-five years have passed since one of your honored Presidents spoke

to this Society of certain limitations to the power of our Art, now very

generally conceded. Some were troubled, some were almost angry, thinking

the Profession might suffer from such concessions. It has certainly not

suffered here; if, as some affirm, it has lost respect anywhere, it was

probably for other, and no doubt sufficient reasons.

Since that time the civilization of this planet has changed hands.

Strike out of existence at this moment every person who was breathing on

that day, May 27, 1835, and every institution of society, every art and

every science would remain intact and complete in the living that would

be left. Every idea the world then held has been since dissolved and

recrystallized.

We are repeating the same process. Not to make silver shrines for our

old divinities, even though by this craft we should have our wealth, was

this Society organized and carried on by the good men and true who went

before us. Not for this, but to melt the gold out of the past, though

its dross should fly in dust to all the winds of heaven, to save all our

old treasures of knowledge and mine deeply for new, to cultivate that

mutual respect of which outward courtesy is the sign, to work together,

to feel together, to take counsel together, and to stand together

for the truth, now, always, here, everywhere; for this our fathers

instituted, and we accept, the offices and duties of this time-honored

Society.

BORDER LINES OF KNOWLEDGE IN SOME PROVINCES OF MEDICAL SCIENCE.

An Introductory Lecture delivered before the Medical Class of Harvard

University, November 6, 1861.

[This Lecture appears as it would have been delivered had the time

allowed been less strictly, limited. Passages necessarily omitted

have been restored, and points briefly touched have been more fully

considered. A few notes have been added for the benefit of that limited

class of students who care to track an author through the highways and

by-ways of his reading. I owe my thanks to several of my professional

brethren who have communicated with me on subjects with which they are

familiar; especially to Dr. John Dean, for the opportunity of profiting

by his unpublished labors, and to Dr. Hasket Derby, for information and

references to recent authorities relating to the anatomy and physiology

of the eye.]

The entrance upon a new course of Lectures is always a period of

interest to instructors and pupils. As the birth of a child to a parent,

so is the advent of a new class to a teacher. As the light of the

untried world to the infant, so is the dawning of the light resting

over the unexplored realms of science to the student. In the name of the

Faculty I welcome you, Gentlemen of the Medical Class, new-born babes of

science, or lustier nurslings, to this morning of your medical life, and

to the arms and the bosom of this ancient University. Fourteen years ago

I stood in this place for the first time to address those who occupied

these benches. As I recall these past seasons of our joint labors, I

feel that they have been on the whole prosperous, and not undeserving of

their prosperity.

For it has been my privilege to be associated with a body of true and

faithful workers; I cannot praise them freely to their faces, or I

should be proud to discourse of the harmonious diligence and the noble

spirit in which they have toiled together, not merely to teach their

several branches, but to elevate the whole standard of teaching.

I may speak with less restraint of those gentlemen who have aided me in

the most laborious part of my daily duties, the Demonstrators, to whom

the successive classes have owed so much of their instruction. They rise

before me, the dead and the living, in the midst of the most grateful

recollections. The fair, manly face and stately figure of my friend,

Dr. Samuel Parkman, himself fit for the highest offices of teaching, yet

willing to be my faithful assistant in the time of need, come back to

me with the long sigh of regret for his early loss to our earthly

companionship. Every year I speak the eulogy of Dr. Ainsworth's patient

toil as I show his elaborate preparations: When I take down my “American

Cyclopaedia” and borrow instruction from the learned articles of Dr.

Kneeland, I cease to regret that his indefatigable and intelligent

industry was turned into a broader channel. And what can I say too

cordial of my long associated companion and friend, Dr. Hodges, whose

admirable skill, working through the swiftest and surest fingers that

ever held a scalpel among us, has delighted class after class, and

filled our Museum with monuments which will convey his name to unborn

generations?

This day belongs, however, not to myself and my recollections, but to

all of us who teach and all of you who listen, whether experts in

our specialties or aliens to their mysteries, or timid neophytes just

entering the portals of the hall of science. Look in with me, then,

while I attempt to throw some rays into its interior, which shall

illuminate a few of its pillars and cornices, and show at the same time

how many niches and alcoves remain in darkness.

SCIENCE is the topography of ignorance. From a few elevated points we

triangulate vast spaces, inclosing infinite unknown details. We cast the

lead, and draw up a little sand from abysses we may never reach with our

dredges.

The best part of our knowledge is that which teaches us where knowledge

leaves off and ignorance begins. Nothing more clearly separates a vulgar

from a superior mind, than the confusion in the first between the little

that it truly knows, on the one hand, and what it half knows and what it

thinks it knows on the other.

That which is true of every subject is especially true of the branch of

knowledge which deals with living beings. Their existence is a perpetual

death and reanimation. Their identity is only an idea, for we put off

our bodies many times during our lives, and dress in new suits of bones

and muscles.

“Thou art not thyself;

For thou exist'st on many a thousand grains

That issue out of dust.”

If it is true that we understand ourselves but imperfectly in health,

this truth is more signally manifested in disease, where natural actions

imperfectly understood, disturbed in an obscure way by half-seen causes,

are creeping and winding along in the dark toward their destined issue,

sometimes using our remedies as safe stepping-stones, occasionally, it

may be, stumbling over them as obstacles.

I propose in this lecture to show you some points of contact between our

ignorance and our knowledge in several of the branches upon the study

of which you are entering. I may teach you a very little directly, but I

hope much more from the trains of thought I shall suggest. Do not expect

too much ground to be covered in this rapid survey. Our task is only

that of sending out a few pickets under the starry flag of science to

the edge of that dark domain where the ensigns of the obstinate rebel,

Ignorance, are flying undisputed. We are not making a reconnoissance

in force, still less advancing with the main column. But here are a few

roads along which we have to march together, and we wish to see clearly

how far our lines extend, and where the enemy's outposts begin.

Before touching the branches of knowledge that deal with organization

and vital functions, let us glance at that science which meets you at

the threshold of your study, and prepares you in some measure to deal

with the more complex problems of the living laboratory.

CHEMISTRY includes the art of separating and combining the elements of

matter, and the study of the changes produced by these operations. We

can hardly say too much of what it has contributed to our knowledge of

the universe and our power of dealing with its materials. It has given

us a catalogue raisonne of the substances found upon our planet, and

shown how everything living and dead is put together from them. It is

accomplishing wonders before us every day, such as Arabian story-tellers

used to string together in their fables. It spreads the sensitive film

on the artificial retina which looks upon us through the optician's lens

for a few seconds, and fixes an image that will outlive its original.

It questions the light of the sun, and detects the vaporized metals

floating around the great luminary,--iron, sodium, lithium, and

the rest,--as if the chemist of our remote planet could fill his

bell-glasses from its fiery atmosphere. It lends the power which flashes

our messages in thrills that leave the lazy chariot of day behind them.

It seals up a few dark grains in iron vases, and lo! at the touch of a

single spark, rises in smoke and flame a mighty Afrit with a voice

like thunder and an arm that shatters like an earthquake. The dreams of

Oriental fancy have become the sober facts of our every-day life, and

the chemist is the magician to whom we owe them.

To return to the colder scientific aspect of chemistry. It has shown

us how bodies stand affected to each other through an almost boundless

range of combinations. It has given us a most ingenious theory to

account for certain fixed relations in these combinations. It has

successfully eliminated a great number of proximate compounds, more or

less stable, from organic structures. It has invented others which form

the basis of long series of well-known composite substances. In fact, we

are perhaps becoming overburdened with our list of proximate principles,

demonstrated and hypothetical.

How much nearer have we come to the secret of force than Lully and Geber

and the whole crew of juggling alchemists? We have learned a great deal

about the how, what have we learned about the why?

Why does iron rust, while gold remains untarnished, and gold amalgamate,

while iron refuses the alliance of mercury?

The alchemists called gold Sol, the sun, and iron Mars, and pleased

themselves with fancied relations between these substances and the

heavenly bodies, by which they pretended to explain the facts they

observed. Some of their superstitions have lingered in practical

medicine to the present day, but chemistry has grown wise enough to

confess the fact of absolute ignorance.

What is it that makes common salt crystallize in the form of cubes,

and saltpetre in the shape of six-sided prisms? We see no reason why it

should not have been just the other way, salt in prisms and saltpetre in

cubes, or why either should take an exact geometrical outline, any more

than coagulating albumen.

But although we had given up attempting to explain the essential nature

of affinities and of crystalline types, we might have supposed that we

had at least fixed the identity of the substances with which we deal,

and determined the laws of their combination. All at once we find that a

simple substance changes face, puts off its characteristic qualities and

resumes them at will;--not merely when we liquefy or vaporize a solid,

or reverse the process; but that a solid is literally transformed into

another solid under our own eyes. We thought we knew phosphorus. We warm

a portion of it sealed in an empty tube, for about a week. It has

become a brown infusible substance, which does not shine in the dark

nor oxidate in the air. We heat it to 500 F., and it becomes common

phosphorus again. We transmute sulphur in the same singular way. Nature,

you know, gives us carbon in the shape of coal and in that of the

diamond. It is easy to call these changes by the name allotropism, but

not the less do they confound our hasty generalizations.

These facts of allotropism have some corollaries connected with them

rather startling to us of the nineteenth century. There may be other

transmutations possible besides those of phosphorus and sulphur. When

Dr. Prout, in 1840, talked about azote and carbon being “formed” in the

living system, it was looked upon as one of those freaks of fancy to

which philosophers, like other men, are subject. But when Professor

Faraday, in 1851, says, at a meeting of the British Association, that

“his hopes are in the direction of proving that bodies called simple

were really compounds, and may be formed artificially as soon as we

are masters of the laws influencing their combinations,”--when he comes

forward and says that he has tried experiments at transmutation,

and means, if his life is spared, to try them again,--how can we

be surprised at the popular story of 1861, that Louis Napoleon has

established a gold-factory and is glutting the mints of Europe with

bullion of his own making?

And so with reference to the law of combinations. The old maxim was,

Corpora non agunt nisi soluta. If two substances, a and b, are inclosed

in a glass vessel, c, we do not expect the glass to change them, unless

a or b or the compound a b has the power of dissolving the glass. But

if for a I take oxygen, for b hydrogen, and for c a piece of spongy

platinum, I find the first two combine with the common signs of

combustion and form water, the third in the mean time undergoing no

perceptible change. It has played the part of the unwedded priest, who

marries a pair without taking a fee or having any further relation with

the parties. We call this catalysis, catalytic action, the action of

presence, or by what learned name we choose. Give what name to it we

will, it is a manifestation of power which crosses our established laws

of combination at a very open angle of intersection. I think we may

find an analogy for it in electrical induction, the disturbance of the

equilibrium of the electricity of a body by the approach of a charged

body to it, without interchange of electrical conditions between the

two bodies. But an analogy is not an explanation, and why a few drops

of yeast should change a saccharine mixture to carbonic acid and

alcohol,--a little leaven leavening the whole lump,--not by combining

with it, but by setting a movement at work, we not only cannot explain,

but the fact is such an exception to the recognized laws of combination

that Liebig is unwilling to admit the new force at all to which

Berzelius had given the name so generally accepted.

The phenomena of isomerism, or identity of composition and proportions

of constituents with difference of qualities, and of isomorphism, or

identity of form in crystals which have one element substituted for

another, were equally surprises to science; and although the mechanism

by which they are brought about can be to a certain extent explained

by a reference to the hypothetical atoms of which the elements are

constituted, yet this is only turning the difficulty into a fraction

with an infinitesimal denominator and an infinite numerator.

So far we have studied the working of force and its seeming anomalies

in purely chemical phenomena. But we soon find that chemical force is

developed by various other physical agencies,--by heat, by light, by

electricity, by magnetism, by mechanical agencies; and, vice versa, that

chemical action develops heat, light, electricity, magnetism, mechanical

force, as we see in our matches, galvanic batteries, and explosive

compounds. Proceeding with our experiments, we find that every kind

of force is capable of producing all other kinds, or, in Mr. Faraday's

language, that “the various forms under which the forces of matter are

made manifest have a common origin, or, in other words, are so directly

related and mutually dependent that they are convertible one into

another.”

Out of this doctrine naturally springs that of the conservation of

force, so ably illustrated by Mr. Grove, Dr. Carpenter, and Mr. Faraday.

This idea is no novelty, though it seems so at first sight. It was

maintained and disputed among the giants of philosophy. Des Cartes and

Leibnitz denied that any new motion originated in nature, or that any

ever ceased to exist; all motion being in a circle, passing from one

body to another, one losing what the other gained. Newton, on the

other hand, believed that new motions were generated and existing ones

destroyed. On the first supposition, there is a fixed amount of force

always circulating in the universe. On the second, the total amount may

be increasing or diminishing. You will find in the “Annual of Scientific

Discovery” for 1858 a very interesting lecture by Professor Helmholtz of

Bonn, in which it is maintained that a certain portion of force is lost

in every natural process, being converted into unchangeable heat, so

that the universe will come to a stand-still at last, all force passing

into heat, and all heat into a state of equilibrium.

The doctrines of the convertibility or specific equivalence of the

various forms of force, and of its conservation, which is its logical

consequence, are very generally accepted, as I believe, at the present

time, among physicists. We are naturally led to the question, What is

the nature of force? The three illustrious philosophers just referred

to agree in attributing the general movements of the universe to the

immediate Divine action. The doctrine of “preestablished harmony” was

an especial contrivance of Leibnitz to remove the Creator from unworthy

association with the less divine acts of living beings. Obsolete as this

expression sounds to our ears, the phrase laws of the universe, which

we use so constantly with a wider application, appears to me essentially

identical with it.

Force does not admit of explanation, nor of proper definition, any more

than the hypothetical substratum of matter. If we assume the Infinite as

omnipresent, omniscient, omnipotent, we cannot suppose Him excluded from

any part of His creation, except from rebellious souls which voluntarily

exclude Him by the exercise of their fatal prerogative of free-will.

Force, then, is the act of immanent Divinity. I find no meaning in

mechanical explanations. Newton's hypothesis of an ether filling the

heavenly spaces does not, I confess, help my conceptions. I will, and

the muscles of my vocal organs shape my speech. God wills, and the

universe articulates His power, wisdom, and goodness. That is all I

know. There is no bridge my mind can throw from the “immaterial” cause

to the “material” effect.

The problem of force meets us everywhere, and I prefer to encounter

it in the world of physical phenomena before reaching that of living

actions. It is only the name for the incomprehensible cause of certain

changes known to our consciousness, and assumed to be outside of it. For

me it is the Deity Himself in action.

I can therefore see a large significance in the somewhat bold language

of Burdach: “There is for me but one miracle, that of infinite

existence, and but one mystery, the manner in which the finite proceeds

from the infinite. So soon as we recognize this incomprehensible act as

the general and primordial miracle, of which our reason perceives the

necessity, but the manner of which our intelligence cannot grasp, so

soon as we contemplate the nature known to us by experience in this

light, there is for us no other impenetrable miracle or mystery.”

Medical Essays, 1842-1882 · 第 15 / 31 段