Phenyl-hydrazine is acted upon by aceto-acetic ether, when
phenyl-monomethyl-pyrazolon, ethyl alcohol and water results.
PROPERTIES.--Colorless, odorless, scaly crystals, of a bitterish taste.
Soluble in water, ether and chloroform.
DOSE.--Horses and cattle, 3 to 4 drs.; sheep and pigs, ¹⁄₂ to 1 dr.;
dogs, 5 to 20 grs.
ACTIONS.--Powerful antipyretic, anodyne and local anesthetic,
antiseptic, cardiac depressant; it reduces temperature very quickly,
usually within half an hour and the effects continue two or more hours.
It can be administered by the mouth, hypodermically or intertracheally;
as an antiseptic it diminishes oxidation, and promotes heat loss by
dilating the cutaneous vessels, but more probably by depressing the
activity of the calorifacient centers.
USES.--Used in high fever where the temperature must be reduced quickly,
as in sun-stroke, acute rheumatism; in man a solution of antipyrine from
four to ten per cent strength up, is sprayed into the nostrils for
hay-fever. Acetanilide is a better and safer and much cheaper drug for
febrile diseases.